Journal article
Interplay of H-Bonds with Aromatics in Isolated Complexes Identifies Isomeric Carbohydrates.
- Saparbaev E Laboratoire de Chimie Physique Moléculaire, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
- Kopysov V Laboratoire de Chimie Physique Moléculaire, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
- Yamaletdinov R Nikolaev Institute of Inorganic Chemistry, Novosibirsk, 630090, Russian Federation.
- Pereverzev AY Laboratoire de Chimie Physique Moléculaire, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
- Boyarkin OV Laboratoire de Chimie Physique Moléculaire, École Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
- 2019-03-30
Published in:
- Angewandte Chemie (International ed. in English). - 2019
English
The tremendous isomeric diversity of carbohydrates enables a wide range of their biological functions but makes the identification and study of these molecules difficult. We investigated the ability of intermolecular interactions to communicate structural specificity of carbohydrates to protonated aromatic molecules in non-covalent complexes, isolated and cooled in the gas phase. Our study revealed that small structural differences between carbohydrate isomers of any type, including enantiomers, are accurately communicated by these interactions to aromatic molecules as detectable changes in their electronic excitation spectra. The specific response of the aromatics to the isomers of carbohydrates is fine-tuned by the interplay of the various involved non-covalent bonds. These findings enable the gas-phase identification and relative quantification of any isomers of oligosaccharides in their solution mixtures using the 2D UV-MS fingerprinting technique.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1002/anie.201902377
- PMID 30924999
- Persistent URL
- https://sonar.ch/global/documents/10159
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