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Journal article

Novel targeted therapies for eosinophil-associated diseases and allergy.

  • 2014-10-24
Published in:
  • Annual review of pharmacology and toxicology. - 2015
asthma
biologicals
chronic eosinophilic leukemia
hypereosinophilic syndrome
tyrosine kinase inhibitors
Animals
Anti-Allergic Agents
Drug Discovery
Eosinophilia
Eosinophils
Humans
Hypersensitivity
Molecular Targeted Therapy
Signal Transduction
English Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/103
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