Journal article
Randomized controlled trial of bilateral superficial cervical plexus block versus placebo in thyroid surgery.
- Steffen T Department of Surgery, Kantonsspital St Gallen, St Gallen, Switzerland. Thomas.Steffen@kssg.ch
- Warschkow R
- Brändle M
- Tarantino I
- Clerici T
- 2010-07-16
Published in:
- The British journal of surgery. - 2010
Adolescent
Adult
Aged
Analgesics
Analysis of Variance
Anesthetics, Local
Bupivacaine
Cervical Plexus
Double-Blind Method
Female
Humans
Male
Middle Aged
Nerve Block
Pain Measurement
Pain, Postoperative
Thyroid Diseases
Young Adult
English
BACKGROUND
Bilateral superficial cervical block during thyroid surgery can reduce postoperative pain but its value is unclear. This randomized clinical trial assessed the efficacy of such regional anaesthesia on postoperative pain after thyroid surgery performed under general anaesthesia.
METHODS
Patients undergoing thyroid surgery were randomized to one of four groups in a double-blind fashion. Patients received a cervical block with placebo or bupivacaine at the start or end of surgery. Postoperative pain, analgesic use and length of hospital stay were assessed.
RESULTS
There were 159 patients eligible for analysis. The bupivacaine group had significantly less pain than the placebo group (P = 0.016). The timing of bupivacaine administration did not significantly influence pain (preoperative versus postoperative, P = 0.723). There was no difference between groups in the amount of analgesic used. Length of hospital stay was the same in the bupivacaine and placebo groups (P = 0.925) and when bupivacaine was administered at the beginning or end of surgery (P = 0.087).
CONCLUSION
Bilateral superficial cervical block with bupivacaine combined with general anaesthesia significantly reduced postoperative pain after thyroid surgery.
REGISTRATION NUMBER
NCT00472446 (http://www.clinicaltrials.gov).
Bilateral superficial cervical block during thyroid surgery can reduce postoperative pain but its value is unclear. This randomized clinical trial assessed the efficacy of such regional anaesthesia on postoperative pain after thyroid surgery performed under general anaesthesia.
METHODS
Patients undergoing thyroid surgery were randomized to one of four groups in a double-blind fashion. Patients received a cervical block with placebo or bupivacaine at the start or end of surgery. Postoperative pain, analgesic use and length of hospital stay were assessed.
RESULTS
There were 159 patients eligible for analysis. The bupivacaine group had significantly less pain than the placebo group (P = 0.016). The timing of bupivacaine administration did not significantly influence pain (preoperative versus postoperative, P = 0.723). There was no difference between groups in the amount of analgesic used. Length of hospital stay was the same in the bupivacaine and placebo groups (P = 0.925) and when bupivacaine was administered at the beginning or end of surgery (P = 0.087).
CONCLUSION
Bilateral superficial cervical block with bupivacaine combined with general anaesthesia significantly reduced postoperative pain after thyroid surgery.
REGISTRATION NUMBER
NCT00472446 (http://www.clinicaltrials.gov).
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/bjs.7077
- PMID 20632263
- Persistent URL
- https://sonar.ch/global/documents/291061
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