Back
Anticancer activity of opened arene ruthenium metalla-assemblies.
Journal article

Anticancer activity of opened arene ruthenium metalla-assemblies.

  • 2010-05-06
Published in:
  • Dalton transactions (Cambridge, England : 2003). - 2010
Antineoplastic Agents
Cell Line, Tumor
Coordination Complexes
Humans
Magnetic Resonance Spectroscopy
Mesylates
Molecular Conformation
Porphyrins
Ruthenium
Spectrophotometry, Ultraviolet
English Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)(2)Ru(2)(OO[intersection]OO)(2)](2+) (OO[intersection]OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru(6)(p-cymene)(6)(dobq)(3)(tpp)(2)](6+), with IC(50) values of 2.1 microM and 3.8 microM against A2780 and A2780cisR cells, respectively.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278097
Statistics
Document views: 13 File downloads: