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Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure.
Journal article

Anakinra is a possible alternative in the treatment and prevention of acute attacks of pseudogout in end-stage renal failure.

  • Announ N Division of Rheumatology, Department of Internal Medicine, University Hospitals of Geneva and University of Geneva School of Medicine, Geneva, Switzerland.
  • Palmer G
  • Guerne PA
  • Gabay C
  • 2009-03-18
Published in:
  • Joint bone spine. - 2009
Aged
Anti-Inflammatory Agents, Non-Steroidal
Antirheumatic Agents
Chondrocalcinosis
Contraindications
Humans
Interleukin 1 Receptor Antagonist Protein
Interleukin-1
Kidney Failure, Chronic
Male
Treatment Outcome
English We describe the case of a 71-year-old man with recurrent pseudogout attacks affecting multiple joints. He had end-stage renal failure that contra-indicated the use of non-steroidal anti-inflammatory drugs and was resistant to therapy with glucocorticoids. Based on the recent findings that interleukin (IL)-1beta is involved in crystal-induced inflammation, the patient received anakinra, a specific IL-1 inhibitor, in order to treat an acute attack of pseudogout. In addition, anakinra was administered as preventive therapy 3days per week after each hemodialysis session. Under this treatment, he did not present any severe episode of arthritis after a follow-up of 8 months. This observation suggests that anakinra is efficacious and safe for the prevention of crystal-induced arthritis in patients with severe renal failure.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/46446
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