A brief history of TOR.
- Loewith R Department of Molecular Biology, National Centres of Competence in Research Frontiers in Genetics and Chemical Biology, University of Geneva, Sciences III, 30 quai Ernest Ansermet, CH-1211 Geneva, Switzerland. Robbie.Loewith@unige.ch
- 2011-03-25
Published in:
- Biochemical Society transactions. - 2011
Amino Acids
Animals
History, 20th Century
Humans
Molecular Biology
Protein-Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sirolimus
Transcription Factors
English
The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an antifungal agent, studies with yeast have contributed greatly to our understanding of the molecular pathways in which TORs operate. Recently, building on advances in quantitative MS, the rapamycin-dependent phosphoproteome in the budding yeast Saccharomyces cerevisiae was elucidated. These studies emphasize the central importance of TOR and highlight its many previously unrecognized functions. One of these, the regulation of intermediary metabolism, is discussed.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1042/BST0390437
- PMID 21428915
- Persistent URL
- https://sonar.ch/global/documents/109107
Statistics
Document views: 27
File downloads:
- Full-text: 0