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Cells and secretome--towards endogenous cell re-activation for cartilage repair.
Journal article

Cells and secretome--towards endogenous cell re-activation for cartilage repair.

  • Stoddart MJ AO Research Institute Davos, 7270 Davos Platz, Switzerland. Electronic address: Martin.stoddart@aofoundation.org.
  • Bara J AO Research Institute Davos, 7270 Davos Platz, Switzerland. Electronic address: Jennifer.bara@aofoundation.org.
  • Alini M AO Research Institute Davos, 7270 Davos Platz, Switzerland. Electronic address: Mauro.alini@aofoundation.org.
  • 2014-09-02
Published in:
  • Advanced drug delivery reviews. - 2015
Cartilage repair
Cell therapy
Cytokines
Paracrine
Regenerative medicine
Scaffolds
Biological Factors
Cartilage
Chondrogenesis
Guided Tissue Regeneration
Humans
Mesenchymal Stem Cells
Regenerative Medicine
English Regenerative medicine approaches to cartilage tissue repair have mainly been concerned with the implantation of a scaffold material containing monolayer expanded cells into the defect, with the aim to differentiate the cells into chondrocytes. While this may be a valid approach, the secretome of the implanted cells and its effects on the endogenous resident cells, is gaining in interest. This review aims to summarize the knowledge on the secretome of mesenchymal stem cells, including knowledge from other tissues, in order to indicate how these mechanisms may be of value in repairing articular cartilage defects. Potential therapies and their effects on the repair of articular cartilage defects will be discussed, with a focus on the transition from classical cell therapy to the implantation of cell free matrices releasing specific cytokines.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/106139
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