Journal article
JAK protein tyrosine kinases: their role in cytokine signalling.
- Ziemiecki A Laboratory for Clinical and Experimental Research, University of Berne, Switzerland.
- Harpur AG
- Wilks AF
- 1994-06-01
Published in:
- Trends in cell biology. - 1994
English
Protein tyrosine kinases (PTKs) are integral components of the cellular machinery that mediates the transduction and/or processing of many extra- and intracellular signals. Members of the JAK family of intracellular PTKs (JAK1, JAK2 and TYK2) are characterized by the possession of a PTK-related domain and five additional homology domains, in addition to a classical PTK domain. An important breakthrough in the understanding of JAK kinases function(s) has come from the recent observations that many cytokine receptors compensate for their lack of a PTK domain by utilizing members of the JAK family for signal transduction.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/0962-8924(94)90143-0
- PMID 14731679
- Persistent URL
- https://sonar.ch/global/documents/986
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