2026-05-01T19:04:28Z
https://sonar.ch/oai2d
oai:sonar.ch:258196
2025-10-24T21:46:55Z
Cho I
Ó Hartaigh B
Gransar H
Valenti V
Lin FY
Achenbach S
Berman DS
Budoff MJ
Callister TQ
Al-Mallah MH
Cademartiri F
Chinnaiyan K
Chow BJW
Dunning AM
DeLago A
Villines TC
Hadamitzky M
Hausleiter J
Leipsic J
Shaw LJ
Kaufmann PA
Cury RC
Feuchtner G
Kim YJ
Maffei E
Raff G
Pontone G
Andreini D
Chang HJ
Min JK
2017
BACKGROUND AND AIMS
Coronary artery calcium (CAC) scoring is a predictor of future adverse clinical events, and a surrogate measure of overall coronary artery plaque burden. Coronary computed tomographic angiography (CCTA) is a contrast-enhanced method that allows for visualization of plaque as well as whether that plaque causes luminal narrowing. To date, the prognosis of individuals with CAC but without stenosis has not been reported. We explored the prevalence of CAC>0 and its prognostic utility for future mortality for patients without luminal narrowing by CCTA.
METHODS
From 17 sites in 9 countries, we identified patients without known coronary artery disease, who underwent CAC scoring and CCTA, and were followed for >3 years. CCTA was graded for % stenosis according to a modified American Heart Association 16-segment model. We calculated hazard ratios (HR) with 95% confidence intervals (95% CI) for incident mortality and compared risk of death for patients as a function of presence or absence of CAC and presence or absence of luminal narrowing by CCTA.
RESULTS
Among 6656 patients who underwent CCTA and CAC scoring, 399 patients (6.0%) had no coronary luminal narrowing but CAC>0. During a median follow-up of 5.1 years (IQR: 3.9-5.9 years), 456 deaths occurred. Compared to individuals without luminal narrowing or CAC, individuals without luminal narrowing but CAC>0 were older, more likely to be male and had higher rates of diabetes, hypertension, and dyslipidemia. Individuals without luminal narrowing but CAC experienced a 2-fold increased risk of mortality, with increasing risk of mortality with higher CAC score. Following adjustment, incident death persisted (HR, 1.8; 95% CI, 1.1-2.9, p = 0.02) among patients without luminal narrowing but with CAC>0 compared with patients whose CACS = 0. Individuals without luminal narrowing but CAC ≥100 had mortality risks similar to individuals with non-obstructive CAD (0 < stenosis<50%) by CCTA [HR 2.5 (95% CI 1.3-4.9) and 2.2 (95% CI 1.6-3.0), respectively].
CONCLUSIONS
Patients without luminal narrowing but with CAC experience greater risk of 5-year mortality. Patients with CAC score ≥100 and no coronary luminal narrowing experience death rates similar to those with non-obstructive CAD.
application/pdf
https://sonar.ch/global/documents/258196
eng
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2016.12.006
info:eu-repo/semantics/altIdentifier/pmid/28385391
info:eu-repo/semantics/openAccess
Atherosclerosis. - 2017
Coronary artery calcium scoring
Coronary artery disease
Coronary computed tomographic angiography
Adult
Aged
Asymptomatic Diseases
Computed Tomography Angiography
Coronary Angiography
Coronary Artery Disease
Coronary Stenosis
Coronary Vessels
Europe
Female
Humans
Israel
Kaplan-Meier Estimate
Male
Middle Aged
North America
Predictive Value of Tests
Prevalence
Prognosis
Proportional Hazards Models
Prospective Studies
Registries
Risk Factors
Time Factors
Vascular Calcification
Prognostic implications of coronary artery calcium in the absence of coronary artery luminal narrowing.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258187
2025-10-24T21:46:54Z
Bach DR
Tzovara A
Vunder J
2018
Learning to predict threat is a fundamental ability of many biological organisms, and a laboratory model for anxiety disorders. Interfering with such memories in humans would be of high clinical relevance. On the basis of studies in cell cultures and slice preparations, it is hypothesised that synaptic remodelling required for threat learning involves the extracellular enzyme matrix metalloproteinase (MMP) 9. However, in vivo evidence for this proposal is lacking. Here we investigate human Pavlovian fear conditioning under the blood-brain barrier crossing MMP inhibitor doxycyline in a pre-registered, randomised, double-blind, placebo-controlled trial. We find that recall of threat memory, measured with fear-potentiated startle 7 days after acquisition, is attenuated by ~60% in individuals who were under doxycycline during acquisition. This threat memory impairment is also reflected in increased behavioural surprise signals to the conditioned stimulus during subsequent re-learning, and already late during initial acquisition. Our findings support an emerging view that extracellular signalling pathways are crucially required for threat memory formation. Furthermore, they suggest novel pharmacological methods for primary prevention and treatment of posttraumatic stress disorder.
application/pdf
https://sonar.ch/global/documents/258187
eng
info:eu-repo/semantics/altIdentifier/doi/10.1038/mp.2017.65
info:eu-repo/semantics/altIdentifier/pmid/28373691
info:eu-repo/semantics/openAccess
Molecular psychiatry. - 2018
Adult
Conditioning, Classical
Double-Blind Method
Doxycycline
Fear
Female
Humans
Learning
Male
Matrix Metalloproteinase Inhibitors
Memory
Mental Recall
Reflex, Startle
Young Adult
Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258126
2025-10-24T21:46:50Z
Dolder PC
Schmid Y
Steuer AE
Kraemer T
Rentsch KM
Hammann F
Liechti ME
2017
BACKGROUND AND OBJECTIVE
Lysergic acid diethylamide (LSD) is used recreationally and in clinical research. The aim of the present study was to characterize the pharmacokinetics and exposure-response relationship of oral LSD.
METHODS
We analyzed pharmacokinetic data from two published placebo-controlled, double-blind, cross-over studies using oral administration of LSD 100 and 200 µg in 24 and 16 subjects, respectively. The pharmacokinetics of the 100-µg dose is shown for the first time and data for the 200-µg dose were reanalyzed and included. Plasma concentrations of LSD, subjective effects, and vital signs were repeatedly assessed. Pharmacokinetic parameters were determined using compartmental modeling. Concentration-effect relationships were described using pharmacokinetic-pharmacodynamic modeling.
RESULTS
Geometric mean (95% confidence interval) maximum plasma concentration values of 1.3 (1.2-1.9) and 3.1 (2.6-4.0) ng/mL were reached 1.4 and 1.5 h after administration of 100 and 200 µg LSD, respectively. The plasma half-life was 2.6 h (2.2-3.4 h). The subjective effects lasted (mean ± standard deviation) 8.2 ± 2.1 and 11.6 ± 1.7 h for the 100- and 200-µg LSD doses, respectively. Subjective peak effects were reached 2.8 and 2.5 h after administration of LSD 100 and 200 µg, respectively. A close relationship was observed between the LSD concentration and subjective response within subjects, with moderate counterclockwise hysteresis. Half-maximal effective concentration values were in the range of 1 ng/mL. No correlations were found between plasma LSD concentrations and the effects of LSD across subjects at or near maximum plasma concentration and within dose groups.
CONCLUSIONS
The present pharmacokinetic data are important for the evaluation of clinical study findings (e.g., functional magnetic resonance imaging studies) and the interpretation of LSD intoxication. Oral LSD presented dose-proportional pharmacokinetics and first-order elimination up to 12 h. The effects of LSD were related to changes in plasma concentrations over time, with no evidence of acute tolerance.
TRIAL REGISTRATION
NCT02308969, NCT01878942.
application/pdf
https://sonar.ch/global/documents/258126
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/s40262-017-0513-9
info:eu-repo/semantics/altIdentifier/pmid/28197931
info:eu-repo/semantics/openAccess
Clinical pharmacokinetics. - 2017
Autonomic Effect
Drug Effect
Lysergic Acid Diethylamide
Psilocybin
Subjective Effect
Administration, Oral
Adult
Affect
Blood Pressure
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Female
Half-Life
Hallucinogens
Healthy Volunteers
Heart Rate
Humans
Lysergic Acid Diethylamide
Male
Middle Aged
Young Adult
Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258123
2025-10-24T21:46:49Z
Wiegand A
Credé A
Tschammler C
Attin T
Tauböck TT
2017
OBJECTIVES
This study aimed to analyse loss of enamel worn against composite, leucite glass ceramic or enamel antagonists under non-erosive and alternating or simultanuous erosive-attritive conditions.
MATERIALS AND METHODS
Flat human enamel specimens were loaded (1 Hz, 300 g loading weight, each subgroup n = 12) with antagonists made from a hybrid-composite (Z250, 3 M Espe), a nano-composite (Filtek Supreme XTE, 3 M Espe), leucite glass ceramic (IPS Empress CAD LT, Ivoclar Vivadent) or enamel. Specimens were either submitted to mechanical loading in mineral solution (60 s) or to loading under alternating or simultaneous erosive conditions. For alternating erosion-attrition, specimens were eroded by citric acid (pH 2.6, 60 s) and then loaded with the respective antagonist for 60s. For simultaneous erosion-attrition, specimens were loaded with the respective antagonist while being immersed in citric acid (pH 2.6, 60 s). After each cycle, specimens were stored in water for 1 h. After 18 cycles, enamel loss was calculated profilometrically and statistically analysed by two-way ANOVA and Tukey's post-hoc tests (p < 0.05).
RESULTS
Enamel loss (μm, mean ± standard deviation) was significantly highest for simultaneous erosion-attrition (ceramic 9.4 ± 1.1, hybrid-composite 8.3 ± 0.7, nano-composite 7.8 ± 1.2, enamel 7.4 ± 0.8) followed by alternating erosion-attrition (ceramic 3.5 ± 0.5, hybrid-composite 2.1 ± 0.8, nano-composite 1.0 ± 0.2, enamel 2.5 ± 0.7) and attrition in mineral solution (ceramic 0.5 ± 0.3, hybrid composite 0.3 ± 0.1, nano composite 0.1 ± 0.2, enamel 0.1 ± 0.1). Ceramic antagonists resulted in significantly higher loss than the remaining antagonistic materials when alternating or simultaneous erosion-attrition was performed.
CONCLUSION
Erosive conditions had a massive impact on enamel worn against different antagonistic materials, with simultaneous erosive-attritive conditions being more detrimental than alternating erosive-attritive conditions.
CLINICAL RELEVANCE
Enamel wear by antagonistic restorative materials is significantly influenced by erosive conditions.
application/pdf
https://sonar.ch/global/documents/258123
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00784-017-2071-9
info:eu-repo/semantics/altIdentifier/pmid/28185090
info:eu-repo/semantics/openAccess
Clinical oral investigations. - 2017
Attrition
Ceramic
Composite
Erosion
Profilometry
Aluminum Silicates
Ceramics
Composite Resins
Dental Enamel
Dental Porcelain
Humans
In Vitro Techniques
Materials Testing
Surface Properties
Tooth Erosion
Tooth Wear
Enamel wear by antagonistic restorative materials under erosive conditions.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258025
2025-10-24T21:46:38Z
Studer D
Gnaegi H
2000
With the aim to minimize compression artefacts in ultrathin sections, coincident with the stroke direction, we have invented an oscillating diamond knife. Results and theoretical considerations explaining its function are discussed. During conventional ultrathin sectioning the resultant compression is in the order of 20-35% of section height. This holds true for sections of samples embedded into Lowicryl HM20 and of the polymer polystyrene, cut with a 45 degrees diamond knife and floated on water. The oscillating knife reduces this compression almost completely. It consists of a diamond knife on which a low voltage piezoelectric translator (piezo) is mounted, which oscillates when the piezo is driven by an alternating voltage source. No additional cutting artefacts were observed in the micrographs when they were compared with sections produced without oscillating the knife.
https://sonar.ch/global/documents/258025
eng
info:eu-repo/semantics/altIdentifier/doi/10.1046/j.1365-2818.2000.00638.x
info:eu-repo/semantics/altIdentifier/pmid/10620152
Journal of microscopy. - 2000
Acrylic Resins
Animals
Dinoflagellida
Microscopy, Electron
Microtomy
Plastic Embedding
Polystyrenes
Minimal compression of ultrathin sections with use of an oscillating diamond knife.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258108
2025-10-24T21:47:00Z
Scheffel H
Pfammatter T
Wildi S
Bauerfeind P
Marincek B
Alkadhi H
2007
This study was conducted to determine the ability of multi-detector-row computed tomography (CT) to identify the source and etiology of acute gastrointestinal bleeding. Eighteen patients with acute upper (n = 10) and lower (n = 8) gastrointestinal bleeding underwent 4-detector-row CT (n = 6), 16-detector-row CT (n = 11), and 64-slice CT (n = 1) with an arterial and portal venous phase of contrast enhancement. Unenhanced scans were performed in nine patients. CT scans were reviewed to determine conspicuity of bleeding source, underlying etiology, and for potential causes of false-negative prospective interpretations. Bleeding sources were prospectively identified with CT in 15 (83%) patients, and three (17%) bleeding sources were visualized in retrospect, allowing the characterization of all sources of bleeding with CT. Contrast extravasation was demonstrated with CT in all 11 patients with severe bleeding, but only in 1 of 7 patients with mild bleeding. The etiology could not be identified on unenhanced CT scans in any patient, whereas arterial-phase and portal venous-phase CT depicted etiology in 15 (83%) patients. Underlying etiology was correctly identified in all eight patients with mild GI bleeding. Multi-detector-row CT enables the identification of bleeding source and precise etiology in patients with acute gastrointestinal bleeding.
application/pdf
https://sonar.ch/global/documents/258108
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00330-006-0514-9
info:eu-repo/semantics/altIdentifier/pmid/17171511
info:eu-repo/semantics/openAccess
European radiology. - 2007
Acute Disease
Adult
Aged
Angiography
Female
Gastrointestinal Hemorrhage
Humans
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Retrospective Studies
Tomography, X-Ray Computed
Acute gastrointestinal bleeding: detection of source and etiology with multi-detector-row CT.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258128
2025-10-24T21:47:02Z
de Boer RA
De Keulenaer G
Bauersachs J
Brutsaert D
Cleland JG
Diez J
Du XJ
Ford P
Heinzel FR
Lipson KE
McDonagh T
Lopez-Andres N
Lunde IG
Lyon AR
Pollesello P
Prasad SK
Tocchetti CG
Mayr M
Sluijter JPG
Thum T
Tschöpe C
Zannad F
Zimmermann WH
Ruschitzka F
Filippatos G
Lindsey ML
Maack C
Heymans S
2019
Fibrosis is a pivotal player in heart failure development and progression. Measurements of (markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with heart failure, and its treatment may be effective in preventing heart failure and its progression. A lack of pathophysiological insights and uniform definitions has hampered the research in fibrosis and heart failure. The Translational Research Committee of the Heart Failure Association discussed several aspects of fibrosis in their workshop. Early insidious perturbations such as subclinical hypertension or inflammation may trigger first fibrotic events, while more dramatic triggers such as myocardial infarction and myocarditis give rise to full blown scar formation and ongoing fibrosis in diseased hearts. Aging itself is also associated with a cardiac phenotype that includes fibrosis. Fibrosis is an extremely heterogeneous phenomenon, as several stages of the fibrotic process exist, each with different fibrosis subtypes and a different composition of various cells and proteins - resulting in a very complex pathophysiology. As a result, detection of fibrosis, e.g. using current cardiac imaging modalities or plasma biomarkers, will detect only specific subforms of fibrosis, but cannot capture all aspects of the complex fibrotic process. Furthermore, several anti-fibrotic therapies are under investigation, but such therapies generally target aspecific aspects of the fibrotic process and suffer from a lack of precision. This review discusses the mechanisms and the caveats and proposes a roadmap for future research.
application/pdf
https://sonar.ch/global/documents/258128
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/ejhf.1406
info:eu-repo/semantics/altIdentifier/pmid/30714667
info:eu-repo/semantics/openAccess
European journal of heart failure. - 2019
Biomarkers
Fibroblast
Fibrosis
Heart failure
Imaging
Matrix
Prognosis
Biomarkers
Cardiac Imaging Techniques
Disease Management
Europe
Extracellular Matrix Proteins
Fibrosis
Heart Failure
Humans
Myocardium
Prognosis
Research
Societies, Medical
Translational Medical Research
Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:258112
2025-10-24T21:47:01Z
Filli L
Piccirelli M
Kenkel D
Boss A
Manoliu A
Andreisek G
Bhat H
Runge VM
Guggenberger R
2016
PURPOSE
To investigate the feasibility of MR diffusion tensor imaging (DTI) of the median nerve using simultaneous multi-slice echo planar imaging (EPI) with blipped CAIPIRINHA.
MATERIALS AND METHODS
After federal ethics board approval, MR imaging of the median nerves of eight healthy volunteers (mean age, 29.4 years; range, 25-32) was performed at 3 T using a 16-channel hand/wrist coil. An EPI sequence (b-value, 1,000 s/mm(2); 20 gradient directions) was acquired without acceleration as well as with twofold and threefold slice acceleration. Fractional anisotropy (FA), mean diffusivity (MD) and quality of nerve tractography (number of tracks, average track length, track homogeneity, anatomical accuracy) were compared between the acquisitions using multivariate ANOVA and the Kruskal-Wallis test.
RESULTS
Acquisition time was 6:08 min for standard DTI, 3:38 min for twofold and 2:31 min for threefold acceleration. No differences were found regarding FA (standard DTI: 0.620 ± 0.058; twofold acceleration: 0.642 ± 0.058; threefold acceleration: 0.644 ± 0.061; p ≥ 0.217) and MD (standard DTI: 1.076 ± 0.080 mm(2)/s; twofold acceleration: 1.016 ± 0.123 mm(2)/s; threefold acceleration: 0.979 ± 0.153 mm(2)/s; p ≥ 0.074). Twofold acceleration yielded similar tractography quality compared to standard DTI (p > 0.05). With threefold acceleration, however, average track length and track homogeneity decreased (p = 0.004-0.021).
CONCLUSION
Accelerated DTI of the median nerve is feasible. Twofold acceleration yields similar results to standard DTI.
