Chemical Purification of Terbium-155 from Pseudo-Isobaric Impurities in a Mass Separated Source Produced at CERN.
- Webster B National Physical Laboratory, Teddington, TW11 0LW, UK.
- Ivanov P National Physical Laboratory, Teddington, TW11 0LW, UK. peter.ivanov@npl.co.uk.
- Russell B National Physical Laboratory, Teddington, TW11 0LW, UK.
- Collins S National Physical Laboratory, Teddington, TW11 0LW, UK.
- Stora T CERN - European Organization for Nuclear Research, Esplanade des Particules 1, 1217, Meyrin, Switzerland.
- Ramos JP CERN - European Organization for Nuclear Research, Esplanade des Particules 1, 1217, Meyrin, Switzerland.
- Köster U Institut Laue-Langevin, 38042, Grenoble, France.
- Robinson AP National Physical Laboratory, Teddington, TW11 0LW, UK.
- Read D National Physical Laboratory, Teddington, TW11 0LW, UK.
- 2019-07-28
Published in:
- Scientific reports. - 2019
English
Four terbium radioisotopes (149, 152, 155, 161Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive 139Ce16O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate 155Tb with a chemical yield of ≥95% and radionuclidic purity ≥99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting 155Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1038/s41598-019-47463-3
- PMID 31350422
- Persistent URL
- https://sonar.ch/global/documents/100002
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