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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Journal article

Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.

  • Ottaviani G LCT-Pharmacochimie, Section des Sciences Pharmaceutiques, Université de Genève, Quai Ernest-Ansermet 30, CH-1211, Genève 4, Switzerland.
  • Martel S
  • Carrupt PA
  • 2006-06-23
Published in:
  • Journal of medicinal chemistry. - 2006
1-Octanol
Diffusion
Dimethylpolysiloxanes
Humans
In Vitro Techniques
Membranes, Artificial
Myristates
Permeability
Skin
Skin Absorption
Water
English This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for a set of compounds using the PAMPA technique with isopropyl myristate (IPM) and silicone oil, alone or in mixture, were compared to the corresponding human skin permeability coefficient values (Kp). A good correlation between Pe and Kp was found for compounds tested through a membrane consisting of 70% silicone and 30% IPM. Moreover, positive correlation between the membrane retention of compounds and stratum corneum/water partition coefficients (PSC) was established. These results showed that this new artificial membrane, defined as PAMPA-skin, is able to mimic the main barrier properties of human stratum corneum and can be used for the fast prediction of passive human skin permeability coefficients.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/108435
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