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EEG microstates as biomarker for psychosis in ultra-high-risk patients.

  • de Bock R University Psychiatric Clinics (UPK) Basel, University of Basel, Basel, Switzerland.
  • Mackintosh AJ University Psychiatric Clinics (UPK) Basel, University of Basel, Basel, Switzerland.
  • Maier F University Psychiatric Clinics (UPK) Basel, University of Basel, Basel, Switzerland.
  • Borgwardt S University Psychiatric Clinics (UPK) Basel, University of Basel, Basel, Switzerland.
  • Riecher-Rössler A Faculty of Medicine, University of Basel, Basel, Switzerland.
  • Andreou C Department of Psychology, Division of Clinical Psychology and Epidemiology, University of Basel, Basel, Switzerland. christina.andreou@uksh.de.
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  • 2020-08-26
Published in:
  • Translational psychiatry. - 2020
Biological Psychiatry
Cellular and Molecular Neuroscience
Psychiatry and Mental health
English Resting-state EEG microstates are brief (50-100 ms) periods, in which the spatial configuration of scalp global field power remains quasi-stable before rapidly shifting to another configuration. Changes in microstate parameters have been described in patients with psychotic disorders. These changes have also been observed in individuals with a clinical or genetic high risk, suggesting potential usefulness of EEG microstates as a biomarker for psychotic disorders. The present study aimed to investigate the potential of EEG microstates as biomarkers for psychotic disorders and future transition to psychosis in patients at ultra-high-risk (UHR). We used 19-channel clinical EEG recordings and orthogonal contrasts to compare temporal parameters of four normative microstate classes (A-D) between patients with first-episode psychosis (FEP; n = 29), UHR patients with (UHR-T; n = 20) and without (UHR-NT; n = 34) later transition to psychosis, and healthy controls (HC; n = 25). Microstate A was increased in patients (FEP & UHR-T & UHR-NT) compared to HC, suggesting an unspecific state biomarker of general psychopathology. Microstate B displayed a decrease in FEP compared to both UHR patient groups, and thus may represent a state biomarker specific to psychotic illness progression. Microstate D was significantly decreased in UHR-T compared to UHR-NT, suggesting its potential as a selective biomarker of future transition in UHR patients.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/282730
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