KEY POINTS
• Standard DTI of the median nerve is limited by its long acquisition time. • Simultaneous multi-slice acquisition is a new technique for accelerated DTI. • Accelerated DTI of the median nerve yields similar results to standard DTI.
https://sonar.ch/global/documents/258112
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00330-015-3985-8
info:eu-repo/semantics/altIdentifier/pmid/26373759
European radiology. - 2016
Diffusion tensor imaging
Diffusion tractography
Echo-planar imaging
Median nerve
Simultaneous multi-slice
Adult
Anisotropy
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Echo-Planar Imaging
Female
Healthy Volunteers
Humans
Male
Median Nerve
Accelerated magnetic resonance diffusion tensor imaging of the median nerve using simultaneous multi-slice echo planar imaging with blipped CAIPIRINHA.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260661
2025-10-24T21:57:51Z
Turkington HL
Juozapaitis M
Tsolakos N
Corrales-Aguilar E
Schwemmle M
Hale BG
2018
Recently, two influenza A virus (FLUAV) genomes were identified in Central and South American bats. These sequences exhibit notable divergence from classical FLUAV counterparts, and functionally, bat FLUAV glycoproteins lack canonical receptor binding and destroying activity. Nevertheless, other features that distinguish these viruses from classical FLUAVs have yet to be explored. Here, we studied the viral nonstructural protein NS1, a virulence factor that modulates host signaling to promote efficient propagation. Like all FLUAV NS1 proteins, bat FLUAV NS1s bind double-stranded RNA and act as interferon antagonists. Unexpectedly, we found that bat FLUAV NS1s are unique in being unable to bind host p85β, a regulatory subunit of the cellular metabolism-regulating enzyme, phosphoinositide 3-kinase (PI3K). Furthermore, neither bat FLUAV NS1 alone nor infection with a chimeric bat FLUAV efficiently activates Akt, a PI3K effector. Structure-guided mutagenesis revealed that the bat FLUAV NS1-p85β interaction can be reengineered (in a strain-specific manner) by changing two to four NS1 residues (96L, 99M, 100I, and 145T), thereby creating a hydrophobic patch. Notably, ameliorated p85β-binding is insufficient for bat FLUAV NS1 to activate PI3K, and a chimeric bat FLUAV expressing NS1 with engineered hydrophobic patch mutations exhibits cell-type-dependent, but species-independent, propagation phenotypes. We hypothesize that bat FLUAV hijacking of PI3K in the natural bat host has been selected against, perhaps because genes in this metabolic pathway were differentially shaped by evolution to suit the unique energy use strategies of this flying mammal. These data expand our understanding of the enigmatic functional divergence between bat FLUAVs and classical mammalian and avian FLUAVs.IMPORTANCE The potential for novel influenza A viruses to establish infections in humans from animals is a source of continuous concern due to possible severe outbreaks or pandemics. The recent discovery of influenza A-like viruses in bats has raised questions over whether these entities could be a threat to humans. Understanding unique properties of the newly described bat influenza A-like viruses, such as their mechanisms to infect cells or how they manipulate host functions, is critical to assess their likelihood of causing disease. Here, we characterized the bat influenza A-like virus NS1 protein, a key virulence factor, and found unexpected functional divergence of this protein from counterparts in other influenza A viruses. Our study dissects the molecular changes required by bat influenza A-like virus NS1 to adopt classical influenza A virus properties and suggests consequences of bat influenza A-like virus infection, potential future evolutionary trajectories, and intriguing virus-host biology in bat species.
application/pdf
https://sonar.ch/global/documents/260661
eng
info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.02097-17
info:eu-repo/semantics/altIdentifier/pmid/29237829
info:eu-repo/semantics/openAccess
Journal of virology. - 2018
AKT signaling
RNA virus
bats
influenza
virulence factors
A549 Cells
Amino Acid Substitution
Animals
Base Sequence
Cell Line
Chiroptera
Disease Outbreaks
Dogs
HEK293 Cells
Host-Pathogen Interactions
Humans
Influenza A virus
Influenza, Human
Madin Darby Canine Kidney Cells
Metabolic Networks and Pathways
Models, Molecular
Orthomyxoviridae Infections
Phosphatidylinositol 3-Kinases
Protein Binding
Protein Conformation
Protein Interaction Domains and Motifs
Proto-Oncogene Proteins c-akt
RNA, Double-Stranded
Signal Transduction
Species Specificity
Viral Nonstructural Proteins
Virulence Factors
Unexpected Functional Divergence of Bat Influenza Virus NS1 Proteins.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260593
2025-10-24T21:58:12Z
Myśliwec A
Skalska M
Knechtle B
Nikolaidis PT
Rosemann T
Szmigiero-Kawko M
Lejk A
Jastrzębska J
Radzimiński Ł
Wakuluk D
Czapiewska K
López-Sánchez GF
Jastrzębski Z
2020
The main purpose of this study was to investigate the differences in glycaemic reaction in response to various physical activities in 20 young boys (14.4 ± 1.6 years) with type 1 diabetes mellitus (T1DM) and with either vitamin D deficiency or with suboptimal levels of vitamin D. Participants were divided into two groups (deficiency group-DG, n = 10; suboptimal group-SG, n = 10) according to their vitamin D levels. All patients performed aerobic and mixed (aerobic-anaerobic) physical efforts. During the exercise, the respiratory responses and glucose levels were monitored. Biochemical blood analyses were performed before each physical effort. The oxygen consumption was not significantly lower in SG during both aerobic and mixed effort (4.0% and 5.6%, respectively). The glycated haemoglobin (HbA1c) level was higher by 6.1% and the total daily dose of insulin (DDI) was higher by 18.4% in the DG. The differences were not statistically significant. Patients with lower vitamin D levels demonstrated an insignificantly higher glycaemic variability during days with both aerobic and mixed exercises. An appropriate vitamin D concentration in T1DM patients' blood may constitute a prophylactic factor for hyperglycaemia during anaerobic training and hypoglycaemia during aerobic training.
application/pdf
https://sonar.ch/global/documents/260593
eng
info:eu-repo/semantics/altIdentifier/doi/10.3390/nu12020454
info:eu-repo/semantics/altIdentifier/pmid/32054009
info:eu-repo/semantics/openAccess
Nutrients. - 2020
blood glucose
exercise intensity
oxygen consumption
serum 25(OH)D
type 1 diabetes
Acute Responses to Low and High Intensity Exercise in Type 1 Diabetic Adolescents in Relation to Their Level of Serum 25(OH)D.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260547
2025-10-24T21:58:05Z
Aebi C
Theiler F
Aebischer CC
Schoeni MH
2000
BACKGROUND
Cystic fibrosis (CF) is associated with the appearance of serum autoantibodies directed against bactericidal/permeability-increasing protein (BPI).
OBJECTIVES
To determine the age-specific seroprevalence rates of anti-BPI-IgG and IgA in a population of patients with CF and to correlate anti-BPI antibody concentrations with microbial respiratory tract colonization and pulmonary function variables at the time of serum sampling and 6 years thereafter.
METHODS
Determination of BPI antibodies of the IgG and IgA isotypes using a commercial enzyme-linked immunosorbent assay in sera of a CF serum bank of 1992; correlation of anti-BPI antibody concentrations with age, clinical score, pulmonary function variables in 1992 and 1998, total serum immunoglobulin isotype concentrations and respiratory tract colonization with Pseudomonas aeruginosa and Aspergillus spp.
RESULTS
Seventy-one patients (age in 1992, 14.1 +/- 7.5 years) were studied. Reactivities for anti-BPI-IgG and IgA were found in 28 (39%) and 26 (37%) patients, respectively. The seroprevalence of anti-BPI-IgA, but not IgG, increased significantly with age. P. aeruginosa colonization was associated with elevated concentrations of anti-BPI-IgG (P = 0.003) and IgA (P = 0.037). There were significant negative correlations between pulmonary function variables (vital capacity, forced expiratory volume in 1 s) in 1992 and 1998, respectively, and concentrations of anti-BPI-IgG or IgA in a multiple regression analysis. Anti-BPI-IgG, but not IgA, remained significantly associated with P. aeruginosa colonization (P = 0.006) and with reduced vital capacity (P = 0.01) in 1998 after correction for total serum isotype concentration.
CONCLUSIONS
Anti-BPI-IgG are strongly associated with concurrent P. aeruginosa colonization and with long term restrictive pulmonary function abnormalities.
https://sonar.ch/global/documents/260547
eng
info:eu-repo/semantics/altIdentifier/doi/10.1097/00006454-200003000-00006
info:eu-repo/semantics/altIdentifier/pmid/10749460
The Pediatric infectious disease journal. - 2000
Adolescent
Adult
Age Factors
Antimicrobial Cationic Peptides
Aspergillus
Autoantibodies
Blood Proteins
Cystic Fibrosis
Female
Humans
Immunoglobulin A
Immunoglobulin G
Male
Membrane Proteins
Pseudomonas aeruginosa
Respiratory Tract Infections
Seroepidemiologic Studies
Autoantibodies directed against bactericidal/permeability-increasing protein in patients with cystic fibrosis: association with microbial respiratory tract colonization.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260540
2025-10-24T21:58:04Z
Lövblad KO
Plüschke W
Remonda L
Gruber-Wiest D
Do DD
Barth A
Kniemeyer HW
Bassetti C
Mattle HP
Schroth G
2000
Carotid stenting is increasingly considered as treatment for carotid artery disease. A reliable noninvasive method is desirable for assessing the safety of the procedure. Diffusion-weighted MRI (DWI) is sensitive to early brain ischaemia which becoming widely available and might therefore serve this purpose. We prospectively studied 19 patients referred for investigation of carotid artery disease by echo-planar whole-brain DWI before and within 24 h of stenting. The images obtained at a high b value were examined by two independent blinded reviewers for new high-signal areas consistent with ischaemia. We found that 15 patients had no new changes after stenting. One patient showed enlargement of a posterior watershed lesion after the procedure, which correlated with an increase in neurological deficit. Three other patients had presumed small embolic infarcts on DWI; two were asymptomatic and one had weakness at the hand that corresponded to an embolic infarct with a lesion on DWI in the hand notch. There were no false- positive or -negative results on DWI, when compared to clinical findings. DWI is thus a new method that can demonstrate neurologically silent or asymptomatic infants. It can be used to help to assess the safety and efficacy of neurovascular intervention.
https://sonar.ch/global/documents/260540
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/s002340050032
info:eu-repo/semantics/altIdentifier/pmid/10663492
Neuroradiology. - 2000
Adult
Aged
Aged, 80 and over
Brain Infarction
Brain Ischemia
Carotid Stenosis
Diffusion
Echo-Planar Imaging
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
Intracranial Embolism
Magnetic Resonance Imaging
Middle Aged
Monitoring, Intraoperative
Prospective Studies
Radiology, Interventional
Reproducibility of Results
Safety
Single-Blind Method
Stents
Diffusion-weighted MRI for monitoring neurovascular interventions.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260612
2025-10-24T21:57:49Z
Hartnack S
Alobo G
Kankya C
2017
https://sonar.ch/global/documents/260612
eng
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tmaid.2017.11.001
info:eu-repo/semantics/altIdentifier/pmid/29128441
Travel medicine and infectious disease. - 2017
One health
Toxocara
Toxocariasis
Africa
Animals
Enzyme-Linked Immunosorbent Assay
Humans
One Health
Toxocariasis
Zoonoses
Toxocariasis in Africa: A One Health perspective.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260564
2025-10-24T21:58:09Z
Azzi A
Aratri E
Boscoboinik D
Clément S
Ozer N
Ricciarelli R
Spycher S
Stocker A
2001
https://sonar.ch/global/documents/260564
eng
info:eu-repo/semantics/altIdentifier/doi/10.1159/000059476
info:eu-repo/semantics/altIdentifier/pmid/11125575
Bibliotheca nutritio et dieta. - 2001
Dose-Response Relationship, Drug
Gene Expression Regulation
Humans
In Vitro Techniques
Time Factors
Vitamins
Vitamins and regulation of gene expression.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260857
2025-10-24T21:58:58Z
Aaij R
Abellán Beteta C
Adeva B
Adinolfi M
Aidala CA
Ajaltouni Z
Akar S
Albicocco P
Albrecht J
Alessio F
Alexander M
Alfonso Albero A
Alkhazov G
Alvarez Cartelle P
Alves AA
Amato S
Amhis Y
An L
Anderlini L
Andreassi G
Andreotti M
Andrews JE
Archilli F
Arnau Romeu J
Artamonov A
Artuso M
Arzymatov K
Aslanides E
Atzeni M
Audurier B
Bachmann S
Back JJ
Baker S
Balagura V
Baldini W
Baranov A
Barlow RJ
Barsuk S
Barter W
Bartolini M
Baryshnikov F
Batozskaya V
Batsukh B
Battig A
Battista V
Bay A
Bedeschi F
Bediaga I
Beiter A
Bel LJ
Belin S
Beliy N
Bellee V
Belloli N
Belous K
Belyaev I
Bencivenni G
Ben-Haim E
Benson S
Beranek S
Berezhnoy A
Bernet R
Berninghoff D
Bertholet E
Bertolin A
Betancourt C
Betti F
Bettler MO
Bezshyiko I
Bhasin S
Bhom J
Bieker MS
Bifani S
Billoir P
Birnkraut A
Bizzeti A
Bjørn M
Blago MP
Blake T
Blanc F
Blusk S
Bobulska D
Bocci V
Boente Garcia O
Boettcher T
Bondar A
Bondar N
Borghi S
Borisyak M
Borsato M
Boubdir M
Bowcock TJV
Bozzi C
Braun S
Brodski M
Brodzicka J
Brossa Gonzalo A
Brundu D
Buchanan E
Buonaura A
Burr C
Bursche A
Butter JS
Buytaert J
Byczynski W
Cadeddu S
Cai H
Calabrese R
Cali S
Calladine R
Calvi M
Calvo Gomez M
Camboni A
Campana P
Campora Perez DH
Capriotti L
Carbone A
Carboni G
Cardinale R
Cardini A
Carniti P
Carvalho Akiba K
Casse G
Cattaneo M
Cavallero G
Cenci R
Chapman MG
Charles M
Charpentier P
Chatzikonstantinidis G
Chefdeville M
Chekalina V
Chen C
Chen S
Chitic SG
Chobanova V
Chrzaszcz M
Chubykin A
Ciambrone P
Cid Vidal X
Ciezarek G
Cindolo F
Clarke PEL
Clemencic M
Cliff HV
Closier J
Coco V
Coelho JAB
Cogan J
Cogneras E
Cojocariu L
Collins P
Colombo T
Comerma-Montells A
Contu A
Coombs G
Coquereau S
Corti G
Costa Sobral CM
Couturier B
Cowan GA
Craik DC
Crocombe A
Cruz Torres M
Currie R
Da Silva CL
Dall'Occo E
Dalseno J
D'Ambrosio C
Danilina A
d'Argent P
Davis A
De Aguiar Francisco O
De Bruyn K
De Capua S
De Cian M
De Miranda JM
De Paula L
De Serio M
De Simone P
de Vries JA
Dean CT
Dean W
Decamp D
Del Buono L
Delaney B
Dembinski HP
Demmer M
Dendek A
Derkach D
Deschamps O
Desse F
Dettori F
Dey B
Di Canto A
Di Nezza P
Didenko S
Dijkstra H
Dordei F
Dorigo M
Dos Reis AC
Dosil Suárez A
Douglas L
Dovbnya A
Dreimanis K
Dufour L
Dujany G
Durante P
Durham JM
Dutta D
Dzhelyadin R
Dziewiecki M
Dziurda A
Dzyuba A
Easo S
Egede U
Egorychev V
Eidelman S
Eisenhardt S
Eitschberger U
Ekelhof R
Eklund L
Ely S
Ene A
Escher S
Esen S
Evans T
Falabella A
Färber C
Farley N
Farry S
Fazzini D
Féo M
Fernandez Declara P
Fernandez Prieto A
Ferrari F
Ferreira Lopes L
Ferreira Rodrigues F
Ferreres Sole S
Ferro-Luzzi M
Filippov S
Fini RA
Fiorini M
Firlej M
Fitzpatrick C
Fiutowski T
Fleuret F
Fontana M
Fontanelli F
Forty R
Franco Lima V
Frank M
Frei C
Fu J
Funk W
Gabriel E
Gallas Torreira A
Galli D
Gallorini S
Gambetta S
Gan Y
Gandelman M
Gandini P
Gao Y
Garcia Martin LM
García Pardiñas J
Garcia Plana B
Garra Tico J
Garrido L
Gascon D
Gaspar C
Gazzoni G
Gerick D
Gersabeck E
Gersabeck M
Gershon T
Gerstel D
Ghez P
Gibson V
Girard OG
Gironella Gironell P
Giubega L
Gizdov K
Gligorov VV
Göbel C
Golubkov D
Golutvin A
Gomes A
Gorelov IV
Gotti C
Govorkova E
Grabowski JP
Graciani Diaz R
Granado Cardoso LA
Graugés E
Graverini E
Graziani G
Grecu A
Greim R
Griffith P
Grillo L
Gruber L
Gruberg Cazon BR
Gu C
Gushchin E
Guth A
Guz Y
Gys T
Hadavizadeh T
Hadjivasiliou C
Haefeli G
Haen C
Haines SC
Hamilton B
Han Q
Han X
Hancock TH
Hansmann-Menzemer S
Harnew N
Harrison T
Hasse C
Hatch M
He J
Hecker M
Heinicke K
Heister A
Hennessy K
Henry L
Heß M
Heuel J
Hicheur A
Hidalgo Charman R
Hill D
Hilton M
Hopchev PH
Hu J
Hu W
Huang W
Huard ZC
Hulsbergen W
Humair T
Hushchyn M
Hutchcroft D
Hynds D
Ibis P
Idzik M
Ilten P
Inglessi A
Inyakin A
Ivshin K
Jacobsson R
Jakobsen S
Jalocha J
Jans E
Jashal BK
Jawahery A
Jiang F
John M
Johnson D
Jones CR
Joram C
Jost B
Jurik N
Kandybei S
Karacson M
Kariuki JM
Karodia S
Kazeev N
Kecke M
Keizer F
Kelsey M
Kenzie M
Ketel T
Khanji B
Kharisova A
Khurewathanakul C
Kim KE
Kirn T
Kirsebom VS
Klaver S
Klimaszewski K
Koliiev S
Kolpin M
Kopecna R
Koppenburg P
Kostiuk I
Kot O
Kotriakhova S
Kozeiha M
Kravchuk L
Kreps M
Kress F
Kretzschmar S
Krokovny P
Krupa W
Krzemien W
Kucewicz W
Kucharczyk M
Kudryavtsev V
Kunde GJ
Kuonen AK
Kvaratskheliya T
Lacarrere D
Lafferty G
Lai A
Lancierini D
Lanfranchi G
Langenbruch C
Latham T
Lazzeroni C
Le Gac R
Lefèvre R
Leflat A
Lemaitre F
Leroy O
Lesiak T
Leverington B
Li H
Li PR
Li X
Li Y
Li Z
Liang X
Likhomanenko T
Lindner R
Lionetto F
Lisovskyi V
Liu G
Liu X
Loh D
Loi A
Longstaff I
Lopes JH
Loustau G
Lovell GH
Lucchesi D
Lucio Martinez M
Luo Y
Lupato A
Luppi E
Lupton O
Lusiani A
Lyu X
Machefert F
Maciuc F
Macko V
Mackowiak P
Maddrell-Mander S
Maev O
Maguire K
Maisuzenko D
Majewski MW
Malde S
Malecki B
Malinin A
Maltsev T
Malygina H
Manca G
Mancinelli G
Marangotto D
Maratas J
Marchand JF
Marconi U
Marin Benito C
Marinangeli M
Marino P
Marks J
Marshall PJ
Martellotti G
Martinelli M
Martinez Santos D
Martinez Vidal F
Massafferri A
Materok M
Matev R
Mathad A
Mathe Z
Matiunin V
Matteuzzi C
Mattioli KR
Mauri A
Maurice E
Maurin B
McCann M
McNab A
McNulty R
Mead JV
Meadows B
Meaux C
Meinert N
Melnychuk D
Merk M
Merli A
Michielin E
Milanes DA
Millard E
Minard MN
Minzoni L
Mitzel DS
Mödden A
Mogini A
Moise RD
Mombächer T
Monroy IA
Monteil S
Morandin M
Morello G
Morello MJ
Moron J
Morris AB
Mountain R
Mu H
Muheim F
Mukherjee M
Mulder M
Müller D
Müller J
Müller K
Müller V
Murphy CH
Murray D
Naik P
Nakada T
Nandakumar R
Nandi A
Nanut T
Nasteva I
Needham M
Neri N
Neubert S
Neufeld N
Newcombe R
Nguyen TD
Nguyen-Mau C
Nieswand S
Niet R
Nikitin N
Nolte NS
Oblakowska-Mucha A
Obraztsov V
Ogilvy S
O'Hanlon DP
Oldeman R
Onderwater CJG
Osborn JD
Ossowska A
Otalora Goicochea JM
Ovsiannikova T
Owen P
Oyanguren A
Pais PR
Pajero T
Palano A
Palutan M
Panshin G
Papanestis A
Pappagallo M
Pappalardo LL
Parker W
Parkes C
Passaleva G
Pastore A
Patel M
Patrignani C
Pearce A
Pellegrino A
Penso G
Pepe Altarelli M
Perazzini S
Pereima D
Perret P
Pescatore L
Petridis K
Petrolini A
Petrov A
Petrucci S
Petruzzo M
Pietrzyk B
Pietrzyk G
Pikies M
Pili M
Pinci D
Pinzino J
Pisani F
Piucci A
Placinta V
Playfer S
Plews J
Plo Casasus M
Polci F
Poli Lener M
Poliakova M
Poluektov A
Polukhina N
Polyakov I
Polycarpo E
Pomery GJ
Ponce S
Popov A
Popov D
Poslavskii S
Price E
Prouve C
Pugatch V
Puig Navarro A
Pullen H
Punzi G
Qian W
Qin J
Quagliani R
Quintana B
Raab NV
Rachwal B
Rademacker JH
Rama M
Ramos Pernas M
Rangel MS
Ratnikov F
Raven G
Ravonel Salzgeber M
Reboud M
Redi F
Reichert S
Reiss F
Remon Alepuz C
Ren Z
Renaudin V
Ricciardi S
Richards S
Rinnert K
Robbe P
Robert A
Rodrigues AB
Rodrigues E
Rodriguez Lopez JA
Roehrken M
Roiser S
Rollings A
Romanovskiy V
Romero Vidal A
Roth JD
Rotondo M
Rudolph MS
Ruf T
Ruiz Vidal J
Saborido Silva JJ
Sagidova N
Saitta B
Salustino Guimaraes V
Sanchez Gras C
Sanchez Mayordomo C
Sanmartin Sedes B
Santacesaria R
Santamarina Rios C
Santimaria M
Santovetti E
Sarpis G
Sarti A
Satriano C
Satta A
Saur M
Savrina D
Schael S
Schellenberg M
Schiller M
Schindler H
Schmelling M
Schmelzer T
Schmidt B
Schneider O
Schopper A
Schreiner HF
Schubiger M
Schulte S
Schune MH
Schwemmer R
Sciascia B
Sciubba A
Semennikov A
Sepulveda ES
Sergi A
Serra N
Serrano J
Sestini L
Seuthe A
Seyfert P
Shapkin M
Shears T
Shekhtman L
Shevchenko V
Shmanin E
Siddi BG
Silva Coutinho R
Silva de Oliveira L
Simi G
Simone S
Skiba I
Skidmore N
Skwarnicki T
Slater MW
Smeaton JG
Smith E
Smith IT
Smith M
Soares M
Soares Lavra L
Sokoloff MD
Soler FJP
Souza De Paula B
Spaan B
Spadaro Norella E
Spradlin P
Stagni F
Stahl M
Stahl S
Stefko P
Stefkova S
Steinkamp O
Stemmle S
Stenyakin O
Stepanova M
Stevens H
Stocchi A
Stone S
Stracka S
Stramaglia ME
Straticiuc M
Straumann U
Strokov S
Sun J
Sun L
Sun Y
Swientek K
Szabelski A
Szumlak T
Szymanski M
Tang Z
Tekampe T
Tellarini G
Teubert F
Thomas E
Tilley MJ
Tisserand V
T'Jampens S
Tobin M
Tolk S
Tomassetti L
Tonelli D
Tou DY
Tourinho Jadallah Aoude R
Tournefier E
Traill M
Tran MT
Trisovic A
Tsaregorodtsev A
Tuci G
Tully A
Tuning N
Ukleja A
Usachov A
Ustyuzhanin A
Uwer U
Vagner A
Vagnoni V
Valassi A
Valat S
Valenti G
van Beuzekom M
Van Hecke H
van Herwijnen E
Van Hulse CB
van Tilburg J
van Veghel M
Vasiliev A
Vazquez Gomez R
Vazquez Regueiro P
Vázquez Sierra C
Vecchi S
Velthuis JJ
Veltri M
Venkateswaran A
Vernet M
Veronesi M
Vesterinen M
Viana Barbosa JV
Vieira D
Vieites Diaz M
Viemann H
Vilasis-Cardona X
Vitkovskiy A
Vitti M
Volkov V
Vollhardt A
Vom Bruch D
Voneki B
Vorobyev A
Vorobyev V
Voropaev N
Waldi R
Walsh J
Wang J
Wang J
Wang M
Wang Y
Wang Z
Ward DR
Wark HM
Watson NK
Websdale D
Weiden A
Weisser C
Whitehead M
Wilkinson G
Wilkinson M
Williams I
Williams M
Williams MRJ
Williams T
Wilson FF
Winn M
Wislicki W
Witek M
Wormser G
Wotton SA
Wyllie K
Xiao D
Xie Y
Xing H
Xu A
Xu L
Xu M
Xu Q
Xu Z
Xu Z
Yang Z
Yang Z
Yao Y
Yeomans LE
Yin H
Yu J
Yuan X
Yushchenko O
Zarebski KA
Zavertyaev M
Zeng M
Zhang D
Zhang L
Zhang S
Zhang WC
Zhang Y
Zhelezov A
Zheng Y
Zhu X
Zhukov V
Zonneveld JB
Zucchelli S
2019
The production of charged hadrons within jets recoiling against a Z boson is measured in proton-proton collision data at sqrt[s]=8 TeV recorded by the LHCb experiment. The charged-hadron structure of the jet is studied longitudinally and transverse to the jet axis for jets with transverse momentum p_{T}>20 GeV and in the pseudorapidity range 2.5<η<4. These are the first measurements of jet hadronization at these forward rapidities and also the first where the jet is produced in association with a Z boson. In contrast to previous hadronization measurements at the Large Hadron Collider, which are dominated by gluon jets, these measurements probe predominantly light-quark jets which are found to be more longitudinally and transversely collimated with respect to the jet axis when compared to the previous gluon dominated measurements. Therefore, these results provide valuable information on differences between quarks and gluons regarding nonperturbative hadronization dynamics.
