Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.
- Dotto GP Department of Biochemistry, University of Lausanne, Epalinges 1066, Switzerland; Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA. Electronic address: paolo.dotto@unil.ch.
- Rustgi AK Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: anil2@mail.med.upenn.edu.
- 2016-05-12
Published in:
- Cancer cell. - 2016
Alcohol Drinking
Carcinoma, Squamous Cell
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Infections
Models, Genetic
Mutation
Smoking
Ultraviolet Rays
English
Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell-fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic, and epigenetic studies, and complementary functional analysis. The evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1016/j.ccell.2016.04.004
- PMID 27165741
- Persistent URL
- https://sonar.ch/global/documents/100192
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