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The Ccr4-Not Complex: Architecture and Structural Insights.
Journal article

The Ccr4-Not Complex: Architecture and Structural Insights.

  • Collart MA Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, 1 rue Michel Servet, Geneva, Switzerland. martine.collart@unige.ch.
  • Panasenko OO Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, 1 rue Michel Servet, Geneva, Switzerland.
  • 2017-03-09
Published in:
  • Sub-cellular biochemistry. - 2017
Ccr4-Not complex
Deadenylation
Eukaryotic gene expression
RING E3 ligase
Transcription
Ubiquitination
mRNA decay
Humans
Multiprotein Complexes
Nuclear Receptor Subfamily 4, Group A, Member 2
Protein Binding
Receptors, CCR4
Ribonucleases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription Factors
English The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 protein, and two Ccr4 associated factors, Caf1 and Caf40. A fourth Not protein, Not4, is conserved, but is only a stable subunit of the complex in yeast. Certain subunits have been duplicated during evolution, with functional divergence, such as Not3 in yeast, and Ccr4 or Caf1 in human. However the complex includes only one homolog for each protein. In addition, species-specific subunits are part of the complex, such as Caf130 in yeast or Not10 and Not11 in human. Two conserved catalytic functions are associated with the complex, deadenylation and ubiquitination . The complex adopts an L-shaped structure, in which different modules are bound to a large Not1 scaffold protein. In this chapter we will summarize our current knowledge of the architecture of the complex and of the structure of its constituents.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/103520
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