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Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease.

  • Nato G Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
  • Caramello A Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
  • Trova S Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
  • Avataneo V Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy.
  • Rolando C Departement of Biomedecin, University of Basel, Basel 4050, Switzerland.
  • Taylor V Departement of Biomedecin, University of Basel, Basel 4050, Switzerland.
  • Buffo A Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy Department of Neuroscience Rita Levi-Montalcini, University of Turin, Turin 10126, Italy.
  • Peretto P Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy paolo.peretto@unito.it federico.luzzati@unito.it.
  • Luzzati F Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano 10043, Italy paolo.peretto@unito.it federico.luzzati@unito.it.
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  • 2015-02-07
Published in:
  • Development (Cambridge, England). - 2015
Huntington's disease
Lesion-induced neurogenesis
Mouse
Neural stem cells
Parenchymal progenitors
Stem cell quiescence
Animals
Astrocytes
Fluorescent Antibody Technique
Huntington Disease
Ki-67 Antigen
Mice
Mice, Inbred C57BL
Microtubule-Associated Proteins
Neural Stem Cells
Neurogenesis
Neuropeptides
English In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/53500
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