application/pdf
https://sonar.ch/global/documents/260857
eng
info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.123.232001
info:eu-repo/semantics/altIdentifier/pmid/31868452
info:eu-repo/semantics/openAccess
Physical review letters. - 2019
General Physics and Astronomy
Measurement of Charged Hadron Production in Z-Tagged Jets in Proton-Proton Collisions at sqrt[s]=8 TeV.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260771
2025-10-24T21:58:49Z
Yousefi N
Hassel K
Flatberg KI
Kemppainen P
Trucchi E
Shaw AJ
Kyrkjeeide MO
Szövényi P
Stenøien HK
2017
PREMISE OF THE STUDY
Populations with phenotypic polymorphism in discrete characters may be good models for investigating genome evolution and speciation. Sphagnum magellanicum Brid. is found throughout the northern hemisphere, and despite considerable variation in morphological characters, it is considered one of the least taxonomically controversial peatmoss species. We have observed two main morphs of the species associated with different microhabitats. Here we investigated the genomic and environmental basis of this intraspecific morphological variation.
METHODS
We conducted transplant and common garden experiments to test whether the two morphs are genetically differentiated. We then used RAD-sequencing to quantify the genomic divergence between the morphs and approximate Bayesian computation (ABC) to infer the most likely demographic scenario explaining the genome-wide differentiation of the two morphs.
KEY RESULTS
We found that genomic differentiation between the two morphs is unexpectedly high and that several of the differentiated morphological characters have a genetic basis. Using simulation approaches, we found support for a scenario of ancient divergence followed by recent secondary contact.
CONCLUSIONS
We show that the two morphs represent the two main genetic clusters previously found worldwide. Our results demonstrate that relatively minor morphological differentiation in a presumed phenotypically plastic peatmoss may be associated with massive divergence across the genome.
application/pdf
https://sonar.ch/global/documents/260771
eng
info:eu-repo/semantics/altIdentifier/doi/10.3732/ajb.1700163
info:eu-repo/semantics/altIdentifier/pmid/28754766
info:eu-repo/semantics/openAccess
American journal of botany. - 2017
RAD-sequencing
bryophytes
common garden experiment
genetic divergence
microhabitats
northern peatlands
phenotypic polymorphism
population genetics
transplant experiment
Divergent evolution and niche differentiation within the common peatmoss Sphagnum magellanicum.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260707
2025-10-24T21:58:52Z
Fuchs J
Bessire K
Weiler S
2019
This case report describes the effect of an envenomation by the Beautiful Pit Viper Trimeresurus venustus (or Cryptelytrops venustus), which is a green pit viper native to Thailand and Malaysia. A previously healthy 60-year-old snake breeder with no relevant medical history was bitten by his adult T. venustus in the third finger of his right hand while taking it out of the feeding box. The bite was painful and swelling progressed to include his whole hand within an hour after the bite. He was treated symptomatically with pre-emptive antibiotics and analgesics, never developed any hematological disorders such as coagulopathy and bleeding or disseminated intravascular coagulation and was discharged 26 hours after the bite. The clinical course in our patient matched two other well-documented cases reported to our Poisons Centre, and one further case presented as a conference-poster. All patients recovered with symptomatic therapy and never required antivenom. Therefore, bites by T. venustus seem to present with less severe symptoms compared to other Trimeresurus species.
https://sonar.ch/global/documents/260707
eng
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.toxicon.2019.03.019
info:eu-repo/semantics/altIdentifier/pmid/30902684
Toxicon : official journal of the International Society on Toxinology. - 2019
Coagulopathy
Cryptelytrops venustus
Local symptoms
Trimeresurus venustus
Analgesics
Animals
Anti-Bacterial Agents
Crotalid Venoms
Edema
Finger Injuries
Humans
Male
Middle Aged
Occupational Injuries
Pain
Snake Bites
Trimeresurus
A confirmed bite by a Beautiful Pit Viper (Trimeresurus venustus) resulting in local symptoms.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260942
2025-10-24T21:59:46Z
Lun XK
Zanotelli VR
Wade JD
Schapiro D
Tognetti M
Dobberstein N
Bodenmiller B
2017
Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the properties of signaling networks is limited. Here we couple mass-cytometry-based single-cell analysis with overexpression of tagged signaling proteins to study the dependence of signaling relationships and dynamics on protein node abundance. Focusing on the epidermal growth factor receptor (EGFR) signaling network in HEK293T cells, we analyze 20 signaling proteins during a 1-h EGF stimulation time course using a panel of 35 antibodies. Data analysis with BP-R2, a measure that quantifies complex signaling relationships, reveals abundance-dependent network states and identifies novel signaling relationships. Further, we show that upstream signaling proteins have abundance-dependent effects on downstream signaling dynamics. Our approach elucidates the influence of node abundance on signal transduction networks and will further our understanding of signaling in health and disease.
application/pdf
https://sonar.ch/global/documents/260942
eng
info:eu-repo/semantics/altIdentifier/doi/10.1038/nbt.3770
info:eu-repo/semantics/altIdentifier/pmid/28092656
info:eu-repo/semantics/openAccess
Nature biotechnology. - 2017
Computer Simulation
Epidermal Growth Factor
ErbB Receptors
Flow Cytometry
Gene Expression Profiling
Gene Expression Regulation
HEK293 Cells
Humans
Models, Biological
Proteome
Signal Transduction
Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261077
2025-10-24T21:59:40Z
Schlumpf M
Reichrath J
Lehmann B
Sigmundsdottir H
Feldmeyer L
Hofbauer GF
Lichtensteiger W
2010
Since exposure to sunlight is a main factor in the development of non-melanoma skin cancer and there are associations between malignant melanoma and short-term intense ultraviolet (UV) exposure, particularly burning in childhood, strict protection from UV-radiation is recommended. However, up to 90% of all requisite vitamin D has to be formed within the skin through the action of the sun-a serious problem, for a connection between vitamin D deficiency, demonstrated in epidemiological studies, and various types of cancer and other diseases has been confirmed. A UVB-triggered skin autonomous vitamin D(3) synthesis pathway has recently been described, producing the active Vitamin D metabolite calcitriol. This cutaneous vitamin D(3) pathway is unique. Keratinocytes and dendritic cells can convert vitamin D to calcitriol. Cutaneous T cells activated in the presence of calcitriol express the chemokine receptor CCR10 attracting them to the chemokine CCL27 that keratinocytes express selectively in the epidermis, and migrate from dermal layers of the skin to the epidermis under UV radiation. Thus, calcitriol has endocrine roles beyond its calciotropic action, including cell growth and cancer prevention. Therefore, strict sun protection procedures to prevent skin cancer may induce the risk of vitamin D deficiency. As there is evidence that the protective effect of less intense solar radiation can outweigh its mutagenic effect, better balanced approaches to sun protection should be sought.
application/pdf
https://sonar.ch/global/documents/261077
eng
info:eu-repo/semantics/altIdentifier/doi/10.4161/derm.2.1.12016
info:eu-repo/semantics/altIdentifier/pmid/21547144
info:eu-repo/semantics/openAccess
Dermato-endocrinology. - 2010
cancer
immune system (skin)
photo therapy
sun protection
ultraviolet radiation
vitamin D
vitamin D synthesis (skin)
Fundamental questions to sun protection: A continuous education symposium on vitamin D, immune system and sun protection at the University of Zürich.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261105
2025-10-24T21:59:42Z
Rüst CA
Knechtle B
Rosemann T
2012
BACKGROUND
This case report describes an experienced open-water ultra-endurance athlete swimming in water of 9.9°C for 6 h and 2 min.
METHODS
Before the swim, anthropometric characteristics such as body mass, body height, skinfold thicknesses, and body fat were determined. During and after the swim, body core (rectum) and body surface (forearm and calf) temperatures were continuously recorded.
RESULTS
The swimmer (53 years old, 110.5 kg body mass, 1.76 m body height, 34.9% body fat, and a body mass index of 35.7 kg/m2) achieved a total distance of 15 km while swimming at a mean speed of 2.48 km/h, equal to 0.69 m/s, in water of 9.9°C. Body core temperature was at 37.8°C before the swim, increased to a maximum of 38.1°C after approximately 20 min of swimming, and then decreased continuously to 36.3°C upon finishing the swim. The lowest body core temperature was 36.0°C between 35 and 60 min after finishing the swim. Sixty minutes after the swim, the body core temperature continuously rose to 36.5°C where it remained. At the forearm, the temperature dropped to 19.6°C after approximately 36 min of swimming and decreased to 19.4°C by the end of the swim. The lowest temperature at the forearm was 17.6°C measured at approximately 47 min before the athlete stopped swimming. At the calf, the temperature dropped to 13.0°C after approximately 24 min of swimming and decreased to 11.9°C at the end of the swim. The lowest temperature measured at the calf was 11.1°C approximately 108 min after the start. In both the forearm and the calf, the skin temperature continuously increased after the swim.
CONCLUSIONS
This case report shows that (1) it is possible to swim for 6 h in water of 9.9°C and that (2) the athlete did not suffer from hypothermia under these circumstances. The high body mass index, high body fat, previous experience, and specific preparation of the swimmer are the most probable explanations for these findings.
application/pdf
https://sonar.ch/global/documents/261105
eng
info:eu-repo/semantics/altIdentifier/doi/10.1186/2046-7648-1-8
info:eu-repo/semantics/altIdentifier/pmid/23849461
info:eu-repo/semantics/openAccess
Extreme physiology & medicine. - 2012
Changes in body core and body surface temperatures during prolonged swimming in water of 10°C-a case report.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260940
2025-10-24T21:59:45Z
Invernizzi A
Nguyen V
Teo K
Barthelmes D
Fung A
Vincent A
Gillies M
2019
PURPOSE
To compare 5-year real-world outcomes of eyes with classic and occult choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (anti-VEGF) injections.
DESIGN
Retrospective analysis from a prospectively designed observational database.
METHODS
Treatment-naïve eyes diagnosed with occult or minimally or predominantly classic CNV that commenced anti-VEGF treatment between January 2007 and December 2012 were identified from a registry of neovascular age-related macular degeneration (nAMD) treatment outcomes. Baseline characteristics, visual acuity (VA) at 5 years, change in VA, time to first inactivation, number of injections, and proportion of visits graded with active nAMD over the 5 years were compared between the 3 groups.
RESULTS
A total of 1929 eyes from 1730 subjects (1196 occult, 289 minimally classic, and 444 predominantly classic CNV) were analyzed. Baseline VA (mean [standard deviation]) was higher in occult CNVs (56.9 [17.4] letters) than in minimally (52.9 [19.7] letters) and predominantly (49.1 [19.9] letters) classic CNVs (P = .003 and P < .0001, respectively). VA change was similar across the groups. At 5 years eyes with occult CNVs still had better VA than other CNVs. Age, lesion size, and baseline VA, but not CNV type, significantly affected final VA in the multivariate model. Predominantly classic CNVs became inactive sooner and were overall less active than other CNV types. The number of injections received was similar across the groups.
CONCLUSIONS
Eyes with occult CNVs had overall a better VA than other CNVs. The difference in final VA was not significant after adjusting for baseline VA. Five-year outcomes and treatment patterns were not affected by the lesion type.
https://sonar.ch/global/documents/260940
eng
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ajo.2019.03.001
info:eu-repo/semantics/altIdentifier/pmid/30862501
American journal of ophthalmology. - 2019
Aged
Aged, 80 and over
Angiogenesis Inhibitors
Blindness
Choroid
Choroidal Neovascularization
Disease Progression
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Intravitreal Injections
Male
Middle Aged
Prospective Studies
Ranibizumab
Retinal Vessels
Time Factors
Tomography, Optical Coherence
Treatment Outcome
Vascular Endothelial Growth Factor A
Visual Acuity
Five-Year Real-World Outcomes of Occult and Classic Choroidal Neovascularization: Data From the Fight Retinal Blindness! Project.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260927
2025-10-24T21:59:44Z
Plate KH
Wieser HG
Yasargil MG
Wiestler OD
1993
During the period between 1976 and 1990, 247 patients with pharmaco-resistant complex partial seizures and a documented unilateral epileptogenic area in the mediobasal temporal lobe underwent a selective amygdalo-hippocampectomy procedure at our institution. Biopsy specimens from 224 patients (91% of the total) were available for a retrospective histopathological and immunohistochemical review. The tissue specimens of 23 patients without evidence for a macroscopic lesion have been used for neurochemical studies and could not be evaluated histopathologically. The most common temporal lobe pathology were neoplasms in 126 patients, i.e. 56%. Tumor entities observed included 23 astrocytomas (18% of all tumors), 17 gangliogliomas (13%), 15 oligodendrogliomas (12%), 15 cases of glioblastoma multiforme (12%), 13 pilocytic astrocytomas (10%), 12 oligo-astrocytomas (10%), 11 anaplastic astrocytomas (9%) and 20 tumors of various other histologies. In 23 specimens (10%), small foci of oligodendroglia-like clear cells were found. The frequent association of these foci with low-grade gliomas or neural hamartomas raises the possibility that these structures may serve as precursor lesion for neuroepithelial tumors of the temporal lobe. In 98 cases, pathological changes of non-neoplastic origin were encountered. The most common diagnoses in this group included hippocampal gliosis/sclerosis (49 cases, 22%) and vascular malformations (20 cases, 9%). Hamartomas, i.e. focal accumulations of dysplastic neuro-glial cells were diagnosed in 14 patients (6%). In only four cases have we not been able to detect any microscopic pathology. These results indicate that a high proportion of pharmaco-therapy-resistant complex-partial seizures are caused by neoplasms of the temporal lobe, some of which appear to be strikingly overrepresented in this group of patients.
https://sonar.ch/global/documents/260927
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00228577
info:eu-repo/semantics/altIdentifier/pmid/8310793
Acta neuropathologica. - 1993
Adolescent
Adult
Aged
Brain Diseases
Brain Neoplasms
Child
Child, Preschool
Epilepsy, Temporal Lobe
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Retrospective Studies
Neuropathological findings in 224 patients with temporal lobe epilepsy.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260950
2025-10-24T21:59:48Z
Spang, Anne
https://sonar.ch/global/documents/260950
eng
info:eu-repo/semantics/altIdentifier/doi/10.3410/f.1002087.22054
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. - Faculty Opinions Ltd. - 2001
Faculty Opinions recommendation of Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260955
2025-10-24T21:59:49Z
Liu, Cunlan
Ueno, Tomoo
Kuse, Sachiyo
Saito, Fumi
Nitta, Takeshi
Piali, Luca
Nakano, Hideki
Kakiuchi, Terutaka
Lipp, Martin
Hollander, Georg A.
