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Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury.
Journal article

Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury.

  • van de Looij Y Division of Child Development & Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland; Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. Electronic address: yohan.vandelooij@epfl.ch.
  • Dean JM Department of Physiology, University of Auckland, Auckland, New Zealand.
  • Gunn AJ Department of Physiology, University of Auckland, Auckland, New Zealand.
  • Hüppi PS Division of Child Development & Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland.
  • Sizonenko SV Division of Child Development & Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland.
  • 2015-03-31
Published in:
  • International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. - 2015
Advanced magnetic resonance imaging
Advanced magnetic resonance spectroscopy
Animal models of perinatal brain injury
Diffusion imaging
Manganese enhanced magnetic resonance imaging
Phase and susceptibility imaging
Animals
Animals, Newborn
Brain
Brain Injuries
Disease Models, Animal
Humans
Image Enhancement
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Molecular Imaging
Nerve Fibers, Myelinated
English Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are widely used in the field of brain development and perinatal brain injury. Due to technical progress the magnetic field strength (B0) of MR systems has continuously increased, favoring (1)H-MRS with quantification of up to 18 metabolites in the brain and short echo time (TE) MRI sequences including phase and susceptibility imaging. For longer TE techniques including diffusion imaging modalities, the benefits of higher B0 have not been clearly established. Nevertheless, progress has also been made in new advanced diffusion models that have been developed to enhance the accuracy and specificity of the derived diffusion parameters. In this review, we will describe the latest developments in MRS and MRI techniques, including high-field (1)H-MRS, phase and susceptibility imaging, and diffusion imaging, and discuss their application in the study of cerebral development and perinatal brain injury.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/46790
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