Journal article
Domino asymmetric conjugate addition-conjugate addition.
- Germain N Department of Organic Chemistry, University of Geneva , Quai Ernest Ansermet, 30, 1211 Geneva 4, Switzerland.
- Schlaefli D
- Chellat M
- Rosset S
- Alexakis A
- 2014-03-26
Published in:
- Organic letters. - 2014
English
Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ol5005752
- PMID 24661026
- Persistent URL
- https://sonar.ch/global/documents/106392
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