Takahama, Yousuke
<jats:title>Abstract</jats:title>
<jats:p>During embryonic development, T-lymphoid precursor cells colonize the thymus. Chemoattraction by the fetal thymus is thought to mediate T-precursor cell colonization. However, the molecules that attract T-precursor cells to the thymus remain unclear. By devising time-lapse visualization in culture, the present results show that alymphoid fetal thymus lobes attract T-precursor cells from fetal liver or fetal blood. CD4–CD8–CD25–CD44+ fetal thymocytes retained the activity to specifically re-enter the thymus. The attraction was predominantly due to I-A–expressing thymic epithelial cells and was mediated by pertussis toxin-sensitive G-protein signals. Among the chemokines produced by the fetal thymus, CCL21, CCL25, and CXCL12 could attract CD4–CD8–CD25–CD44+ fetal thymocytes. However, fetal thymus colonization was markedly diminished by neutralizing antibodies specific for CCL21 and CCL25, but not affected by anti-CXCL12 antibody. Fetal thymus colonization was partially defective in CCL21-deficient plt/plt mice and was further diminished by anti-CCL25 antibody. These results indicate that CCL21 is involved in the recruitment of T-cell precursors to the fetal thymus and suggest that the combination of CCL21 and CCL25 plays a major role in fetal thymus colonization.</jats:p>
application/pdf
https://sonar.ch/global/documents/260955
eng
info:eu-repo/semantics/altIdentifier/doi/10.1182/blood-2004-04-1369
info:eu-repo/semantics/altIdentifier/issn/0006-4971
info:eu-repo/semantics/openAccess
Blood. - American Society of Hematology. - 2005, vol. 105, no. 1, p. 31-39
Immunology
Cell Biology
Biochemistry
Hematology
The role of CCL21 in recruitment of T-precursor cells to fetal thymi
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261001
2025-10-24T21:59:57Z
Kurmann, J.
Müller, G.
Thomas, H.
Puga, M. W.
Beck, H.
application/pdf
https://sonar.ch/global/documents/261001
eng
info:eu-repo/semantics/altIdentifier/doi/10.1063/1.329586
info:eu-repo/semantics/altIdentifier/issn/0021-8979
info:eu-repo/semantics/openAccess
Journal of Applied Physics. - AIP Publishing. - 1981, vol. 52, no. 3, p. 1968-1970
General Physics and Astronomy
Anisotropic quantum spin chains
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261007
2025-10-24T21:59:57Z
Bounameaux, H
Duckert, F
Walter, M
Bounameaux, Y
2018
<jats:title>Summary</jats:title><jats:p>At III levels were measured with six methods in 36 people: 10 healthy controls, 10 women taking a progestagen Lynestrenol and 16 women taking a combined oestrogen-progestagen contraceptive pill.</jats:p><jats:p>The reproducibility and the sensitivity of these methods as well as the correlation between methods were studied.</jats:p><jats:p>The Hensen and Loeliger technique had a poor reproducibility and the results obtained with the Howie technique were not in good correlation with those obtained with the other methods, especially in the group taking oral contraceptives. The two amidolytic methods using chromogenic substrates were found to be very accurate for antithrombin III activity determination. The rocket Immunoelectrophoresis was more accurate and more practical than the radial immunodiffusion.</jats:p><jats:p>With all methods - except the one of Howie–the 10 women taking progestagen Lynestrenol and the 16 taking combined oestrogen-progestagen had a low AT III and differed significantly from the 10 normals tested. No difference was observed between women taking progestagen only or an oestrogen-progestagen combination.</jats:p>
https://sonar.ch/global/documents/261007
eng
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0038-1646734
info:eu-repo/semantics/altIdentifier/issn/0340-6245
Thrombosis and Haemostasis. - Georg Thieme Verlag KG. - 1978, vol. 39, no. 03, p. 607-615
Hematology
The Determination of Antithrombin III
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260991
2025-10-24T21:59:54Z
Funk, A
2018
https://sonar.ch/global/documents/260991
eng
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0038-1671581
Frauenheilkunde im Fokus: wissenschaftlich fundiert und der Qualität verpflichtet. - Georg Thieme Verlag KG. - 2018
Enhanced myometrial vascularity and persistence of beta hCG: grey area between retained products of conception, AV-malformation and gestational trophoblastic disease
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261102
2025-10-24T22:00:29Z
Stipp, M.
Fügenschuh, B.
Gromet, L. P.
Stünitz, H.
Schmid, S. M.
2004
application/pdf
https://sonar.ch/global/documents/261102
eng
info:eu-repo/semantics/altIdentifier/doi/10.1029/2003tc001515
info:eu-repo/semantics/altIdentifier/issn/0278-7407
info:eu-repo/semantics/openAccess
Tectonics. - American Geophysical Union (AGU). - 2004, vol. 23, no. 3, p. n/a-n/a
Geochemistry and Petrology
Geophysics
Contemporaneous plutonism and strike-slip faulting: A case study from the Tonale fault zone north of the Adamello pluton (Italian Alps)
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261092
2025-10-24T22:00:29Z
Rivera-Rivera, Leonardo A.
Schubert, Tilman
Knobloch, Gesine
Turski, Patrick A.
Wieben, Oliver
Reeder, Scott B.
Johnson, Kevin M.
2017
application/pdf
https://sonar.ch/global/documents/261092
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/mrm.26975
info:eu-repo/semantics/altIdentifier/issn/0740-3194
info:eu-repo/semantics/openAccess
Magnetic Resonance in Medicine. - Wiley. - 2017, vol. 79, no. 6, p. 3072-3081
Comparison of ferumoxytol-based cerebral blood volume estimates using quantitative R1
and R2* relaxometry
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261236
2025-10-24T22:00:27Z
Lee, Yeon Joo
Neofytos, Dionysios
Kim, Seong Jin
Cheteyan, Leslie
Huang, Yao-Ting
Papadopoulos, Esperanza B.
Jakubowski, Ann A.
Papanicolaou, Genovefa A.
2018
application/pdf
https://sonar.ch/global/documents/261236
eng
info:eu-repo/semantics/altIdentifier/doi/10.1111/tid.12977
info:eu-repo/semantics/altIdentifier/issn/1398-2273
info:eu-repo/semantics/openAccess
Transplant Infectious Disease. - Wiley. - 2018, vol. 20, no. 6, p. e12977
Efficacy of brincidofovir as prophylaxis against HSV and VZV in hematopoietic cell transplant recipients
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261114
2025-10-24T22:00:30Z
Giezendanner, Stphanie
Jung, Corinna
Banderet, Hans-Ruedi
Otte, Ina Carola
Gudat, Heike
Haller, Dagmar M
Elger, Bernice Simone
Zemp, Elisabeth
Bally, Klaus
2018
application/pdf
https://sonar.ch/global/documents/261114
fre
info:eu-repo/semantics/altIdentifier/doi/10.4414/fms.2018.03286
info:eu-repo/semantics/altIdentifier/issn/1661-6146
info:eu-repo/semantics/openAccess
Forum Médical Suisse ‒ Swiss Medical Forum. - EMH Swiss Medical Publishers, Ltd.. - 2018
Kompetenz in Palliative Care im medizinischen Alltag
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261202
2025-10-24T22:00:24Z
Foroozandeh M
Jeannerat D
2015
Resolution enhancement is a long-sought goal in NMR spectroscopy. In conventional multidimensional NMR experiments, such as the (1) H-(13) C HSQC, the resolution in the indirect dimensions is typically 100 times lower as in 1D spectra because it is limited by the experimental time. Reducing the spectral window can significantly increase the resolution but at the cost of ambiguities in frequencies as a result of spectral aliasing. Fortunately, this information is not completely lost and can be retrieved using methods in which chemical shifts are encoded in the aliased spectra and decoded after processing to reconstruct high-resolution (1) H-(13) C HSQC spectrum with full spectral width and a resolution similar to that of 1D spectra. We applied a new reconstruction method, RHUMBA (reconstruction of high-resolution using multiplet built on aliased spectra), to spectra obtained from the differential evolution for non-ambiguous aliasing-HSQC and the new AMNA (additional modulation for non-ambiguous aliasing)-HSQC experiments. The reconstructed spectra significantly facilitate both manual and automated spectral analyses and structure elucidation based on heteronuclear 2D experiments. The resolution is enhanced by two orders of magnitudes without the usual complications due to spectral aliasing.
https://sonar.ch/global/documents/261202
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/mrc.4283
info:eu-repo/semantics/altIdentifier/pmid/26289946
Magnetic resonance in chemistry : MRC. - 2015
13C
1H
2D spectra reconstruction
AMNA
HSQC
NASCA
NMR
RHUMBA
fast method
spectral aliasing
Reconstruction of full high-resolution HSQC using signal split in aliased spectra.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261142
2025-10-24T22:00:33Z
Enz TJ
Goldblum D
Gerber N
2018
https://sonar.ch/global/documents/261142
eng
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0043-122484
info:eu-repo/semantics/altIdentifier/pmid/29390232
Klinische Monatsblatter fur Augenheilkunde. - 2018
Administration, Topical
Aged
Ascorbic Acid
Burns, Chemical
Eye
Eye Burns
Humans
Male
Topical Ascorbate Administration in Severe Ocular Burns.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261246
2025-10-24T22:00:46Z
Knechtle B
Nikolaidis PT
Onywera VO
Zingg MA
Rosemann T
Rüst CA
2016
In major marathon races such as the 'World Marathon Majors', female and male East African runners particularly from Ethiopia and Kenya are the fastest. However, whether this trend appears for female and male Ethiopians and Kenyans at recreational level runners (i.e. races at national level) and in shorter road races (e.g. in half-marathon races) has not been studied yet. Thus, the aim of the present study was to examine differences in the performance and the age of female and male runners from East Africa (i.e. Ethiopians and Kenyans) between half- and full marathons. Data from 508,108 athletes (125,894 female and 328,430 male half-marathoners and 10,205 female and 43,489 male marathoners) originating from 126 countries and competing between 1999 and 2014 in all road-based half-marathons and marathons held in one country (Switzerland) were analysed using Chi square (χ(2)) tests, mixed-effects regression analyses and one-way analyses of variance. In half-marathons, 48 women (0.038 %) and 63 men (0.019 %) were from Ethiopia and 80 women (0.063 %) and 134 men (0.040 %) from Kenya. In marathons, three women (0.029 %) and 15 men (0.034 %) were from Ethiopia and two women (0.019 %) and 33 men (0.075 %) from Kenya. There was no statistically significant association between the nationality of East Africans and the format of a race. In both women and men, the fastest race times in half-marathons and marathons were achieved by East African runners (p < 0.001). Ethiopian and Kenyan runners were the youngest in both sexes and formats of race (p < 0.001). In summary, women and men from Ethiopia and Kenya, despite they accounted for <0.1 % in half-marathons and marathons, achieved the fastest race times and were the youngest in both half-marathons and marathons. These findings confirmed in the case of half-marathon the trend previously observed in marathon races for a better performance and a younger age in East African runners from Ethiopia and Kenya.
application/pdf
https://sonar.ch/global/documents/261246
eng
info:eu-repo/semantics/altIdentifier/doi/10.1186/s40064-016-1915-0
info:eu-repo/semantics/altIdentifier/pmid/27026917
info:eu-repo/semantics/openAccess
SpringerPlus. - 2016
Age
Athletes
Endurance
Long-distance
Nationality
Running
Sex
Male and female Ethiopian and Kenyan runners are the fastest and the youngest in both half and full marathon.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261326
2025-10-24T22:00:48Z
Deken MA
Gadiot J
Jordanova ES
Lacroix R
van Gool M
Kroon P
Pineda C
Geukes Foppen MH
Scolyer R
Song JY
Verbrugge I
Hoeller C
Dummer R
Haanen JB
Long GV
Blank CU
2016
Immunotherapy of advanced melanoma with CTLA-4 or PD-1/PD-L1 checkpoint blockade induces in a proportion of patients long durable responses. In contrast, targeting the MAPK-pathway by selective BRAF and MEK inhibitors induces high response rates, but most patients relapse. Combining targeted therapy with immunotherapy is proposed to improve the long-term outcomes of patients. Preclinical data endorsing this hypothesis are accumulating. Inhibition of the PI3K-Akt-mTOR pathway may be a promising treatment option to overcome resistance to MAPK inhibition and for additional combination with immunotherapy. We therefore evaluated to which extent dual targeting of the MAPK and PI3K-Akt-mTOR pathways affects tumor immune infiltrates and whether it synergizes with PD-1 checkpoint blockade in a BRAFV600E/PTEN-/--driven melanoma mouse model. Short-term dual BRAF + MEK inhibition enhanced tumor immune infiltration and improved tumor control when combined with PD-1 blockade in a CD8+ T cell dependent manner. Additional PI3K inhibition did not impair tumor control or immune cell infiltration and functionality. Analysis of on-treatment samples from melanoma patients treated with BRAF or BRAF + MEK inhibitors indicates that inhibitor-mediated T cell infiltration occurred in all patients early after treatment initiation but was less frequent found in on-treatment biopsies beyond day 15. Our findings provide a rationale for clinical testing of short-term BRAF + MEK inhibition in combination with immune checkpoint blockade, currently implemented at our institutes. Additional PI3K inhibition could be an option for BRAF + MEK inhibitor resistant patients that receive targeted therapy in combination with immune checkpoint blockade.
application/pdf
https://sonar.ch/global/documents/261326
eng
info:eu-repo/semantics/altIdentifier/doi/10.1080/2162402X.2016.1238557
info:eu-repo/semantics/altIdentifier/pmid/28123875
info:eu-repo/semantics/openAccess
Oncoimmunology. - 2016
Anti-PD-1
BRAF
MAPK
MEK
PI3K
checkpoint blockade
immunotherapy
mTOR
melanoma
targeted therapy
Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261268
2025-10-24T22:00:46Z
Yim S
Khare D
Kang J
Hwang JU
Liang W
Martinoia E
Zhang D
Kang B
Lee Y
2016
Two Arabidopsis ABC transporters, ABCG1 and ABCG16, are expressed in the tapetal layer, specifically after postmeiotic microspore release, and play important roles in pollen surface development. The male gametophytic cells of terrestrial plants, the pollen grains, travel far before fertilization, and thus require strong protective layers, which take the form of a pollen coat and a pollen wall. The protective surface structures are generated by the tapetum, the tissue surrounding the developing gametophytes. Many ABC transporters, including Arabidopsis thaliana ABCG1 and ABCG16, have been shown to play essential roles in the development of such protective layers. However, the details of the mechanism of their function remain to be clarified. In this study, we show that ABCG1 and ABCG16 are localized at the plasma membrane of tapetal cells, specifically after postmeiotic microspore release, and play critical roles in the postmeiotic stages of male gametophyte development. Consistent with this stage-specific expression, the abcg1 abcg16 double knockout mutant exhibited defects in pollen development after postmeiotic microspore release; their microspores lacked intact nexine and intine layers, exhibited defects in pollen mitosis I, displayed ectopic deposits of arabinogalactan proteins, failed to complete cytokinesis, and lacked sperm cells. Interestingly, the double mutant exhibited abnormalities in the internal structures of tapetal cells, too; the storage organelles of tapetal cells, tapetosomes and elaioplasts, were morphologically altered. Thus, this work reveals that the lack of ABCG1 and ABCG16 at the tapetal cell membrane causes a broad range of defects in pollen, as well as in tapetal cells themselves. Furthermore, these results suggest that normal pollen surface development is necessary for normal development of the pollen cytoplasm.
https://sonar.ch/global/documents/261268
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00299-016-2001-3
info:eu-repo/semantics/altIdentifier/pmid/27271688
Plant cell reports. - 2016
ABC transporter
Elaioplast
Pollen surface
Postmeiotic development
Tapetosome
ATP Binding Cassette Transporter, Subfamily G
Arabidopsis
Arabidopsis Proteins
Cell Membrane
Cell Wall
Meiosis
Membrane Proteins
Mitosis
Mucoproteins
Mutation
Plant Proteins
Pollen
Postmeiotic development of pollen surface layers requires two Arabidopsis ABCG-type transporters.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261165
2025-10-24T22:00:37Z
Cai, Xiaofeng
Shi, Yi-Ming
Pöhlmann, Nicole
Revermann, Ole
Bahner, Isabel
Pidot, Sacha J.
Wesche, Frank
Lackner, Helmut
Büchel, Claudia
Kaiser, Marcel
Richter, Christian
Schwalbe, Harald
Stinear, Timothy P.
Zeeck, Axel
Bode, Helge B.
2017
https://sonar.ch/global/documents/261165
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/ange.201701223
info:eu-repo/semantics/altIdentifier/issn/0044-8249
Angewandte Chemie. - Wiley. - 2017, vol. 129, no. 18, p. 5027-5031
Struktur und Biosynthese der Isatropolone, bioaktiver und Amin-reaktiver fluoreszierender Naturstoffe aus Streptomyces
Gö66
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261455
2025-10-24T22:01:33Z
Guerit, Laure
Barrier, Laurie
Jolivet, Marc
Fu, Bihong
Métivier, François
2016
application/pdf
https://sonar.ch/global/documents/261455
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/esp.3890
info:eu-repo/semantics/altIdentifier/issn/0197-9337
info:eu-repo/semantics/openAccess
Earth Surface Processes and Landforms. - Wiley. - 2016, vol. 41, no. 8, p. 1088-1106
Denudation intensity and control in the Chinese Tian Shan: new constraints from mass balance on catchment-alluvial fan systems
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261275
2025-10-24T22:01:23Z
Sahakian, Marlyne
Rau, Henrike
Wallenborn, Grégoire
2020
<jats:p> This article demonstrates how a cultural reading of consumption that focuses on the meaning and materiality of domestic indoor microclimates can contribute to conceptual developments in the field of practice theory that refocus attention on cultural patterns, including prevailing norms and prescriptions regarding indoor temperature and thermal comfort. Drawing on evidence collected during a research-led change initiative that encouraged people to reduce energy use in the home by lowering indoor temperature to 18°C, we deploy the heuristic device of “indoor microclimate as artifact” to show how the manifestation of this new artifact initiated significant changes in everyday practices that revolve around heating. We observe that these changes may also spill over into the public sphere – from home to workplace. By making the microclimate a tangible and visible thing, we describe how people appropriate and appreciate this new object of consumption, what it says about different bodies in diverse and bounded spaces, and what the artifact as a commodity reveals about broader systems of heating and energy provision, and associated actors. Due to the increasing spread of central heating and the growing importance of complex technological devices to monitor and control indoor temperature, heating is no longer a practice in and of itself for many urban dwellers in Europe. However, when people appropriate the indoor microclimate, new heating-related practices emerge that can lead to energy sufficiency. We thus argue that by deliberately “materializing” domestic indoor microclimate as part of a change initiative, more sustainable forms of energy use can be made to matter. </jats:p>
application/pdf
https://sonar.ch/global/documents/261275
eng
info:eu-repo/semantics/altIdentifier/doi/10.1177/1749975520932439
info:eu-repo/semantics/altIdentifier/issn/1749-9755
info:eu-repo/semantics/openAccess
Cultural Sociology. - SAGE Publications. - 2020, vol. 14, no. 4, p. 417-437
Cultural Studies
General Social Sciences
Making “Sustainable Consumption” Matter: The Indoor Microclimate as Contested Cultural Artifact
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261312
2025-10-24T22:01:26Z
Laaser U
Brand H
2014
INTRODUCTION
Since the end of the 1990s, globalization has become a common term, facilitated by the social media of today and the growing public awareness of life-threatening problems common to all people, such as global warming, global security and global divides.
