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Journal article

Use of VacA as a Vaccine Antigen.

  • Moyat M Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, CLE D203, CHUV, 155 Chemin des Boveresses, CH-1066 Epalinges, Switzerland. mati.moyat@epfl.ch.
  • Velin D Service of Gastroenterology and Hepatology, Department of Medicine, Lausanne University Hospital, CLE D203, CHUV, 155 Chemin des Boveresses, CH-1066 Epalinges, Switzerland. dominique.velin@chuv.ch.
  • 2016-06-25
Published in:
  • Toxins. - 2016
H. pylori
VacA
vaccine
Animals
Antigens, Bacterial
Bacterial Proteins
Bacterial Toxins
Humans
Vaccines
English One of the major toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA) named after its ability to induce the formation of "vacuole"-like membrane vesicles in the cytoplasm of gastric cells. VacA has been associated with the disruption of mitochondrial functions, stimulation of apoptosis, blockade of T cell proliferation and promotion of regulatory T cells, thereby making it a promising vaccine target. Immunity to bacterial virulence factors is well known to protect humans against bacterial infections; hence, detoxified VacA has been evaluated as a vaccine antigen. Our short review summarizes the pre-clinical and clinical data that have been published on the use of VacA in the development of the H. pylori vaccine.
Language
  • English
Open access status
gold
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https://sonar.ch/global/documents/106108
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