Journal article
The utility of 68Gallium-DOTATATE PET/CT in the detection of von Hippel-Lindau disease associated tumors.
- Shell J Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States.
- Tirosh A Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States; Neuroendocrine Tumors Service, Chaim Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Israel. Electronic address: amit.tirosh@nih.gov.
- Millo C Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States; PET Imaging Center, National Institutes of Health Clinical Center, Bethesda, Maryland, United States.
- Sadowski SM Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland.
- Assadipour Y Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA, United States.
- Green P Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States.
- Patel D Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States.
- Nilubol N Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States.
- Kebebew E Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia, United States.
- 2019-02-20
Published in:
- European journal of radiology. - 2019
(68)Ga-DOTATATE
PET/CT
von Hippel-Lindau
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuroendocrine Tumors
Organometallic Compounds
Positron Emission Tomography Computed Tomography
Prospective Studies
Radionuclide Imaging
Radiopharmaceuticals
Tomography, X-Ray Computed
von Hippel-Lindau Disease
English
PURPOSE
Patients with von Hippel-Lindau (VHL) disease may develop various tumors, including neuroendocrine tumors of the pancreas (PNETs) and adrenal, central nervous system and retinal hemangioblastomas, kidney tumors and more. 68Ga-DOTATATE positron emission tomography (PET)/computerized tomography (CT) has been shown to be highly accurate for tumors with cells expressing somatostatin receptors. We aimed to assess the performance of 68Ga-DOTATATE PET/CT in patients with VHL disease.
METHODS
Patients with a diagnosis of VHL were enrolled in a prospective study and underwent surveillance imaging for pancreatic lesions (n = 301). The current analysis includes 73 evaluations with multiple imaging modalities of 36 patients (2.1 ± 0.8 evaluations/patient, range 1-4) for a head-to-head comparison of 68Ga-DOTATATE PET/CT, CT and/or MRI. In this post-hoc analysis we compared the detection rates of various imaging modalities for PNETs and for any extrapancreatic tumors located within the scan field of CT/MRI of the abdomen.
RESULTS
68Ga-DOTATATE PET/CT detected a total of 206 lesions, CT detected 208 lesions and MRI detected 94 lesions in 61, 66 and 33 scans, respectively. 68Ga-DOTATATE PET/CT (3.4 ± 0.1 per scan) was superior than CT (3.2 ± 0.1 per scan, p = 0.02) with a similar trend when comparing with MRI (2.8 ± 0.1 per scan, p = 0.03) in detecting lesions in any anatomic locations.
CONCLUSIONS
68Ga-DOTATATE PET/CT had a significantly higher detection rate when compared with anatomic imaging for all lesions, and comparable detection rate for pancreatic lesions in VHL patients. Hence, given the higher accuracy and lower radiation exposure associated with 68Ga-DOTATATE PET/CT, its potential role in the surveillance of VHL-associated lesions should be further studied.
Patients with von Hippel-Lindau (VHL) disease may develop various tumors, including neuroendocrine tumors of the pancreas (PNETs) and adrenal, central nervous system and retinal hemangioblastomas, kidney tumors and more. 68Ga-DOTATATE positron emission tomography (PET)/computerized tomography (CT) has been shown to be highly accurate for tumors with cells expressing somatostatin receptors. We aimed to assess the performance of 68Ga-DOTATATE PET/CT in patients with VHL disease.
METHODS
Patients with a diagnosis of VHL were enrolled in a prospective study and underwent surveillance imaging for pancreatic lesions (n = 301). The current analysis includes 73 evaluations with multiple imaging modalities of 36 patients (2.1 ± 0.8 evaluations/patient, range 1-4) for a head-to-head comparison of 68Ga-DOTATATE PET/CT, CT and/or MRI. In this post-hoc analysis we compared the detection rates of various imaging modalities for PNETs and for any extrapancreatic tumors located within the scan field of CT/MRI of the abdomen.
RESULTS
68Ga-DOTATATE PET/CT detected a total of 206 lesions, CT detected 208 lesions and MRI detected 94 lesions in 61, 66 and 33 scans, respectively. 68Ga-DOTATATE PET/CT (3.4 ± 0.1 per scan) was superior than CT (3.2 ± 0.1 per scan, p = 0.02) with a similar trend when comparing with MRI (2.8 ± 0.1 per scan, p = 0.03) in detecting lesions in any anatomic locations.
CONCLUSIONS
68Ga-DOTATATE PET/CT had a significantly higher detection rate when compared with anatomic imaging for all lesions, and comparable detection rate for pancreatic lesions in VHL patients. Hence, given the higher accuracy and lower radiation exposure associated with 68Ga-DOTATATE PET/CT, its potential role in the surveillance of VHL-associated lesions should be further studied.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.ejrad.2018.11.023
- PMID 30777201
- Persistent URL
- https://sonar.ch/global/documents/100596
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