Journal article
Intragastric pH during treatment with omeprazole: role of Helicobacter pylori and H. pylori-associated gastritis.
- Verdú EF Division of Gastroenterology, CHUV, Lausanne, Switzerland.
- Armstrong D
- Idström JP
- Labenz J
- Stolte M
- Börsch G
- Blum AL
- 1996-12-01
Published in:
- Scandinavian journal of gastroenterology. - 1996
Adult
Anti-Ulcer Agents
Female
Gastric Mucosa
Gastrins
Gastritis
Gastroscopy
Helicobacter Infections
Helicobacter pylori
Humans
Hydrogen-Ion Concentration
Male
Omeprazole
Radioimmunoassay
English
BACKGROUND
Omeprazole treatment produces lower intragastric pH values 4 weeks after cure of Helicobacter pylori infection than before. We therefore investigated the effect of healing H. pylori-associated gastritis on intragastric pH in the presence and in the absence of omeprazole therapy.
METHODS
Before and on day 8 of omeprazole, 20 mg once daily, 24-h intragastric pH-recordings were performed in 14 subjects with H. pylori infection and repeated 4 and 52 weeks after cure of infection. Gastritis severity in corpus and antrum was graded by using a modified Sydney system.
RESULTS
In the absence of omeprazole administration, median 24-h pH values before cure did not differ from those 4 and 52 weeks after cure. On day 8 of omeprazole administration, 24-h pH values were much higher before cure (median, 5.15; 95% confidence interval (CI), 4.3-6.0) than 4 weeks (3.6; 2.1-4.4; P < 0.001) and 52 weeks after cure (3.0; 2.1-4.4; P < 0.001). The activity of corpus and antral gastritis was not associated with the magnitude of H+ change induced by omeprazole.
CONCLUSION
The increased pH produced by omeprazole during H. pylori infection is likely to be due to neutralizing substances produced by H. pylori and not to H. pylori-induced gastritis.
Omeprazole treatment produces lower intragastric pH values 4 weeks after cure of Helicobacter pylori infection than before. We therefore investigated the effect of healing H. pylori-associated gastritis on intragastric pH in the presence and in the absence of omeprazole therapy.
METHODS
Before and on day 8 of omeprazole, 20 mg once daily, 24-h intragastric pH-recordings were performed in 14 subjects with H. pylori infection and repeated 4 and 52 weeks after cure of infection. Gastritis severity in corpus and antrum was graded by using a modified Sydney system.
RESULTS
In the absence of omeprazole administration, median 24-h pH values before cure did not differ from those 4 and 52 weeks after cure. On day 8 of omeprazole administration, 24-h pH values were much higher before cure (median, 5.15; 95% confidence interval (CI), 4.3-6.0) than 4 weeks (3.6; 2.1-4.4; P < 0.001) and 52 weeks after cure (3.0; 2.1-4.4; P < 0.001). The activity of corpus and antral gastritis was not associated with the magnitude of H+ change induced by omeprazole.
CONCLUSION
The increased pH produced by omeprazole during H. pylori infection is likely to be due to neutralizing substances produced by H. pylori and not to H. pylori-induced gastritis.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.3109/00365529609036903
- PMID 8976005
- Persistent URL
- https://sonar.ch/global/documents/93428
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