REVIEW
For the main parameters of health like the burden of disease, life expectancy and healthy life expectancy, extreme discrepancies are observed across the world. Infant mortality, malnutrition and high fertility go hand in hand. Civil society, as an indispensable activator of public health development, mainly represented by non-governmental organisations (NGOs), is characterised by a high degree of fragmentation and lack of public accountability. The World Federation of Public Health Associations is used as an example of an NGO with a global mission and fostering regional cooperation as an indispensable intermediate level.The lack of a globally valid terminology of basic public health functions is prohibitive for coordinated global and regional efforts. Attempts to harmonise essential public health functions, services and operations are under way to facilitate communication and mutual understanding.
RECOMMENDATIONS
1) Given the limited effects of the Millennium Development Goal agenda, the Post-2015 Development Goals should focus on integrated regional development. 2) A code of conduct for NGOs should be urgently developed for the health sector, and NGOs should be registered and accredited. 3) The harmonisation of the basic terminology for global public health essentials should be enhanced.
application/pdf
https://sonar.ch/global/documents/261312
eng
info:eu-repo/semantics/altIdentifier/doi/10.3402/gha.v7.23694
info:eu-repo/semantics/altIdentifier/pmid/24560267
info:eu-repo/semantics/openAccess
Global health action. - 2014
civil society
emerging global structures
global health
global public health terminology
health equity
key challenges
Delivery of Health Care
Global Health
Health Status Disparities
Healthy People Programs
Humans
Organizations
Public Health
Global health in the 21st century.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261348
2025-10-24T22:01:22Z
Lefer, Marie-Aude
Cartoni, Bruno
2011
<jats:p>This paper proposes a meaning-based contrastive methodology for the study of prefixation in English, French and Italian which is easily adaptable to other languages and word-formation processes. Our discussion centres on some of the central methodological and theoretical issues involved in contrastive lexical morphology, an area which, to date, has largely remained under-researched. Precise defining criteria for derivative (and prefix) status are presented in order to decide what counts as a derivative (or as a prefix) and what does not. Emphasis is also put on a fined-grained semantic <jats:italic>tertium comparationis</jats:italic> elaborated for the cross-linguistic investigation of lexical morphology and based on a six-tiered semantic categorisation, <jats:italic>viz.</jats:italic> location, evaluation, negation, quantity, modality, and inchoativity, most of which are further divided into finer subcategories. This macro-approach makes it possible to draw important generalisations about the use of word-formation devices across languages.</jats:p>
application/pdf
https://sonar.ch/global/documents/261348
eng
info:eu-repo/semantics/altIdentifier/doi/10.1075/lic.11.1.07lef
info:eu-repo/semantics/altIdentifier/issn/1387-6759
info:eu-repo/semantics/openAccess
Languages in Contrast. - John Benjamins Publishing Company. - 2011, vol. 11, no. 1, p. 87-105
Linguistics and Language
Prefixes in contrast
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261346
2025-10-24T22:01:28Z
Clemente-León, Miguel
Coronado, Eugenio
López-Jordà, Maurici
Waerenborgh, João C.
Desplanches, Cédric
Wang, Hongfeng
Létard, Jean-François
Hauser, Andreas
Tissot, Antoine
2013
https://sonar.ch/global/documents/261346
eng
info:eu-repo/semantics/altIdentifier/doi/10.1021/ja402674x
info:eu-repo/semantics/altIdentifier/issn/0002-7863
Journal of the American Chemical Society. - American Chemical Society (ACS). - 2013, vol. 135, no. 23, p. 8655-8667
Colloid and Surface Chemistry
Biochemistry
General Chemistry
Catalysis
Stimuli Responsive Hybrid Magnets: Tuning the Photoinduced Spin-Crossover in Fe(III) Complexes Inserted into Layered Magnets
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261551
2025-10-24T22:02:27Z
Mirimanoff RO
Ozsahin M
Thariat J
Ozyar E
Schick U
Pehlivan B
Krengli M
Pellanda AF
Vees H
Cai L
Scandolaro L
Belkacemi Y
Villà S
Igdem S
Lutsyk M
Miller RC
2014
Approximately, twenty years ago, the Rare Cancer Network (RCN) was formed in Lausanne, Switzerland, to support the study of rare malignancies. The RCN has grown over the years and now includes 130 investigators from twenty-four nations on six continents. The network held its first international symposium in Nice, France, on March 21-22, 2014. The proceedings of that meeting are presented in two companion papers. This manuscript reviews the history of the growth of the RCN and contains the abstracts of fourteen oral presentations made at the meeting of prior RCN studies. From 1993 to 2014, 74 RCN studies have been initiated, of which 54 were completed, 10 are in progress or under analysis, and 9 were stopped due to poor accrual. Forty-four peer reviewed publications have been written on behalf of the RCN.
application/pdf
https://sonar.ch/global/documents/261551
eng
info:eu-repo/semantics/altIdentifier/doi/10.4081/rt.2014.5462
info:eu-repo/semantics/altIdentifier/pmid/25276325
info:eu-repo/semantics/openAccess
Rare tumors. - 2014
Rare Cancer Network
cancer
carcinoma
diseases
rare
History of the rare cancer network and past research.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261556
2025-10-24T22:02:25Z
Piret J
Schibler M
Pham VD
Hantz S
Giannotti F
Masouridi-Levrat S
Kaiser L
Goyette N
Alain S
Shi R
Boivin G
2019
We report a case of cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient. A previously uncharacterized V787E mutation in UL54 was identified in cerebrospinal fluid but not plasma specimens. For the V787E recombinant virus, the half maximal effective concentrations for ganciclovir, foscarnet, and cidofovir were 8.6-, 3.4- and 2.9-fold higher than for wild-type virus, and the replicative capacity was lower. The introduction of a bulkier and negatively charged glutamate residue at position 787 could destabilize the finger domain of UL54 DNA polymerase. Viral genotyping of cerebrospinal fluid is warranted in subjects with cytomegalovirus encephalitis, owing to the low penetration of antivirals in this compartment.
https://sonar.ch/global/documents/261556
eng
info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiz298
info:eu-repo/semantics/altIdentifier/pmid/31199457
The Journal of infectious diseases. - 2019
Cytomegalovirus
cerebrospinal fluid
compartmentalization
drug resistance
encephalitis
hematopoietic stem cell transplantation
recombinant phenotyping
replicative capacity
three-dimensional modeling
Acyclovir
Antibiotic Prophylaxis
Antiviral Agents
Cerebrospinal Fluid
Cytomegalovirus
Cytomegalovirus Infections
Drug Resistance, Multiple, Viral
Encephalitis, Viral
Female
Graft Rejection
Hematopoietic Stem Cell Transplantation
Humans
Immediate-Early Proteins
Immunosuppression
Middle Aged
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Viral Proteins
Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261537
2025-10-24T22:02:23Z
Favez N
Widmer ED
Frascarolo F
Doan MT
2019
Coparenting between biological parents is a strong predictor of child adjustment. To date, however, little is known about the coparenting dynamics between parent and stepparent in stepfamilies. This study aimed at exploring the links between coparenting in the mother-stepfather dyad and child behavior in stepfamilies compared with the links between mother-father coparenting and child behavior in first-marriage families. Two modes of coparenting were assessed: overt coparenting, that is, coparental behaviors in the presence of the child, and covert coparenting, that is, the way each parent speaks of the other parent to the child. The sample (N = 80) comprised 48 stepfamilies and 32 first-marriage families with a child between 7 and 13 years old. Overt coparenting was assessed through direct observation in the standardized situation of the PicNic Game. Covert coparenting and child behavior were assessed through mother-reported questionnaires. Results showed (a) more covert coparenting behaviors in first-marriage families, (b) no differences in overt coparenting, (c) more child difficulties reported in stepfamilies, (d) less optimal overt coparenting being linked with more difficulties in children in both family structures, and (e) an interaction effect between family structure and coparenting, showing that overt coparenting is linked with child behavior mainly in stepfamilies.
https://sonar.ch/global/documents/261537
eng
info:eu-repo/semantics/altIdentifier/doi/10.1111/famp.12360
info:eu-repo/semantics/altIdentifier/pmid/29626358
Family process. - 2019
Child Adjustment
Coparenting Conflict
Coparenting Support
Mother-Stepfather Dyad
Stepfamilies
adaptación del niño
apoyo en la cocrianza
conflicto en la cocrianza
díada madre-padrastro
familias ensambladas
儿童适应
共同亲职冲突
共同亲职支持
母亲-继父二元组
继亲家庭
Adaptation, Psychological
Adolescent
Child
Child Behavior
Divorce
Family Relations
Female
Humans
Male
Parent-Child Relations
Parenting
Parents
Socioeconomic Factors
Surveys and Questionnaires
Mother-Stepfather Coparenting in Stepfamilies as Predictor of Child Adjustment.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261542
2025-10-24T22:02:24Z
Wagner, Anna Dorothea
Kang, Yoon-Koo
van Dieren, Jolanda
Mauer, Murielle E.
Grabsch, Heike I
Lia, Michela
Atasoy, Ajlan
Cho, Jae Yong
Moehler, Markus H.
Roth, Arnaud
Salto-Tellez, Manuel
Schumacher, Christoph
van Grieken, Nicole C.T.
van Sandick, Johanna W.
Lordick, Florian
https://sonar.ch/global/documents/261542
eng
info:eu-repo/semantics/altIdentifier/doi/10.1200/jco.2016.34.15_suppl.tps4133
info:eu-repo/semantics/altIdentifier/issn/0732-183X
Journal of Clinical Oncology. - American Society of Clinical Oncology (ASCO). - 2016, vol. 34, no. 15_suppl, p. TPS4133-TPS4133
Cancer Research
Oncology
EORTC-1203: Integration of trastuzumab (T), with or without pertuzumab (P), into perioperative chemotherapy (CT) of HER-2 positive stomach cancer—INNOVATION trial.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261636
2025-10-24T22:02:33Z
Polcari, A.
Pace, S.
Dhalle, M.
Huang, Y.
Witz, G.
Marti, F.
Flükiger, R.
2012
<jats:p> The influence of the geometrical parameters on the behaviour of the AC losses in multifilamentary Ag-BSCCO(2223) tapes is being more and more evident. Recently, the effects of configurational parameters like the ratio between the overall width and thickness of tapes without barriers as well as their precise arrangements has been put in evidence either theoretically or experimentally. With the goal to go deeper into the comprehension of this relation, we characterized a serie of multifilamentary tapes with gradually different filament arrangements. They were measured in a self-field AC transport system at different frequencies, for current values up to the critical state. The results so obtained are discussed taking into account of some theoretical models. </jats:p>
https://sonar.ch/global/documents/261636
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/s0217979299001387
info:eu-repo/semantics/altIdentifier/issn/0217-9792
International Journal of Modern Physics B. - World Scientific Pub Co Pte Lt. - 1999, vol. 13, no. 09n10, p. 1327-1332
Self-Field AC Losses on Ag-BSCCO(2223) Multifilamentary Tapes with Different Filament Arrangements
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261526
2025-10-24T22:02:22Z
Arnoux G
Pusztaszeri M
2018
"Noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) is a recent reclassification of the encapsulated follicular variant of papillary thyroid carcinoma, which is supposed to reflect its indolent clinical behavior and to prevent overtreatment of patients with this neoplasm. The diagnosis of NIFTP can only be made histologically on the surgical specimen according to specific inclusion and exclusion criteria, which requires the examination of the whole nodule and its capsule. Spindle cell proliferations, especially of follicular cell origin, arising within thyroid follicular neoplasms are very rare and may cause diagnostic difficulties. Few reports described spindle cell proliferations arising in follicular thyroid adenoma and papillary thyroid carcinoma. To the best of our knowledge, only one case has been reported in NIFTP so far. In this article, we report a unique case of NIFTP associated with a spindle cell proliferation that was characterized immunohistochemically. Specific issues related to this case are discussed.
https://sonar.ch/global/documents/261526
eng
info:eu-repo/semantics/altIdentifier/doi/10.1177/1066896917741548
info:eu-repo/semantics/altIdentifier/pmid/29212393
International journal of surgical pathology. - 2018
NIFTP
follicular adenoma
metaplasia
papillary carcinoma
spindle cell
thyroid
Adenocarcinoma, Follicular
Adult
Carcinoma, Papillary
Female
Humans
Metaplasia
Thyroid Cancer, Papillary
Thyroid Neoplasms
"Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features" With Focal Spindle Cell Metaplasia.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261579
2025-10-24T22:02:28Z
Keizer I
Eytan A
2005
BACKGROUND
Smoking and exposure to smoke are important concerns, especially in psychiatric in-patient services.
AIMS
Our aims were to study variations in smoking after hospitalization for psychiatric in-patients, and to evaluate smoking-related concerns and prevalence for both patients and health-care staff.
METHODS
A similar survey was mailed to staff members and proposed individually to all recently admitted patients; participation rates were 39% and 79% respectively.
RESULTS
Three days after admission, 4/10 patients had increased and 3/10 had decreased their daily tobacco use. Univariate analysis of variance showed nicotine dependence scores to be associated with variations in consumption (p = .005): whereas 74% of heavy smokers decreased cigarette consumption, 80% of light and 57% of moderate smokers increased their consumption. The prevalence of current smoking was twice as high in patients (72%) as compared to health-care professionals (31%). Patients were also more nicotine dependent (Heaviness of Smoking Index (HSI) = 3.97/vs. 1.81), and half of the patients were heavy smokers (> 20 cigarettes/day), as opposed to only 6.3% of the staff.
CONCLUSIONS
Smoking prevalence and daily tobacco consumption are very high in psychiatric patients. After hospitalization, light and moderate smokers increased whereas heavy smokers decreased smoking.
https://sonar.ch/global/documents/261579
eng
info:eu-repo/semantics/altIdentifier/doi/10.1177/0020764005057377
info:eu-repo/semantics/altIdentifier/pmid/16400907
The International journal of social psychiatry. - 2005
Adult
Female
Health Surveys
Hospitals, University
Humans
Inpatients
Male
Medical Staff, Hospital
Prevalence
Psychiatric Department, Hospital
Smoking
Surveys and Questionnaires
Tobacco Smoke Pollution
Variations in smoking during hospitalization in psychiatric in-patient units and smoking prevalence in patients and health-care staff.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261521
2025-10-24T22:02:22Z
Debarbieux, Bernard
2017
https://sonar.ch/global/documents/261521
eng
info:eu-repo/semantics/altIdentifier/doi/10.1080/1755182x.2017.1292658
info:eu-repo/semantics/altIdentifier/issn/1755-182X
Journal of Tourism History. - Informa UK Limited. - 2016, vol. 8, no. 3, p. 323-325
Tourism, Leisure and Hospitality Management
Geography, Planning and Development
Cultural Studies
History
Transportation
Apostles of the Alps: mountaineering and nation building in Germany and Austria, 1860–1939
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261522
2025-10-24T22:02:22Z
Macchione, Mariano
Chuard, Nicolas
Sakai, Naomi
Matile, Stefan
2017
https://sonar.ch/global/documents/261522
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/cplu.201700265
info:eu-repo/semantics/altIdentifier/issn/2192-6506
ChemPlusChem. - Wiley. - 2017, vol. 82, no. 7, p. 941-941
Inside Cover: Planarizable Push-Pull Probes: Overtwisted Flipper Mechanophores (ChemPlusChem 7/2017)
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261575
2025-10-24T22:02:41Z
Darabos, Christian
Giacobini, Mario
Tomassini, Marco
<jats:p>Random Boolean Networks (RBN) have been introduced by Kauffman more than thirty years ago as a highly simplified model of genetic regulatory networks. This extremely simple and abstract model has been studied in detail and has been shown capable of extremely interesting dynamical behavior. First of all, as some parameters are varied such as the network’s connectivity, or the probability of expressing a gene, the RBN can go through a phase transition, going from an ordered regime to a chaotic one. Kauffman’s suggestion is that cell types correspond to attractors in the RBN phase space, and only those attractors that are short and stable under perturbations will be of biological interest. Thus, according to Kauffman, RBN lying at the edge between the ordered phase and the chaotic phase can be seen as abstract models of genetic regulatory networks. The original view of Kauffman, namely that these models may be useful for understanding real-life cell regulatory networks, is still valid, provided that the model is updated to take into account present knowledge about the topology of real gene regulatory networks, and the timing of events, without loosing its attractive simplicity. According to present data, many biological networks, including genetic regulatory networks, seem, in fact, to be of the scale-free type. From the point of view of the timing of events, standard RBN update their state synchronously. This assumption is open to discussion when dealing with biologically plausible networks. In particular, for genetic regulatory networks, this is certainly not the case: genes seem to be expressed in different parts of the network at different times, according to a strict sequence, which depends on the particular network under study. The expression of a gene depends on several transcription factors, the synthesis of which appear to be neither fully synchronous nor instantaneous. Therefore, we have recently proposed a new, more biologically plausible model. It assumes a scale-free topology of the networks and we define a suitable semi-synchronous dynamics that better captures the presence of an activation sequence of genes linked to the topological properties of the network. By simulating statistical ensembles of networks, we discuss the attractors of the dynamics, showing that they are compatible with theoretical biological network models. Moreover, the model demonstrates interesting scaling abilities as the size of the networks is increased.</jats:p>
application/pdf
https://sonar.ch/global/documents/261575
eng
info:eu-repo/semantics/altIdentifier/doi/10.4018/978-1-60566-685-3.ch018
info:eu-repo/semantics/openAccess
Handbook of Research on Computational Methodologies in Gene Regulatory Networks. - IGI Global. - 2010, p. 429-449
Generalized Boolean Networks
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261607
2025-10-24T22:02:46Z
Eisner, Léïla
Clémence, Alain
Roberts, Caroline
Joost, Stéphane
Theler, Jean-Marc
2018
<jats:p> A key challenge in the design of effective survey questionnaires is to write questions that respondents can understand consistently. Recommendations in the questionnaire design literature propose the use of respondents’ own terminology to facilitate comprehension and the response process. In this article, we propose an innovative questionnaire development method to construct items using respondents’ own terminology. On the basis of statistical analyses of answers to an open-ended question asked in a survey measuring attitudes to biodiversity, we first identified the words that respondents associate most frequently with the concept of biodiversity. We then designed new attitude measures composed of the words identified as being central to representations about biodiversity. These items were tested in another survey using a different sample. The results show that the attitude items designed on the basis of a social representation method satisfied validity and reliability quality criteria. </jats:p>
application/pdf
https://sonar.ch/global/documents/261607
eng
info:eu-repo/semantics/altIdentifier/doi/10.1177/1525822x18797280
info:eu-repo/semantics/altIdentifier/issn/1525-822X
info:eu-repo/semantics/openAccess
Field Methods. - SAGE Publications. - 2018, vol. 31, no. 1, p. 56-75
Anthropology
Developing Attitude Measures Based on Respondents’ Representations of Unfamiliar Objects: An Application to Attitudes toward Biodiversity
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261547
2025-10-24T22:02:38Z
Taylor, A. M.
