IMMUNOGLOBULIN D AS A LYMPHOCYTE RECEPTOR
- Rowe, David S. From the World Health Organization Immunology Research and Training Centre, Institut de Biochimie, Université de Lausanne, 1011 Lausanne, Switzerland, and the Basle Institute for Immunology, CH-4058 Basle, Switzerland
- Hug, Katharina From the World Health Organization Immunology Research and Training Centre, Institut de Biochimie, Université de Lausanne, 1011 Lausanne, Switzerland, and the Basle Institute for Immunology, CH-4058 Basle, Switzerland
- Forni, Luciana From the World Health Organization Immunology Research and Training Centre, Institut de Biochimie, Université de Lausanne, 1011 Lausanne, Switzerland, and the Basle Institute for Immunology, CH-4058 Basle, Switzerland
- Pernis, Benvenuto From the World Health Organization Immunology Research and Training Centre, Institut de Biochimie, Université de Lausanne, 1011 Lausanne, Switzerland, and the Basle Institute for Immunology, CH-4058 Basle, Switzerland
- 1973-10-1
Published in:
- Journal of Experimental Medicine. - Rockefeller University Press. - 1973, vol. 138, no. 4, p. 965-972
English
A large proportion of the human peripheral blood lymphocytes of adults and newborns having IgD were found also to have IgM on their membranes and vice versa. A few lymphocytes had one of these classes only. IgD and IgM could be capped independently on the same cell. The possibility that IgD was acquired by a cytophilic process was excluded by the finding that IgD-bearing cells were of one light chain type only, and by the direct demonstration of reappearance of IgD on the lymphocyte membrane during incubation in an IgD-free culture medium. On the basis of these findings, it is proposed that IgD functions as a lymphocyte antigen receptor.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1084/jem.138.4.965
- ISSN 1540-9538
- Persistent URL
- https://sonar.ch/global/documents/106700
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