Journal article
Thalamic control of cortical states.
- Poulet JF Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
- Fernandez LM
- Crochet S
- Petersen CC
- 2012-01-24
Published in:
- Nature neuroscience. - 2012
Action Potentials
Afferent Pathways
Animals
Channelrhodopsins
Cortical Synchronization
Denervation
Electric Stimulation
Fourier Analysis
Mice
Mice, Transgenic
Neurons
Somatosensory Cortex
Thalamus
Vibrissae
Wakefulness
English
We investigated the impact of thalamus on ongoing cortical activity in the awake, behaving mouse. We demonstrate that the desynchronized cortical state during active behavior is driven by a centrally generated increase in thalamic action potential firing, which can also be mimicked by optogenetic stimulation of the thalamus. The thalamus therefore is key in controlling cortical states.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1038/nn.3035
- PMID 22267163
- Persistent URL
- https://sonar.ch/global/documents/104872
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