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Biomarker development for presymptomatic molecular diagnosis of preeclampsia: feasible, useful or even unnecessary?

  • Hahn S Laboratory for Prenatal Medicine, Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, CH 4031 Basel, Switzerland.
  • Lapaire O
  • Than NG
  • 2015-03-17
Published in:
  • Expert review of molecular diagnostics. - 2015
animal model
early-onset/late-onset
etiology
placenta
preeclampsia
screening
Animals
Asymptomatic Diseases
Biomarkers
Female
Galectins
Humans
Immunity, Innate
Incidence
Placenta
Pre-Eclampsia
Pregnancy
Pregnancy Proteins
Time Factors
English The past decade saw the advent of a number of promising biomarkers to detect pregnancies at risk for preeclampsia (PE), the foremost being those associated with an imbalance of angiogenic factors. In late pregnancy, these are useful for the detection of imminent cases of PE, while earlier they were more predictive for early- than late-onset PE. This suggests that there may be fundamental differences between the underlying pathology of these two PE forms. Therefore, it is possible that such a biological premise may limit the development of biomarkers that will permit the efficacious detection of both early- and late-onset PE via an analysis of first-trimester maternal blood samples. Consequently, a significant increase in our understanding of the underlying pathology of PE, using a variety of approaches ranging from systems biology to animal models, will be necessary in order to overcome this obstacle.
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  • English
Open access status
hybrid
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Persistent URL
https://sonar.ch/global/documents/53522
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