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The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.

  • van Bilsen M Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Hospital, Maastricht, the Netherlands.
  • Patel HC National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.
  • Bauersachs J Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany.
  • Böhm M Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.
  • Borggrefe M First Department of Medicine, Cardiology Division, University Medical Centre Mannheim, Mannheim, Germany.
  • Brutsaert D Department of Cardiology, Antwerp University, Antwerp, Belgium.
  • Coats AJS Department of Medicine, Monash University, Melbourne, Vic, Australia.
  • de Boer RA Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
  • de Keulenaer GW Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium.
  • Filippatos GS Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Athens University Hospital Attikon, Athens, Greece.
  • Floras J University Health Network and Sinai Health System Division of Cardiology, Peter Munk Cardiac Centre, Toronto General and Lunenfeld-Tanenbaum Research Institutes, University of Toronto, Toronto, ON, Canada.
  • Grassi G Clinica Medica, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
  • Jankowska EA Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
  • Kornet L Medtronic, Inc., Bakken Research Centre, Maastricht, the Netherlands.
  • Lunde IG Institute for Experimental Medical Research, Oslo University Hospital, University of Oslo, Oslo, Norway.
  • Maack C Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.
  • Mahfoud F Clinic for Internal Medicine III, Cardiology, Angiology and Intensive Internal Medicine, Homburg, Germany.
  • Pollesello P Critical Care, Orion Pharma, Espoo, Finland.
  • Ponikowski P Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
  • Ruschitzka F University Heart Centre, University Hospital Zurich, Zurich, Switzerland.
  • Sabbah HN Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI, USA.
  • Schultz HD Department of Cellular and Integrative Physiology, University of Nebraska College of Medicine, Omaha, NE, USA.
  • Seferovic P Department of Cardiology, Belgrade University Medical Centre, Belgrade, Serbia.
  • Slart RHJA Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
  • Taggart P Department of Cardiovascular Science, University College London, Barts Heart Centre, London, UK.
  • Tocchetti CG Department of Translational Medical Sciences, Federico II University, Naples, Italy.
  • Van Laake LW Department of Cardiology, Heart and Lungs Division, and Regenerative Medicine Centre, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Zannad F INSERM, Centre for Clinical Investigation 9501, Unit 961, University Hospital Centre, Nancy, France.
  • Heymans S Netherlands Heart Institute, Utrecht, the Netherlands.
  • Lyon AR National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK.
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  • 2017-09-27
Published in:
  • European journal of heart failure. - 2017
Autonomic dysfunction
Devices and nerve ablation
Heart failure
Parasympathetic
Sympathetic
Autonomic Nervous System
Cardiology
Consensus
Europe
Heart Failure
Humans
Societies, Medical
Translational Medical Research
English Despite improvements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burdens on patients and health care systems worldwide. Alterations in autonomic nervous system (ANS) activity contribute to cardiac disease progression, and the recent development of invasive techniques and electrical stimulation devices has opened new avenues for specific targeting of the sympathetic and parasympathetic branches of the ANS. The Heart Failure Association of the European Society of Cardiology recently organized an expert workshop which brought together clinicians, trialists and basic scientists to discuss the ANS as a therapeutic target in HF. The questions addressed were: (i) What are the abnormalities of ANS in HF patients? (ii) What methods are available to measure autonomic dysfunction? (iii) What therapeutic interventions are available to target the ANS in patients with HF, and what are their specific strengths and weaknesses? (iv) What have we learned from previous ANS trials? (v) How should we proceed in the future?
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/103255
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