Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole.
- Suter C Institute of Parasitology, University of Zurich, Switzerland.
- Müller-Doblies UU
- Hatt JM
- Deplazes P
- 2001-05-04
Published in:
- The Veterinary record. - 2001
Animals
Antibodies, Protozoan
Antinematodal Agents
Encephalitozoon cuniculi
Encephalitozoonosis
Fenbendazole
Fluorescent Antibody Technique, Indirect
Rabbits
English
The efficacy of fenbendazole for preventing an experimental infection of Encephalitozoon cuniculi and for eliminating the spores from the central nervous system of naturally infected rabbits was investigated. Fenbendazole (20 mg/kg bodyweight daily) was administered from seven days before until two or 21 days after rabbits had been infected orally with 10(6) spores of E. cuniculi. Both regimens were effective in preventing the establishment of the parasites, as demonstrated by negative parasitic-specific serology and by the failure to isolate the parasite from brain tissue. In naturally infected, seropositive rabbits, parasites were successfully isolated from seven of nine untreated animals, but not from the brain tissue of eight animals treated with fenbendazole-medicated pellets for four weeks.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1136/vr.148.15.478
- PMID 11334074
- Persistent URL
- https://sonar.ch/global/documents/103770
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