2011
application/pdf
https://sonar.ch/global/documents/261547
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789814329033_0070
info:eu-repo/semantics/openAccess
Cosmic Rays for Particle and Astroparticle Physics. - WORLD SCIENTIFIC. - 2011
THE CR CONNECTION: UHE PRIMARIES AND SECONDARIES FROM UHECR SOURCES
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261613
2025-10-24T22:02:47Z
de Chambrier, Anne-Françoise
Thevenot, Catherine
Barrouillet, Pierre
Zesiger, Pascal
2018
https://sonar.ch/global/documents/261613
eng
info:eu-repo/semantics/altIdentifier/doi/10.1080/20445911.2018.1502190
info:eu-repo/semantics/altIdentifier/issn/2044-5911
Journal of Cognitive Psychology. - Informa UK Limited. - 2018, vol. 30, no. 5-6, p. 503-510
Experimental and Cognitive Psychology
Arts and Humanities (miscellaneous)
Frequency of finger looking during finger counting is related to children's working memory capacities
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260810
2025-10-24T21:58:41Z
Serra EG
Schwerd T
Moutsianas L
Cavounidis A
Fachal L
Pandey S
Kammermeier J
Croft NM
Posovszky C
Rodrigues A
Russell RK
Barakat F
Auth MKH
Heuschkel R
Zilbauer M
Fyderek K
Braegger C
Travis SP
Satsangi J
Parkes M
Thapar N
Ferry H
Matte JC
Gilmour KC
Wedrychowicz A
Sullivan P
Moore C
Sambrook J
Ouwehand W
Roberts D
Danesh J
Baeumler TA
Fulga TA
Karaminejadranjbar M
Ahmed A
Wilson R
Barrett JC
Elkadri A
Griffiths AM
Snapper SB
Shah N
Muise AM
Wilson DC
Uhlig HH
Anderson CA
2020
Very-early-onset inflammatory bowel disease (VEO-IBD) is a heterogeneous phenotype associated with a spectrum of rare Mendelian disorders. Here, we perform whole-exome-sequencing and genome-wide genotyping in 145 patients (median age-at-diagnosis of 3.5 years), in whom no Mendelian disorders were clinically suspected. In five patients we detect a primary immunodeficiency or enteropathy, with clinical consequences (XIAP, CYBA, SH2D1A, PCSK1). We also present a case study of a VEO-IBD patient with a mosaic de novo, pathogenic allele in CYBB. The mutation is present in ~70% of phagocytes and sufficient to result in defective bacterial handling but not life-threatening infections. Finally, we show that VEO-IBD patients have, on average, higher IBD polygenic risk scores than population controls (99 patients and 18,780 controls; P < 4 × 10-10), and replicate this finding in an independent cohort of VEO-IBD cases and controls (117 patients and 2,603 controls; P < 5 × 10-10). This discovery indicates that a polygenic component operates in VEO-IBD pathogenesis.
application/pdf
https://sonar.ch/global/documents/260810
eng
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-019-14275-y
info:eu-repo/semantics/altIdentifier/pmid/32081864
info:eu-repo/semantics/openAccess
Nature communications. - 2020
Adult
Age of Onset
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Female
Genes, Recessive
Genetic Predisposition to Disease
Genetic Variation
Humans
Infant
Infant, Newborn
Inflammatory Bowel Diseases
Loss of Function Mutation
Male
Mosaicism
Multifactorial Inheritance
Mutation
NADPH Oxidase 2
Pedigree
Primary Immunodeficiency Diseases
Risk Factors
Whole Exome Sequencing
Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260685
2025-10-24T21:58:32Z
Van den Berge K
Perraudeau F
Soneson C
Love MI
Risso D
Vert JP
Robinson MD
Dudoit S
Clement L
2018
Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero inflation. Recent evaluations, however, have shown that dedicated scRNA-seq tools provide no advantage compared to traditional bulk RNA-seq tools. We introduce a weighting strategy, based on a zero-inflated negative binomial model, that identifies excess zero counts and generates gene- and cell-specific weights to unlock bulk RNA-seq DE pipelines for zero-inflated data, boosting performance for scRNA-seq.
application/pdf
https://sonar.ch/global/documents/260685
eng
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13059-018-1406-4
info:eu-repo/semantics/altIdentifier/pmid/29478411
info:eu-repo/semantics/openAccess
Genome biology. - 2018
Differential expression
Single-cell RNA sequencing
Weights
Zero-inflated negative binomial
Gene Expression Profiling
Sequence Analysis, RNA
Single-Cell Analysis
Software
Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260745
2025-10-24T21:58:35Z
Meier F
Milek A
Rauch-Anderegg V
Benz-Fragnière C
Nieuwenboom JW
Schmid H
Halford WK
Bodenmann G
2020
The transition to parenthood (TTP) is a stressful life event for most couples. Therefore, the way both partners jointly cope with stress (i.e., dyadic coping) is important for the prevention of individual adjustment problems (e.g., depression). For dyadic coping to be effective in reducing depressive symptoms, efforts of both partners should be equal. However, many couples experience a decrease of equity in task division within the domestic sphere across the TTP. The current study investigates the equity of a specific skill within the 'relationship sphere', because similarly to a decreased equity in household and childcare, a decreased equity of dyadic coping is likely to be associated with poorer individual adjustment. We collected longitudinal self-report data on dyadic coping and depressive symptoms from 104 mixed-gender first-time parents (n = 208 individuals) from pregnancy until 40 weeks postpartum. We created an equity score for men and women that measured their perceived difference between received and provided dyadic coping. On average, women reported providing more and receiving less dyadic coping than men. While both genders agreed on this distribution, men did perceive a higher equity of dyadic coping than women. Furthermore, the decrease of equity perceived by women across TTP was not visible in men. In line with our assumptions based on the equity theory, perceived equity of dyadic coping was associated with depressive symptoms in a curvilinear manner: Decreases in women's perceived equity in either direction (over- or underbenefit) were associated with more depressive symptoms in women and their male partners. This association was found above and beyond the beneficial effect of dyadic coping itself. This implies that not only how well partners support each other in times of stress, but also how equal both partners' efforts are, is important for their individual adjustment across TTP.
application/pdf
https://sonar.ch/global/documents/260745
eng
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0227342
info:eu-repo/semantics/altIdentifier/pmid/32074100
info:eu-repo/semantics/openAccess
PloS one. - 2020
Adaptation, Psychological
Adult
Depression
Family Characteristics
Female
Humans
Interpersonal Relations
Male
Middle Aged
Parents
Stress, Psychological
Fair enough? Decreased equity of dyadic coping across the transition to parenthood associated with depression of first-time parents.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260670
2025-10-24T21:58:28Z
Bezan A
Posch F
Ploner F
Bauernhofer T
Pichler M
Szkandera J
Hutterer GC
Pummer K
Gary T
Samonigg H
Beyer J
Winder T
Hermanns T
Fankhauser CD
Gerger A
Stotz M
2017
BACKGROUND
Patients with testicular germ cell tumors (TGCT) have an increased risk for venous thromboembolism (VTE). We identified risk factors for VTE in this patient cohort and developed a clinical risk model.
METHODS
In this retrospective cohort study at the Medical University of Graz we included 657 consecutive TGCT patients across all clinical stages. A predictive model for VTE was developed and externally validated in 349 TGCT patients treated at the University Hospital Zurich.
RESULTS
Venous thromboembolic events occurred in 34 (5.2%) patients in the Graz cohort. In univariable competing risk analysis, higher clinical stage (cS) and a retroperitoneal lymphadenopathy (RPLN) were the strongest predictors of VTE (p<0.0001). As the presence of a RPLN with more than 5cm in greatest dimension without coexisting visceral metastases is classified as cS IIC, we constructed an empirical VTE risk model with the following four categories (12-month-cumulative incidence): cS IA-B 8/463 patients (1.7%), cS IS-IIB 5/86 patients (5.9%), cS IIC 3/21 patients (14.3%) and cS IIIA-C 15/70 patients (21.4%). This risk model was externally validated in the Zurich cohort (12-month-cumulative incidence): cS IA-B (0.5%), cS IS-IIB (6.0%), cS IIC (11.1%) and cS IIIA-C (19.1%). Our model had a significantly higher discriminatory performance than a previously published classifier (RPLN-VTE-risk-classifier) which is based on the size of RPLN alone (AUC-ROC: 0.75 vs. 0.63, p = 0.007).
CONCLUSIONS
According to our risk stratification, TGCT patients with cS IIC and cS III disease have a very high risk of VTE and may benefit from primary thromboprophylaxis for the duration of chemotherapy.
application/pdf
https://sonar.ch/global/documents/260670
eng
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0176283
info:eu-repo/semantics/altIdentifier/pmid/28430804
info:eu-repo/semantics/openAccess
PloS one. - 2017
Adult
Humans
Male
Neoplasms, Germ Cell and Embryonal
Retrospective Studies
Risk Factors
Testicular Neoplasms
Venous Thromboembolism
Risk stratification for venous thromboembolism in patients with testicular germ cell tumors.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260775
2025-10-24T21:58:39Z
Hrusak O
Kalina T
Wolf J
Balduzzi A
Provenzi M
Rizzari C
Rives S
Del Pozo Carlavilla M
Alonso MEV
Domínguez-Pinilla N
Bourquin JP
Schmiegelow K
Attarbaschi A
Grillner P
Mellgren K
van der Werff Ten Bosch J
Pieters R
Brozou T
Borkhardt A
Escherich G
Lauten M
Stanulla M
Smith O
Yeoh AEJ
Elitzur S
Vora A
Li CK
Ariffin H
Kolenova A
Dallapozza L
Farah R
Lazic J
Manabe A
Styczynski J
Kovacs G
Ottoffy G
Felice MS
Buldini B
Conter V
Stary J
Schrappe M
2020
INTRODUCTION
Since the beginning of COVID-19 pandemic, it is known that the severe course of the disease occurs mostly among the elderly, whereas it is rare among children and young adults. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. A weaker immunity of the elderly has been proposed as a possible explanation of this uneven age distribution. Thus, there is concern that children treated for cancer may allso be at risk for an unfavourable course of infection. Along the same line, anecdotal information from Wuhan, China, mentioned a severe course of COVID-19 in a child treated for leukaemia.
AIM AND METHODS
We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. Respondents were asked by email to fill in a short Web-based survey.
RESULTS
We received reports from 25 countries, where approximately 10,000 patients at risk are followed up. At the time of the survey, more than 200 of these children were tested, nine of whom were positive for COVID-19. Eight of the nine cases had asymptomatic to mild disease, and one was just diagnosed with COVID-19. We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19.
CONCLUSION
Thus, even children receiving anticancer chemotherapy may have a mild or asymptomatic course of COVID-19. While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment.
application/pdf
https://sonar.ch/global/documents/260775
eng
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejca.2020.03.021
info:eu-repo/semantics/altIdentifier/pmid/32305831
info:eu-repo/semantics/openAccess
European journal of cancer (Oxford, England : 1990). - 2020
Anticancer chemotherapy
COVID-19
Children
Immunosuppression
Adolescent
Antineoplastic Agents
Betacoronavirus
Child
Coronavirus Infections
Female
Humans
Male
Neoplasms
Pandemics
Pneumonia, Viral
Surveys and Questionnaires
Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260742
2025-10-24T21:58:35Z
Khalsa SS
Adolphs R
Cameron OG
Critchley HD
Davenport PW
Feinstein JS
Feusner JD
Garfinkel SN
Lane RD
Mehling WE
Meuret AE
Nemeroff CB
Oppenheimer S
Petzschner FH
Pollatos O
Rhudy JL
Schramm LP
Simmons WK
Stein MB
Stephan KE
Van den Bergh O
Van Diest I
von Leupoldt A
Paulus MP
2018
Interoception refers to the process by which the nervous system senses, interprets, and integrates signals originating from within the body, providing a moment-by-moment mapping of the body's internal landscape across conscious and unconscious levels. Interoceptive signaling has been considered a component process of reflexes, urges, feelings, drives, adaptive responses, and cognitive and emotional experiences, highlighting its contributions to the maintenance of homeostatic functioning, body regulation, and survival. Dysfunction of interoception is increasingly recognized as an important component of different mental health conditions, including anxiety disorders, mood disorders, eating disorders, addictive disorders, and somatic symptom disorders. However, a number of conceptual and methodological challenges have made it difficult for interoceptive constructs to be broadly applied in mental health research and treatment settings. In November 2016, the Laureate Institute for Brain Research organized the first Interoception Summit, a gathering of interoception experts from around the world, with the goal of accelerating progress in understanding the role of interoception in mental health. The discussions at the meeting were organized around four themes: interoceptive assessment, interoceptive integration, interoceptive psychopathology, and the generation of a roadmap that could serve as a guide for future endeavors. This review article presents an overview of the emerging consensus generated by the meeting.
https://sonar.ch/global/documents/260742
eng
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bpsc.2017.12.004
info:eu-repo/semantics/altIdentifier/pmid/29884281
Biological psychiatry. Cognitive neuroscience and neuroimaging. - 2018
Biomarker
Computational psychiatry
Interoception
Mental health
Research Domain Criteria
Treatment
Awareness
Brain
Cognition
Emotions
Humans
Interoception
Mental Health
Interoception and Mental Health: A Roadmap.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260830
2025-10-24T21:59:14Z
Bach DR
Hoffmann M
Finke C
Hurlemann R
Ploner CJ
2019
Anxiety comprises a suite of behaviors to deal with potential threat and is often modeled in approach-avoidance conflict tasks. Collectively, these tests constitute a predominant preclinical model of anxiety disorder. A body of evidence suggests that both ventral hippocampus and amygdala lesions impair anxiety-like behavior, but the relative contribution of these two structures is unclear. A possible reason is that approach-avoidance conflict tasks involve a series of decisions and actions, which may be controlled by distinct neural mechanisms that are difficult to disentangle from behavioral readouts. Here, we capitalize on a human approach-avoidance conflict test, implemented as computer game, that separately measures several action components. We investigate three patients of both sexes with unspecific unilateral medial temporal lobe (MTL) damage, one male with selective bilateral hippocampal (HC), and one female with selective bilateral amygdala lesions, and compare them to matched controls. MTL and selective HC lesions, but not selective amygdala lesions, increased approach decision when possible loss was high. In contrast, MTL and selective amygdala lesions, but not selective HC lesions, increased return latency. Additionally, selective HC and selective amygdala lesions reduced approach latency. In a task targeted at revealing subjective assumptions about the structure of the computer game, MTL and selective HC lesions impacted on reaction time generation but not on the subjective task structure. We conclude that deciding to approach reward under threat relies on hippocampus but not amygdala, whereas vigor of returning to safety depends on amygdala but not on hippocampus.SIGNIFICANCE STATEMENT Approach-avoidance conflict tests are widely investigated in rodents, and increasingly in humans, to understand the neural basis of anxiety-like behavior. However, the contribution of the most relevant brain regions, ventral hippocampus and amygdala, is incompletely understood. We use a human computerized test that separates different action components and find that hippocampus, but not amygdala, lesions impair approach decisions, whereas amygdala, but not hippocampus, lesions impair the vigor of return to safety.
application/pdf
https://sonar.ch/global/documents/260830
eng
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.0412-19.2019
info:eu-repo/semantics/altIdentifier/pmid/31501296
info:eu-repo/semantics/openAccess
The Journal of neuroscience : the official journal of the Society for Neuroscience. - 2019
anxiety-like behavior
approach decision
approach–avoidance conflict
clinical lesion models
double-dissociation
escape vigor
Adult
Amygdala
Anxiety
Avoidance Learning
Conditioning, Operant
Conflict, Psychological
Decision Making
Female
Hippocampus
Humans
Male
Middle Aged
Neuropsychological Tests
Reward
Disentangling Hippocampal and Amygdala Contribution to Human Anxiety-Like Behavior.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260852
2025-10-24T21:59:23Z
Kündig P
Giesen C
Jackson H
Bodenmiller B
Papassotirolopus B
Freiberger SN
Aquino C
Opitz L
Varga Z
2018
BACKGROUND
Intra-tumoral heterogeneity has been recently addressed in different types of cancer, including breast cancer. A concept describing the origin of intra-tumoral heterogeneity is the cancer stem-cell hypothesis, proposing the existence of cancer stem cells that can self-renew limitlessly and therefore lead to tumor progression. Clonal evolution in accumulated single cell genomic alterations is a further possible explanation in carcinogenesis. In this study, we addressed the question whether intra-tumoral heterogeneity can be reliably detected in tissue-micro-arrays in breast cancer by comparing expression levels of conventional predictive/prognostic tumor markers, tumor progression markers and stem cell markers between central and peripheral tumor areas.
METHODS
We analyzed immunohistochemical expression and/or gene amplification status of conventional prognostic tumor markers (ER, PR, HER2, CK5/6), tumor progression markers (PTEN, PIK3CA, p53, Ki-67) and stem cell markers (mTOR, SOX2, SOX9, SOX10, SLUG, CD44, CD24, TWIST) in 372 tissue-micro-array samples from 72 breast cancer patients. Expression levels were compared between central and peripheral tumor tissue areas and were correlated to histopathological grading. 15 selected cases additionally underwent RNA sequencing for transcriptome analysis.
RESULTS
No significant difference in any of the analyzed between central and peripheral tumor areas was seen with any of the analyzed methods/or results that showed difference. Except mTOR, PIK3CA and SOX9 (nuclear) protein expression, all markers correlated significantly (p < 0.05) with histopathological grading both in central and peripheral areas.
CONCLUSION
Our results suggest that intra-tumoral heterogeneity of stem-cell and tumor-progression markers cannot be reliably addressed in tissue-micro-array samples in breast cancer. However, most markers correlated strongly with histopathological grading confirming prognostic information as expression profiles were independent on the site of the biopsy was taken.
application/pdf
https://sonar.ch/global/documents/260852
eng
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12967-018-1495-6
info:eu-repo/semantics/altIdentifier/pmid/29739401
info:eu-repo/semantics/openAccess
Journal of translational medicine. - 2018
Breast cancer
Intratumoral heterogeneity
Stem cells
Tissue micro array
Tumor progression
Biomarkers, Tumor
Breast Neoplasms
Disease Progression
Female
Humans
Neoplasm Grading
Neoplastic Stem Cells
Prognosis
Tissue Array Analysis
Transcriptome
Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260847
2025-10-24T21:59:22Z
Wu L
Blum W
Zhu CQ
Yun Z
Pecze L
Kohno M
Chan ML
Zhao Y
Felley-Bosco E
Schwaller B
de Perrot M
2018
BACKGROUND
Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target therapies against MSC to improve the efficacy of treatment in malignant mesothelioma.
METHODS
Murine mesothelioma AB12 and RN5 cells were used to compare tumorigenicity in mice. The expression of CSC-associated genes was evaluated by quantitative real-time PCR in both cell lines treated with chemo-radiation. Stemness properties of MSC-enriched RN5-EOS-Puro2 cells were characterized with flow cytometry and immunostaining. A MSC-specific gene profile was screened by microarray assay and confirmed thereafter. Gene Ontology analysis of the selected genes was performed by GOMiner.
RESULTS
Tumor growth delay of murine mesothelioma AB12 cells was achieved after each cycle of cisplatin treatment, however, tumors grew back rapidly due to cancer cell repopulation between courses of chemotherapy. Strikingly, a 10-times lower number of irradiated cells in both cell lines led to a similar tumor incidence and growth rate as with untreated cells. The expression of CSC-associated genes such as CD24, CD133, CD90 and uPAR was dramatically up-regulated, while others did not change significantly after chemoradiation. Highly enriched MSC after selection with puromycin displayed an increasing GFP-positive population and showed typical properties of stemness. Comparatively, the proportion of MSC significantly increased after RN5-EOS parental cells were treated with either chemotherapy, γ-ray radiation, or a combination of the two, while MSC showed more resistance to the above treatments. A group of identified genes are most likely MSC-specific, and major pathways related to regulation of cell growth or apoptosis are involved. Upregulation of the gene transcripts Tnfsf18, Serpinb9b, Ly6a, and Nppb were confirmed.
