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Imaging technology of the lymphatic system.
Journal article

Imaging technology of the lymphatic system.

  • Polomska AK ETH Zürich, Institute of Pharmaceutical Sciences, Vladimir-Prelog Weg 1-5/10, 8093 Zürich, Switzerland.
  • Proulx ST University of Bern, Theodor Kocher Institute, Freiestrasse 1, 3012 Bern, Switzerland. Electronic address: steven.proulx@tki.unibe.ch.
  • 2020-09-06
Published in:
  • Advanced drug delivery reviews. - 2020
Contractility
Lymph node
Lymphangiography
Lymphatic system
Lymphatic vessel
Lymphscintigraphy
MRI
NIR fluorescence
Tracer
English The lymphatic system plays critical roles in tissue fluid homeostasis and immunity and has been implicated in the development of many different pathologies, ranging from lymphedema, the spread of cancer to chronic inflammation. In this review, we first summarize the state-of-the-art of lymphatic imaging in the clinic and the advantages and disadvantages of these existing techniques. We then detail recent progress on imaging technology, including advancements in tracer design and injection methods, that have allowed visualization of lymphatic vessels with excellent spatial and temporal resolution in preclinical models. Finally, we describe the different approaches to quantifying lymphatic function that are being developed and discuss some emerging topics for lymphatic imaging in the clinic. Continued advancements in lymphatic imaging technology will be critical for the optimization of diagnostic methods for lymphatic disorders and the evaluation of novel therapies targeting the lymphatic system.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/111248
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