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Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke.

  • Biasiucci A Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
  • Leeb R Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
  • Iturrate I Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
  • Perdikis S Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
  • Al-Khodairy A SUVACare - Clinique Romande de Réadaptation, Sion, 1951, Switzerland.
  • Corbet T Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
  • Schnider A Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, 1211, Switzerland.
  • Schmidlin T Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Sion, 1951, Switzerland.
  • Zhang H Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland.
  • Bassolino M Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Sion, 1951, Switzerland.
  • Viceic D Center for Neuroprosthetics, École Polytechnique Fédérale de Lausanne, Sion, 1951, Switzerland.
  • Vuadens P SUVACare - Clinique Romande de Réadaptation, Sion, 1951, Switzerland.
  • Guggisberg AG Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, 1211, Switzerland.
  • Millán JDR Defitech Foundation Chair in Brain-Machine Interface, Center for Neuroprosthetics and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Geneva, 1202, Switzerland. jose.millan@epfl.ch.
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  • 2018-06-22
Published in:
  • Nature communications. - 2018
Arm
Brain
Brain-Computer Interfaces
Electric Stimulation Therapy
Electroencephalography
Female
Humans
Male
Middle Aged
Movement
Neural Pathways
Neuronal Plasticity
Recovery of Function
Stereotaxic Techniques
Stroke
Stroke Rehabilitation
Treatment Outcome
English Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinically relevant, and lasting motor recovery in chronic stroke survivors more effectively than sham FES. Such recovery is associated to quantitative signatures of functional neuroplasticity. BCI patients exhibit a significant functional recovery after the intervention, which remains 6-12 months after the end of therapy. Electroencephalography analysis pinpoints significant differences in favor of the BCI group, mainly consisting in an increase in functional connectivity between motor areas in the affected hemisphere. This increase is significantly correlated with functional improvement. Results illustrate how a BCI-FES therapy can drive significant functional recovery and purposeful plasticity thanks to contingent activation of body natural efferent and afferent pathways.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/103504
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