CONCLUSION
Putative MSC possess the property of stemness showing more resistance to chemoradiation, suggesting that MSC may play critical roles in cancer cell repopulation. Further identification of selected genes may be used to design novel target therapies against MSC, so as to eliminate cancer cell repopulation in mesothelioma.
https://sonar.ch/global/documents/260847
eng
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12885-018-4354-1
info:eu-repo/semantics/altIdentifier/pmid/29699510
BMC cancer. - 2018
Cancer cell repopulation
Chemoradiation
Mesothelioma stem cell (MSC)
Microarray
RN5-EOS-Puro2 cells
Animals
Cell Line, Tumor
Cell Survival
Chemoradiotherapy
Computational Biology
Disease Models, Animal
Drug Resistance, Neoplasm
Flow Cytometry
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Mesothelioma
Mice
Neoplastic Stem Cells
Radiation Tolerance
Xenograft Model Antitumor Assays
Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260874
2025-10-24T21:59:25Z
Völger M
Steinhausen HC
Reitzle M
1993
Thirty-two child psychiatric patients with minor neurological dysfunction (MND) were followed-up after a mean interval of 5.3 years. Six clusters were analyzed that measured posture and muscle tonus, reflexes, coordination and balance, fine manipulative ability, choreiform dyskinesia, and associated movements. In the majority of cases, remission occurred for posture and muscle tonus, and choreiform dyskinesia and reflexes. Problems with fine manipulative ability and associated movements, however, persisted in most cases. Change in the total MND-abnormality score was also analyzed. Elevated scores and greater age at the initial assessment, and longer intervals between the initial assessment and follow-up were associated with greater improvement, indicating that biological maturation is an important factor in symptom remission. Slow background activity was the predominant EEG-pattern that tended to persist rather than to remit over time. A wide spectrum of psychiatric diagnoses was recorded on both occasions. In general, the tendency for remission of psychiatric disorders was stronger than that of persistence and new manifestation. In addition, with regard to behavioural abnormalities, the total score and subscore for emotional disorders diminished over time.
https://sonar.ch/global/documents/260874
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/BF02125568
info:eu-repo/semantics/altIdentifier/pmid/29871429
European child & adolescent psychiatry. - 1993
Biological Maturation
Clinic Attender
Muscle Tonus
Slow Background
Symptom Remission
A follow-up study of child psychiatric clinic attenders with minor neurological dysfunction.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261056
2025-10-24T21:59:39Z
Shalaby T
von Bueren AO
Hürlimann ML
Fiaschetti G
Castelletti D
Masayuki T
Nagasawa K
Arcaro A
Jelesarov I
Shin-ya K
Grotzer M
2010
We investigated here the effects of S2T1-6OTD, a novel telomestatin derivative that is synthesized to target G-quadruplex-forming DNA sequences, on a representative panel of human medulloblastoma (MB) and atypical teratoid/rhabdoid (AT/RT) childhood brain cancer cell lines. S2T1-6OTD proved to be a potent c-Myc inhibitor through its high-affinity physical interaction with the G-quadruplex structure in the c-Myc promoter. Treatment with S2T1-6OTD reduced the mRNA and protein expressions of c-Myc and hTERT, which is transcriptionally regulated by c-Myc, and decreased the activities of both genes. In remarkable contrast to control cells, short-term (72-hour) treatment with S2T1-6OTD resulted in a dose- and time-dependent antiproliferative effect in all MB and AT/RT brain tumor cell lines tested (IC(50), 0.25-0.39 micromol/L). Under conditions where inhibition of both proliferation and c-Myc activity was observed, S2T1-6OTD treatment decreased the protein expression of the cell cycle activator cyclin-dependent kinase 2 and induced cell cycle arrest. Long-term treatment (5 weeks) with nontoxic concentrations of S2T1-6OTD resulted in a time-dependent (mainly c-Myc-dependent) telomere shortening. This was accompanied by cell growth arrest starting on day 28 followed by cell senescence and induction of apoptosis on day 35 in all of the five cell lines investigated. On in vivo animal testing, S2T1-6OTD may well represent a novel therapeutic strategy for childhood brain tumors.
application/pdf
https://sonar.ch/global/documents/261056
eng
info:eu-repo/semantics/altIdentifier/doi/10.1158/1535-7163.MCT-09-0586
info:eu-repo/semantics/altIdentifier/pmid/20053783
info:eu-repo/semantics/openAccess
Molecular cancer therapeutics. - 2010
Apoptosis
Base Sequence
Cell Cycle
Cell Line, Tumor
Cell Proliferation
Cell Survival
Cyclin-Dependent Kinase 2
Dose-Response Relationship, Drug
Down-Regulation
Drug Screening Assays, Antitumor
G-Quadruplexes
Humans
Medulloblastoma
Oxazoles
Promoter Regions, Genetic
Protein Binding
Proto-Oncogene Proteins c-myc
RNA, Messenger
Rhabdoid Tumor
Telomerase
Teratoma
Time Factors
Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260856
2025-10-24T21:59:33Z
Siebenhüner A
De Dosso S
Meisel A
Wagner AD
Borner M
2020
BACKGROUND
Metastatic colorectal carcinoma (mCRC) is one of the most prevalent types of cancer worldwide. After tumor progression with first- and second-line treatment, trifluridine (FTD) and tipiracil (TPI) has been shown to be a treatment option.
SUMMARY
Data from a pivotal phase 3 trial (RECOURSE) and an ongoing phase 3b trial (PRECONNECT) have shown that, in mCRC patients who experienced disease progression after 2 lines of standard therapy, treatment with FTD/TPI is safe and efficacious. Other third-line options include regorafenib, rechallenge with previous treatment lines or personalized approaches based on comprehensive molecular profiling. Randomized trials or sequential studies aiming for the right treatment sequence or predefined subtypes for FTD/TPI or regorafenib as well for rechallenge are missing. However, FTD/TPI as well as regorafenib are recommended by the current ESMO, German S3, and National Comprehensive Cancer Network (NCCN) guidelines in the same situation, thus offering physicians a number of alternatives for the treatment of mCRC patients after the second progression. Key Message: This narrative review summarizes published data and their impact for FTD/TPI as well for regorafenib and rechallenge chemotherapy in clinical practice settings of refractory situations of colorectal cancer.
application/pdf
https://sonar.ch/global/documents/260856
eng
info:eu-repo/semantics/altIdentifier/doi/10.1159/000506080
info:eu-repo/semantics/altIdentifier/pmid/32146471
info:eu-repo/semantics/openAccess
Oncology research and treatment. - 2020
Lonsurf
Rechallenge
Refractory colorectal cancer
Regorafenib
Second progression
Tas-102
Trifluridine-tipiracil
Antineoplastic Combined Chemotherapy Protocols
Clinical Trials, Phase III as Topic
Colorectal Neoplasms
Disease Progression
Drug Combinations
Humans
Neoplasm Metastasis
Phenylurea Compounds
Pyridines
Pyrrolidines
Survival Rate
Switzerland
Treatment Outcome
Trifluridine
Uracil
Metastatic Colorectal Carcinoma after Second Progression and the Role of Trifluridine-Tipiracil (TAS-102) in Switzerland.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:260911
2025-10-24T21:59:36Z
Babor F
Peters C
Manser AR
Glogova E
Sauer M
Pötschger U
Ahlmann M
Cario G
Feuchtinger T
Gruhn B
Güngör T
Horn PA
Kremens B
Lang P
Mezger M
Müller I
Mytilineos J
Oevermann L
Pichler H
Scherenschlich N
Schuster FR
Siepermann M
Stachel D
Strahm B
Wössmann W
Escherich G
Zimmermann M
Schrappe M
Borkhardt A
Eckert C
Bader P
Uhrberg M
Meisel R
2019
Although allogeneic hematopoietic stem-cell transplantation (HSCT) provides high cure rates for children with high-risk acute lymphoblastic leukaemia (ALL), relapses remain the main cause of treatment failure. Whereas donor killer cell immunoglobulin-like receptor (KIR) genotype was shown to impact on relapse incidence in adult myeloid leukaemia similar studies in paediatric ALL are largely missing. Effect of donor KIR genotype on transplant outcome was evaluated in 317 children receiving a first myeloablative HSCT from an HLA-matched unrelated donor or sibling within the prospective ALL-SCT-BFM-2003 trial. Analysis of donor KIR gene polymorphism revealed that centromeric presence and telomeric absence of KIR B haplotypes was associated with reduced relapse risk. A centromeric/telomeric KIR score (ct-KIR score) integrating these observations correlated with relapse risk (hazard ratio (HR) 0.58; P = 0.002) while it had no impact on graft-versus-host disease or non-relapse mortality. In multivariable analyses ct-KIR score was associated with reduced relapse risk (HR 0.58; P = 0.003) and a trend towards improved event-free survival (HR 0.76; P = 0.059). This effect proved independent of MRD level prior to HSCT. Our data suggest that in children with ALL undergoing HSCT after myeloablative conditioning, donor selection based on KIR genotyping holds promise to improve clinical outcome by decreasing relapse risk and prolonged event-free survival.
https://sonar.ch/global/documents/260911
eng
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41409-019-0543-z
info:eu-repo/semantics/altIdentifier/pmid/31089287
Bone marrow transplantation. - 2019
Adolescent
Adult
Child
Child, Preschool
Disease-Free Survival
Donor Selection
Female
Haplotypes
Hematopoietic Stem Cell Transplantation
Humans
Infant
Leukemia, Myeloid, Acute
Male
Polymorphism, Genetic
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Receptors, KIR
Survival Rate
Telomere
Transplantation Conditioning
Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261063
2025-10-24T22:00:19Z
Hao, Hiroyuki
Gabbiani, Giulio
Bochaton-Piallat, Marie-Luce
application/pdf
https://sonar.ch/global/documents/261063
eng
info:eu-repo/semantics/altIdentifier/doi/10.1161/01.atv.0000090130.85752.ed
info:eu-repo/semantics/altIdentifier/issn/1079-5642
info:eu-repo/semantics/openAccess
Arteriosclerosis, Thrombosis, and Vascular Biology. - Ovid Technologies (Wolters Kluwer Health). - 2003, vol. 23, no. 9, p. 1510-1520
Arterial Smooth Muscle Cell Heterogeneity
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261100
2025-10-24T22:00:21Z
Zacchetti G
Dayer R
Rizzoli R
Ammann P
2014
Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects of 2.5 mm in diameter were created in 6-month-old female rats orally fed SrRan (625 mg/kg/d; 5/7 days) or vehicle for 4, 8, or 12 weeks (10 rats per group per time point) from the time of surgery. Tibias were removed. Micro-architecture was determined by micro-computed tomography (µCT) and material level properties by nanoindentation analysis. µCT analysis showed that SrRan administration significantly improved microarchitecture of trabecular bone growing into the defect after 8 and 12 weeks of treatment compared to vehicle. SrRan treatment also accelerated the growth of cortical bone over the defect, but with different kinetics compared to trabecular bone, as the effects were already significant after 4 weeks. Nanoindentation analysis demonstrated that SrRan treatment significantly increased material level properties of both trabecular bone and cortical bone filling the defect compared to vehicle. SrRan accelerates the filling of bone defect by improving cortical and trabecular bone microarchitecture both quantitatively and qualitatively.
application/pdf
https://sonar.ch/global/documents/261100
eng
info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/549785
info:eu-repo/semantics/altIdentifier/pmid/25243150
info:eu-repo/semantics/openAccess
BioMed research international. - 2014
Administration, Oral
Animals
Bone Density Conservation Agents
Female
Insulin-Like Growth Factor I
Osteogenesis
Rats
Rats, Sprague-Dawley
Thiophenes
Tibia
Wound Healing
X-Ray Microtomography
Systemic treatment with strontium ranelate accelerates the filling of a bone defect and improves the material level properties of the healing bone.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261072
2025-10-24T22:00:15Z
Nguyen, Liem
Walburger, Anne
Houben, Edith
Koul, Anil
Muller, Stefan
Morbitzer, Monika
Klebl, Bert
Ferrari, Giorgio
Pieters, Jean
application/pdf
https://sonar.ch/global/documents/261072
eng
info:eu-repo/semantics/altIdentifier/doi/10.1128/jb.187.20.7165.2005
info:eu-repo/semantics/altIdentifier/issn/0021-9193
info:eu-repo/semantics/openAccess
Journal of Bacteriology. - American Society for Microbiology. - 2005, vol. 187, no. 20, p. 7165-7165
Molecular Biology
Microbiology
Role of Protein Kinase G in Growth and Glutamine Metabolism of Mycobacterium bovis BCG
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261212
2025-10-24T22:00:56Z
Morris, Brett M
Davenport, James R A
Giles, Helen A C
Hebb, Leslie
Hawley, Suzanne L
Angus, Ruth
Gilman, Peter A
Agol, Eric
2019
application/pdf
https://sonar.ch/global/documents/261212
eng
info:eu-repo/semantics/altIdentifier/doi/10.1093/mnras/stz199
info:eu-repo/semantics/altIdentifier/issn/0035-8711
info:eu-repo/semantics/openAccess
Monthly Notices of the Royal Astronomical Society. - Oxford University Press (OUP). - 2019, vol. 484, no. 3, p. 3244-3250
Space and Planetary Science
Astronomy and Astrophysics
The solar benchmark: rotational modulation of the Sun reconstructed from archival sunspot records
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261190
2025-10-24T22:00:54Z
Hardy M
Douxfils J
Bareille M
Lessire S
Gouin-Thibault I
Fontana P
Lecompte T
Mullier F
2020
We read with much interest the recent observational study of Nougier et al., which aimed at studying thrombin generation (TG) and fibrinolysis profiles of COVID-19 patients admitted to an intensive care unit (ICU) or to an internal medicine ward and receiving various schemes of prophylactic heparin.[1] They reported that thrombin potential remained within normal range despite heparin and that fibrinolysis was decreased in relation with increased plasminogen activator inhibitor 1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) antigen plasma levels. Using the rotational thromboelastometry (ROTEM) delta device with EXTEM reagents and the addition of 0.625µg/mL tPA (referred to as 'TEM-tPA'), they reported decreased clot lysis in COVID-19 patients, which was more pronounced in patients who presented a thrombotic event, compared to event-free patients.
application/pdf
https://sonar.ch/global/documents/261190
eng
info:eu-repo/semantics/altIdentifier/doi/10.1111/jth.15061
info:eu-repo/semantics/altIdentifier/pmid/32790951
info:eu-repo/semantics/openAccess
Journal of thrombosis and haemostasis : JTH. - 2020
Blood coagulation tests
COVID-19
Factor Xa
Heparin
Thrombelastography
Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance and their limitations.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261191
2025-10-24T22:00:54Z
Eruteya, Ovie Emmanuel
Niyazi, Yakufu
Omosanya, Kamaldeen Olakunle
Ierodiaconou, Daniel
Moscariello, Andrea
2020
<jats:p> Submarine mass wasting plays a fundamental role in transporting substantial volumes of sediments basinward including gigantic slide blocks. However, the understanding of processes involved in block generation and their associated deformation until flow arrest remains limited, especially in data-starved deep-water settings. Here a 2D and 3D seismic reflection data from the Exmouth Plateau, offshore NW Australia is used to investigate the architecture of large blocks preserved within an ancient mass transport complex (MTC) and their interaction with the basal shear surface (BSS). The evolution of the investigated MTC (MTC-BDF) is related to instability along the flanks of an underlying bifurcative Miocene canyon. MTC-BDF spans ∼75 km by ∼35 km containing at least 32 well-imaged blocks (within the 3D seismic coverage) encapsulated in a well-deformed debrite background. These carbonate blocks interpreted as rafted blocks have lengths ranging from 0.48 km to 3.40 km with thicknesses reaching up to 165 m. Interestingly, the blocks are more abundant in a region characterized by moderate-high amplitude debrites. Erosional morphologies encompassing a unique groove and other circular to irregular-shaped depressions mapped along the BSS provide evidence for the erosive nature of the flow. The origin of the groove is related transported blocks gouging the BSS. Importantly, intra block deformations recorded within these blocks as fault and fold systems suggest a complex flow regime within MTC-BDF, with the deformations arising either during block translation or also possibly upon the arrest of the failed mass in interaction with bathymetric elements. Our findings suggest inherent deformations within these blocks may serve as high-permeability conduits with implications for deep-water drilling operations within this segment of the Exmouth Plateau and elsewhere in other hydrocarbon-rich deep-water settings. </jats:p>
https://sonar.ch/global/documents/261191
eng
info:eu-repo/semantics/altIdentifier/doi/10.1190/int-2020-0067.1
info:eu-repo/semantics/altIdentifier/issn/2324-8858
Interpretation. - Society of Exploration Geophysicists. - 2020, p. 1-67
EVOLUTION AND MORPHOLOGY OF RAFTED BLOCKS IN AN ANCIENT DEEPWATER MASS TRANSPORT COMPLEX (EXMOUTH PLATEAU, OFFSHORE NW AUSTRALIA)
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261209
2025-10-24T22:00:56Z
Fekete S
Beck A
Veuthey JL
Guillarme D
2019
Reversed phase liquid chromatography (RPLC) is a widely used technique for the analytical characterization of proteins biopharmaceuticals, due to its inherent compatibility with mass spectrometry (MS). However, this chromatographic mode suffers from limited selectivity when analyzing large molecules. Due to the on/off mechanism observed with large solutes in RPLC (S values were higher than 100 for intact proteins), we have developed a new analytical strategy based on the use of multi-isocratic elution mode, to achieve arbitrary selectivity for protein variants. In this work, it has been demonstrated that the combination of multi-isocratic steps and very short steep gradient segments at solute elution allows one to set the selectivity as desired, while maintaining sharp peaks due to significant band compression effects. The strategy was successfully applied to the analysis of intact and subunits of monoclonal antibodies (mAbs) as well as antibody-drug conjugates (ADCs), illustrating the possibility to achieve a uniform peak distribution (equidistant band spacing) and much higher resolution than in the case of common linear, multilinear, or nonlinear gradients.
https://sonar.ch/global/documents/261209
eng
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.analchem.9b03005
info:eu-repo/semantics/altIdentifier/pmid/31514494
Analytical chemistry. - 2019
Antibodies, Monoclonal
Chromatography, Reverse-Phase
Humans
Immunoconjugates
Mass Spectrometry
Proof of Concept Study
Proof of Concept To Achieve Infinite Selectivity for the Chromatographic Separation of Therapeutic Proteins.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261492
2025-10-24T22:01:44Z
Rügamer, David
Brockhaus, Sarah
Gentsch, Kornelia
Scherer, Klaus
Greven, Sonja
2017
application/pdf
https://sonar.ch/global/documents/261492
eng
info:eu-repo/semantics/altIdentifier/doi/10.1111/rssc.12241
info:eu-repo/semantics/altIdentifier/issn/0035-9254
info:eu-repo/semantics/openAccess
Journal of the Royal Statistical Society: Series C (Applied Statistics). - Wiley. - 2017, vol. 67, no. 3, p. 621-642
Statistics, Probability and Uncertainty
Statistics and Probability
Boosting factor‐specific functional historical models for the detection of synchronization in bioelectrical signals
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261368
2025-10-24T22:01:36Z
Thouverey C
Caverzasio J
2016
Intermittent parathyroid hormone administration (iPTH) increases bone mass and strength by stimulating osteoblast number and activity. PTH exerts its anabolic effects through cAMP/protein kinase A (PKA) signaling pathway in mature osteoblasts and osteocytes. Here, we show that inactivation of the p38α MAPK-encoding gene with the use of an osteocalcin-cre transgene prevents iPTH bone anabolic action. Indeed, iPTH fails to increase insulin-like growth factor 1 expression, osteoblast number and activity, and bone formation in mice lacking p38α in osteoblasts and osteocytes. Moreover, iPTH-induced expression of receptor activator of NF-κB ligand (RANKL) and subsequent increased bone resorption are suppressed in those mice. Finally, we found that PTH activates p38α MAPK downstream of cAMP/PKA signaling pathway in mature osteoblasts. Our findings identify p38α MAPK as a key component of PTH signaling in osteoblast lineage cells and highlight its requirement in iPTH osteoanabolic activity. © 2015 American Society for Bone and Mineral Research.
