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Small angle x-ray scattering with edge-illumination.
Journal article

Small angle x-ray scattering with edge-illumination.

  • Modregger P Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT London, United Kingdom.
  • Cremona TP Institute of Anatomy, University of Berne, Baltzerstrasse 2, 3012 Bern, Switzerland.
  • Benarafa C Theodor Kocher Institute, University of Berne, Freiestrasse 1, 3012 Bern, Switzerland.
  • Schittny JC Institute of Anatomy, University of Berne, Baltzerstrasse 2, 3012 Bern, Switzerland.
  • Olivo A Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT London, United Kingdom.
  • Endrizzi M Department of Medical Physics and Bioengineering, University College London, Gower Street, WC1E 6BT London, United Kingdom.
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  • 2016-08-06
Published in:
  • Scientific reports. - 2016
Animals
Contrast Media
Humans
Image Processing, Computer-Assisted
Mice
Mice, 129 Strain
Pulmonary Emphysema
Radiography
Scattering, Small Angle
X-Ray Diffraction
X-Rays
English Sensitivity to sub-pixel sample features has been demonstrated as a valuable capability of phase contrast x-ray imaging. Here, we report on a method to obtain angular-resolved small angle x-ray scattering distributions with edge-illumination- based imaging utilizing incoherent illumination from an x-ray tube. Our approach provides both the three established image modalities (absorption, differential phase and scatter strength), plus a number of additional contrasts related to unresolved sample features. The complementarity of these contrasts is experimentally validated by using different materials in powder form. As a significant application example we show that the extended complementary contrasts could allow the diagnosis of pulmonary emphysema in a murine model. In support of this, we demonstrate that the properties of the retrieved scattering distributions are consistent with the expectation of increased feature sizes related to pulmonary emphysema. Combined with the simplicity of implementation of edge-illumination, these findings suggest a high potential for exploiting extended sub-pixel contrasts in the diagnosis of lung diseases and beyond.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/107143
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