Comparison of Tigecycline and Vancomycin for Treatment of Experimental Foreign-Body Infection Due to Methicillin-Resistant Staphylococcus aureus
- Vaudaux, Pierre Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
- Fleury, Bénédicte Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
- Gjinovci, Asllan Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
- Huggler, Elzbieta Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
- Tangomo-Bento, Manuela Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
- Lew, Daniel P. Service of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
Published in:
- Antimicrobial Agents and Chemotherapy. - American Society for Microbiology. - 2009, vol. 53, no. 7, p. 3150-3152
English
ABSTRACT
Twice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 μg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1128/aac.01612-08
- ISSN 0066-4804
- Persistent URL
- https://sonar.ch/global/documents/106401
Statistics
Document views: 20
File downloads:
- Full-text: 0