application/pdf
https://sonar.ch/global/documents/261368
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/jbmr.2762
info:eu-repo/semantics/altIdentifier/pmid/26643857
info:eu-repo/semantics/openAccess
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 2016
BONE ANABOLISM
BONE REMODELING
OSTEOBLASTS
PARATHYROID HORMONE
p38α MAPK
Animals
Cyclic AMP-Dependent Protein Kinases
MAP Kinase Signaling System
Mice, Transgenic
Osteoblasts
Osteocytes
Parathyroid Hormone
RANK Ligand
p38 Mitogen-Activated Protein Kinases
Suppression of p38α MAPK Signaling in Osteoblast Lineage Cells Impairs Bone Anabolic Action of Parathyroid Hormone.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261393
2025-10-24T22:01:39Z
Wilde JCH
Calinescu AM
Wildhaber BE
2018
Biliary atresia (BA) and congenital choledochal malformations (CCM) are rare. Both pathologies must (BA) or may (CCM) be operated during the neonatal period or early infancy. We briefly describe the classical operative techniques for both pathologies, followed by the most common and severe perioperative complications encountered during and up to 30 days after surgery in children operated for BA and CCM early in life. For patients with BA, intestinal complications represent the most common and hazardous perioperative surgical complications. Cholangitis is the most frequently encountered medical complication post hepato-porto-enterostomy. For CCM, it seems that neonates encounter little perioperative complications; however, reports are scarce; bile leak and/or cholangitis are the most reported. Overall, for patients with CCM, the literature is ambivalent whether more perioperative complications occur in the younger or in the older patient, and whether these occur more frequently in those symptomatic or asymptomatic at operation. It is difficult to give clear advice for when children with asymptomatic CCM should be operated, and benefits and risks must be carefully counterbalanced. Perioperative mortality for both BA and CCM is low and is reported to be around 1 to 2%.
https://sonar.ch/global/documents/261393
eng
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0038-1636929
info:eu-repo/semantics/altIdentifier/pmid/29510428
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie. - 2018
Bile Ducts
Biliary Atresia
Choledochal Cyst
Common Bile Duct
Digestive System Surgical Procedures
Humans
Infant
Infant, Newborn
Intraoperative Complications
Perioperative Period
Postoperative Complications
Treatment Outcome
Perioperative Complications in Neonatal Surgery: Biliary Atresia and Choledochal Malformations.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261480
2025-10-24T22:01:44Z
Ferreira, Pedro G
Dermitzakis, Emmanouil T
2013
<jats:p>Changes in gene expression could be used to predict whether individuals will respond successfully to the influenza vaccine.</jats:p>
https://sonar.ch/global/documents/261480
eng
info:eu-repo/semantics/altIdentifier/doi/10.7554/elife.00899
info:eu-repo/semantics/altIdentifier/issn/2050-084X
eLife. - eLife Sciences Publications, Ltd. - 2013, vol. 2
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Medicine
Immune response is a personal matter
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261398
2025-10-24T22:01:48Z
Soldati, Dominique
Santos, Joana
https://sonar.ch/global/documents/261398
eng
info:eu-repo/semantics/altIdentifier/doi/10.3410/f.718196275.793488092
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature. - Faculty Opinions Ltd. - 2013
Faculty Opinions recommendation of RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261536
2025-10-24T22:02:12Z
Borsato, L
Malavolta, L
Piotto, G
Buchhave, L A
Mortier, A
Rice, K
Cameron, A C
Coffinet, A
Sozzetti, A
Charbonneau, D
Cosentino, R
Dumusque, X
Figueira, P
Latham, D W
Lopez-Morales, M
Mayor, M
Micela, G
Molinari, E
Pepe, F
Phillips, D
Poretti, E
Udry, S
Watson, C
2019
application/pdf
https://sonar.ch/global/documents/261536
eng
info:eu-repo/semantics/altIdentifier/doi/10.1093/mnras/stz181
info:eu-repo/semantics/altIdentifier/issn/0035-8711
info:eu-repo/semantics/openAccess
Monthly Notices of the Royal Astronomical Society. - Oxford University Press (OUP). - 2019, vol. 484, no. 3, p. 3233-3243
Space and Planetary Science
Astronomy and Astrophysics
HARPS-N radial velocities confirm the low densities of the Kepler-9 planets
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261550
2025-10-24T22:02:12Z
Pauliat E
Onken M
Weber-Schoendorfer C
Rousson V
Addor MC
Baud D
Théaudin M
Diav-Citrin O
Cottin J
Agusti A
Rollason V
Kaplan YC
Kennedy D
Kadioglu M
Rothuizen LE
Livio F
Buclin T
Panchaud A
Winterfeld U
2020
This prospective multicentre cohort study investigated pregnancy outcomes after fingolimod use for multiple sclerosis during pregnancy. Pregnancy outcomes of 63 fingolimod and 62 interferon-β-exposed pregnancies were compared. Rates of major congenital anomalies (MCA) were 4.8% (2/42) in the fingolimod group versus 2.3% (1/44) in the interferon-β group (odds ratio, 2.2; 95% confidence interval, 0.2-24.6). The adjusted hazard ratio for spontaneous abortion in fingolimod versus interferon-β-exposed pregnancies was 0.6 (95% confidence interval, 0.2-1.8). Further studies are needed to definitely rule out a moderately increased MCA risk after fingolimod exposure during pregnancy.
https://sonar.ch/global/documents/261550
eng
info:eu-repo/semantics/altIdentifier/doi/10.1177/1352458520929628
info:eu-repo/semantics/altIdentifier/pmid/32538681
Multiple sclerosis (Houndmills, Basingstoke, England). - 2020
Fingolimod
birth defect
cohort study
interferon
multiple sclerosis
pregnancy
Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:261581
2025-10-24T22:02:15Z
Seeber, B.
Calzolaio, C.
Zurmühle, D.
Abächerli, V.
Alessandrini, M.
De Marzi, G.
Senatore, C.
https://sonar.ch/global/documents/261581
eng
info:eu-repo/semantics/altIdentifier/doi/10.1063/1.5120272
info:eu-repo/semantics/altIdentifier/issn/0021-8979
Journal of Applied Physics. - AIP Publishing. - 2019, vol. 126, no. 20, p. 203905
General Physics and Astronomy
Reduced strain sensitivity of the critical current of Nb3Sn multifilamentary wires
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257627
2025-10-24T21:44:41Z
Mele, Salvatore
2015
application/pdf
https://sonar.ch/global/documents/257627
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789814644150_0004
info:eu-repo/semantics/altIdentifier/issn/1793-1339
info:eu-repo/semantics/openAccess
Advanced Series on Directions in High Energy Physics. - WORLD SCIENTIFIC. - 2015, p. 89-106
The Measurement of the Number of Light Neutrino Species at LEP
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257534
2025-10-24T21:44:32Z
ICHIM, D.
PAVESE, F.
BALLE, C.
CASAS-CUBILLOS, J.
2011
application/pdf
https://sonar.ch/global/documents/257534
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789812811684_0023
info:eu-repo/semantics/openAccess
Advanced Mathematical and Computational Tools in Metrology V. - WORLD SCIENTIFIC. - 2001
TOOLS FOR QUALITY TESTING OF BATCHES OF ARTIFACTS: THE CRYOGENIC THERMOMETERS FOR THE LHC
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257573
2025-10-24T21:44:36Z
WU, TAI TSUN
2011
application/pdf
https://sonar.ch/global/documents/257573
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789812795083_0013
info:eu-repo/semantics/openAccess
Symmetry and Modern Physics. - WORLD SCIENTIFIC. - 2003
REMARKS ON YANG–MILLS THEORY
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257572
2025-10-24T21:44:36Z
MENGONI, A.
VENTURA, A.
CAPOTE, R.
2011
https://sonar.ch/global/documents/257572
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789812795151_0114
Capture Gamma-Ray Spectroscopy and Related Topics. - WORLD SCIENTIFIC. - 2003
SHAPE TRANSITIONS IN THE INTERACTING BOSON MODEL AT FINITE TEMPERATURE
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257576
2025-10-24T21:44:36Z
WILLIAMS, M. C. S.
2011
https://sonar.ch/global/documents/257576
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789812776464_0080
Advanced Technology and Particle Physics. - WORLD SCIENTIFIC. - 2002
DEVELOPMENT OF HIGH TIME RESOLUTION MULTIGAP RPCS FOR THE TOF DETECTOR OF ALICE
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257605
2025-10-24T21:44:40Z
Antoniadis, I.
2012
https://sonar.ch/global/documents/257605
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789812701794_0007
From Quarks to Black Holes. - WORLD SCIENTIFIC. - 2005
How many dimensions are really compactified?
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257594
2025-10-24T21:44:39Z
Fabjan, Christian W.
2003
https://sonar.ch/global/documents/257594
eng
info:eu-repo/semantics/altIdentifier/doi/10.1002/3527600434.eap092
digital Encyclopedia of Applied Physics. - Wiley-VCH Verlag GmbH & Co. KGaA. - 2003
Detectors, Particle, Calorimetric
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257604
2025-10-24T21:44:39Z
Veneziano, G.
2012
https://sonar.ch/global/documents/257604
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/9789812708427_0009
How and Where to Go Beyond the Standard Model. - WORLD SCIENTIFIC. - 2007
The Hidden SUSY face of QCD
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257798
2025-10-24T21:44:48Z
Soha, Aria
Gorisek, Andrej
Zavrtanik, Marko
Sokhranyi, Grygorii
McGoldrick, Garrin
Cerv, Matevz
2014
application/pdf
https://sonar.ch/global/documents/257798
eng
info:eu-repo/semantics/altIdentifier/doi/10.2172/1296767
info:eu-repo/semantics/openAccess
ATLAS DBM Module Qualification
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257686
2025-10-24T21:44:45Z
Moreno Llácer, M.
2018
<jats:p> The top quark is the heaviest elementary particle and unique among the known quarks since it decays before forming hadronic bound states. This makes measurements of the top quark itself particularly interesting as one can access directly the properties of a bare quark. The latest measurements of these properties with the ATLAS detector are reported using data from 8 TeV and 13 TeV proton-proton collisions at the Large Hadron Collider at CERN. The latest measurements of the top quark mass using template methods, as well as others aiming to measure the mass in a well-defined scheme, are presented. In addition, measurements for the top quark decay width, top quark spin observables and [Formula: see text]-boson helicity in events with top quark pairs ([Formula: see text]) are presented and compared to the Standard Model predictions. The cross-section measurements of top quark pair production in association with a photon, [Formula: see text]- or [Formula: see text]-boson are also reported and compared to the most accurate theoretical calculations. These measurements probe the top quark electroweak couplings. Limits on the rate of flavour-changing neutral current processes in the production or decay of the top quark are also shown. </jats:p>
application/pdf
https://sonar.ch/global/documents/257686
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/s2010194518600534
info:eu-repo/semantics/altIdentifier/issn/2010-1945
info:eu-repo/semantics/openAccess
International Journal of Modern Physics: Conference Series. - World Scientific Pub Co Pte Lt. - 2018, vol. 46, p. 1860053
Top Quark Mass and Properties Measurements with the ATLAS Detector
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257663
2025-10-24T21:44:44Z
STICHELBAUT, F.
2011
<jats:p> At the end of 1995, the LEP collider at CERN was operated at center-of-mass energies of 130 and 136 GeV and data corresponding to about 6 pb<jats:sup>−1</jats:sup> were collected by each of the four LEP experiments. The cross-sections for fermion-pair production processes and the forward-backward asymmetries for charged lepton pairs were measured and compared to the standard model predictions. Events containing only energetic photons in the final state were used to look for effects arising from new physics. Direct searches for new particles predicted by various models beyond the standard model were performed. Searches for pair or singly produced excited leptons, for unstable charged and neutral heavy leptons, and for supersymmetric particles (chargino, neutralino, scalar leptons and scalar top quark) resulted in new exclusion limits. The ALEPH collaboration reported an excess of four-jet events in its data, which was not confirmed by the other LEP experiments. </jats:p>
https://sonar.ch/global/documents/257663
eng
info:eu-repo/semantics/altIdentifier/doi/10.1142/s0217732396002800
info:eu-repo/semantics/altIdentifier/issn/0217-7323
Modern Physics Letters A. - World Scientific Pub Co Pte Lt. - 1996, vol. 11, no. 36, p. 2809-2823
Nuclear and High Energy Physics
Astronomy and Astrophysics
STUDY OF e+e− INTERACTIONS AT CENTER-OF-MASS ENERGIES OF 130 AND 136 GeV
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257632
2025-10-24T21:44:41Z
Mihara, S.
Miller, J.P.
Paradisi, P.
Piredda, G.
https://sonar.ch/global/documents/257632
eng
info:eu-repo/semantics/altIdentifier/doi/10.1146/annurev-nucl-102912-144530
info:eu-repo/semantics/altIdentifier/issn/0163-8998
Annual Review of Nuclear and Particle Science. - Annual Reviews. - 2013, vol. 63, no. 1, p. 531-552
Nuclear and High Energy Physics
Charged Lepton Flavor–Violation Experiments
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257729
2025-10-24T21:45:02Z
Goeuriot, Lorraine
Kelly, Liadh
Jones, Gareth J.F.
Müller, Henning
Zobel, Justin
application/pdf
https://sonar.ch/global/documents/257729
eng
info:eu-repo/semantics/altIdentifier/doi/10.1145/2701583.2701592
info:eu-repo/semantics/altIdentifier/issn/0163-5840
info:eu-repo/semantics/openAccess
ACM SIGIR Forum. - Association for Computing Machinery (ACM). - 2014, vol. 48, no. 2, p. 78-82
Hardware and Architecture
Management Information Systems
Report on the SIGIR 2014 Workshop on Medical Information Retrieval (MedIR)
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257744
2025-10-24T21:45:13Z
Weidmann P
Gnädinger MP
Schohn D
Riesen W
Jahn H
1989
To evaluate the potential therapeutic value of calcium antagonists in hypertension associated with impaired renal function, blood pressure (BP), certain regulatory factors, and metabolic correlates of cardiovascular risk have been assessed in 15 patients with mild to marked chronic renal failure before and after 6 weeks of therapy with nitrendipine. Compared to placebo, nitrendipine (mean final dose 55 mg/day) decreased supine BP from 173/102 to 146/81 mm Hg and upright BP from 170/105 to 145/86 mm Hg. Heart rate, body weight (+0.8 kg) and exchangeable sodium (+176 mmol, not significant) were minimally increased, and plasma and whole blood volume, plasma angiotensin II and creatinine concentrations, and urinary electrolyte and creatinine excretion were not significantly changed. Nitrendipine increased uric acid excretion and lowered plasma uric acid by 24%; glucose, insulin, serum total lipids, and lipoprotein fractions were unchanged.
https://sonar.ch/global/documents/257744
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00558151
info:eu-repo/semantics/altIdentifier/pmid/2744062
European journal of clinical pharmacology. - 1989
Adult
Aged
Angiotensin II
Female
Humans
Hypertension
Kidney Failure, Chronic
Male
Middle Aged
Nitrendipine
Risk Factors
Uric Acid
Antihypertensive and hypouricaemic effects of nitrendipine in chronic renal failure.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257731
2025-10-24T21:45:10Z
Martinelli M
Winterhalder R
Cerretelli P
Howald H
Hoppeler H
1990
Muscle ultrastructural changes during a typical expedition to the Himalayas were analyzed by taking muscle biopsies from seven climbers before and after their sojourn at high altitude (over 5000 m for 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A quantitative evaluation was made of lipofuscin, satellite cells and myonuclei. Significant increases of the volume densities of lipofuscin (+ 235%) and satellite cells (+ 215%) were observed.
https://sonar.ch/global/documents/257731
eng
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf01939930
info:eu-repo/semantics/altIdentifier/pmid/2373192
Experientia. - 1990
Altitude
Biopsy
Cell Nucleus
Humans
Lipofuscin
Male
Muscles
Pigments, Biological
Muscle lipofuscin content and satellite cell volume is increased after high altitude exposure in humans.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257831
2025-10-24T21:45:38Z
Uhlmann V
Ramdya P
Delgado-Gonzalo R
Benton R
Unser M
2017
Understanding the biological underpinnings of movement and action requires the development of tools for quantitative measurements of animal behavior. Drosophila melanogaster provides an ideal model for developing such tools: the fly has unparalleled genetic accessibility and depends on a relatively compact nervous system to generate sophisticated limbed behaviors including walking, reaching, grooming, courtship, and boxing. Here we describe a method that uses active contours to semi-automatically track body and leg segments from video image sequences of unmarked, freely behaving D. melanogaster. We show that this approach yields a more than 6-fold reduction in user intervention when compared with fully manual annotation and can be used to annotate videos with low spatial or temporal resolution for a variety of locomotor and grooming behaviors. FlyLimbTracker, the software implementation of this method, is open-source and our approach is generalizable. This opens up the possibility of tracking leg movements in other species by modifications of underlying active contour models.
application/pdf
https://sonar.ch/global/documents/257831
eng
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0173433
info:eu-repo/semantics/altIdentifier/pmid/28453566
info:eu-repo/semantics/openAccess
PloS one. - 2017
Algorithms
Animals
Behavior, Animal
Drosophila melanogaster
Female
Hindlimb
Image Processing, Computer-Assisted
Movement
FlyLimbTracker: An active contour based approach for leg segment tracking in unmarked, freely behaving Drosophila.
http://purl.org/coar/resource_type/c_6501
oai:sonar.ch:257829
2025-10-24T21:45:38Z
Brechbuhl C
Girard O
Millet GP
Schmitt L
2017
PURPOSE
We investigated technical and physiological responses along with their relationships during an incremental field test to exhaustion specific to tennis (TEST) in elite players.
METHODS
Twenty male elite tennis players completed TEST, which consisted of hitting alternatively forehand and backhand strokes at increasing ball frequency (ball machine) every minute. Ball accuracy (BA), ball velocity (BV), and tennis performance (TP) index (TP = BA × BV) were determined by radar and video analysis for each stroke, in addition to cardiorespiratory responses and blood lactate concentrations.
RESULTS
At low intensities (less than 80% of maximal oxygen uptake [V˙O2max]), technical performance was steady. From 80% to 100% of V˙O2max, significant and steady decreases in BV (-9.0% and -13.3%; P = 0.02 and P = 0.002), BA (-19.4% and -18.4%; both P < 0.001), and TP (-27.4% and -29.15%; both P = 0.002) occurred for forehands and backhands, respectively. Changes in TP and blood lactate concentration from 60% to 100% of V˙O2max were inversely correlated (r = -0.51, P = 0.008). BV was 5.2% higher (P = 0.042) for forehand versus backhand, and there was no difference between strokes for both BA (P = 0.930) and TP (P = 0.536).
CONCLUSION
Technical alterations (i.e., decrease in BV, BA, and TP) in elite players undergoing TEST only occurred at high intensity (>80% of V˙O2max), presumably because of the use of compensatory strategies to overcome fatigue. Above this intensity, all technical indices decreased steadily until exhaustion, independently of the stroke nature.
https://sonar.ch/global/documents/257829
eng
info:eu-repo/semantics/altIdentifier/doi/10.1249/MSS.0000000000001303
info:eu-repo/semantics/altIdentifier/pmid/28422770
Medicine and science in sports and exercise. - 2017
Adolescent
Athletic Performance
Exercise Test
Humans
Lactic Acid
Male
Muscle Fatigue
Oxygen Consumption
Tennis
Time and Motion Studies
Young Adult
Technical Alterations during an Incremental Field Test in Elite Male Tennis Players.
http://purl.org/coar/resource_type/c_6501
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