COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.
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Scarfò L
Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy.
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Chatzikonstantinou T
Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
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Rigolin GM
Hematology Section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
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Quaresmini G
USC Ematologia, ASST PAPA GIOVANNI XXIII, Bergamo, Italy.
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Motta M
S.C. Ematologia, ASST Spedali Civili, Brescia, Italy.
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Vitale C
University Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
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Garcia-Marco JA
Hematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain.
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Hernández-Rivas JÁ
Hospital Universitario Infanta Leonor, Madrid Universidad Complutense, Madrid, Spain.
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Mirás F
Hospital Universitario 12 de Octubre, Madrid, Spain.
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Baile M
Servicio de Hematología del Complejo Asistencial Universitario de Salamanca-IBSAL, Salamanca, Spain.
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Marquet J
Hematology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
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Niemann CU
Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
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Reda G
U.O.C. Ematologia, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy.
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Munir T
St James's University Hospital, Leeds, UK.
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Gimeno E
Hematology Department Hospital del Mar, Barcelona, Spain.
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Marchetti M
Hematology Dpt, Az Osp SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
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Quaglia FM
Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.
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Varettoni M
Division of Haematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
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Delgado J
Dept. of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain.
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Iyengar S
Department of Haemato-Oncology, Royal Marsden Hospital, London, UK.
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Janssens A
Universitaire Ziekenhuizen Leuven, Leuven, Belgium.
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Marasca R
Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
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Ferrari A
Hematology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
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Cuéllar-García C
Hematology Unit, Consorci Sanitari Terrassa Hospital, Terrassa, Spain.
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Itchaki G
Rabin Medical Center, Beilinson Hospital; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Špaček M
1st Department of Medicine-Department of Hematology, First Faculty of Medicine, Charles University and General Hospital in Prague, Prague, Czech Republic.
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De Paoli L
Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
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Laurenti L
Dipartimento Scienze Radiologiche ed Ematologiche, Divisione di Ematologia Fondazione Policlinico universitario A Gemelli, Roma, Italy.
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Levin MD
Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
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Lista E
Struttura Semplice Dipartimentale di Ematologia, Presidio Ospedaliero Santa Chiara, Trento, Italy.
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Mauro FR
Hematology, Department of Translational and Precision Medicine, Sapienza University, Policlinico Umberto I, Rome, Italy.
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Šimkovič M
Department of Internal Medicine-Haematology, University Hospital and Medical School Hradec Kralove, Hradec Kralove, Czech Republic.
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Van Der Spek E
Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.
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Vandenberghe E
Department of Haematology, St James Hospital and Trinity College Dublin, Dublin, Ireland.
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Trentin L
Hematology Unit, University of Padua, Padua, Italy.
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Wasik-Szczepanek E
Dept. Hematooncology and Bone Marrow Transplantation, Medical University in Lublin, Lublin, Poland.
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Ruchlemer R
Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
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Bron D
Inst J Bordet (ULB), Brussels, Belgium.
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De Paolis MR
UOC Ematologia PO Vito Fazzi Lecce, Lecce, Italy.
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Del Poeta G
Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione, Università Tor Vergata Roma, Rome, Italy.
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Farina L
Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
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Foglietta M
SC Ematologia, AO S. Croce e Carle, Cuneo, Italy.
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Gentile M
UOC Ematologia AO Cosenza, Cosenza, Italy.
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Herishanu Y
Department of Hematology, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.
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Herold T
Department of Medicine III, University Hospital, LMU Munich, Munich, Germany.
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Jaksic O
Department of Hematology, University hospital Dubrava, Zagreb, Croatia.
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Kater AP
Dep of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
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Kersting S
Department of Hematology, Haga Hospital, The Hague, The Netherlands.
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Malerba L
Hematology Unit, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.
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Orsucci L
Division of Hematology II, San Giovanni Battista Hospital, Torino, Italy.
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Popov VM
Colentina Clinical Hospital Bucharest, Bucharest, Romania.
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Sportoletti P
Institute of Hematology and Center for Hemato-Oncological Research, Ospedale S. Maria della Misericordia, University of Perugia, Perugia, Italy.
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Yassin M
National Center for Cancer Care and Research Doha, Doha, Qatar.
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Pocali B
Division of Hematology and Stem Cell Transplantation Unit, Cardarelli Hospital, Naples, Italy.
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Barna G
1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
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Chiarenza A
Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Italy.
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Dos Santos G
Hospital de Clinicas, Montevideo, Uruguay.
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Nikitin E
Department of Hematology, Oncology, and Chemotherapy, S. P. Botkin's City Hospital, Moscow, Russia.
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Andres M
Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
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Dimou M
1st First Propedeutic Department of Internal Medicine, Hematology Unit, Laikon General Hospital, National and Kapodistrian University of Athens, Medical School of Athens, Athens, Greece.
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Doubek M
University Hospital and CEITEC MU Brno, Brno, Czech Republic.
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Enrico A
Hematology Area, Hospital Italiano La Plata, La Plata, Argentina.
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Hakobyan Y
Hematology Center after Prof. Yeolyan MH RA, Yerevan, Armenia.
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Kalashnikova O
First State Pavlov Medical University of Saint-Petersburg, Raisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation Russia, Saint-Petersburg, Russia.
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Ortiz Pareja M
Carlos Haya, Málaga, Spain.
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Papaioannou M
Hematology Unit, 1st Dept of Internal Medicine, AUTH, AHEPA Hospital, Thessaloniki, Greece.
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Rossi D
Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland.
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Shah N
Norfolk & Norwich University NHS Foundation Trust, Norwich, UK.
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Shrestha A
Hematology Unit, Nepal Cancer Hospital & Research Centre, Lalitpur, Nepal.
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Stanca O
"Carol Davila" University of Medicine and Pharmacy, Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania.
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Stavroyianni N
Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece.
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Strugov V
Hematology Almazov National Medical Research Centre, St. Petersburg, Russia.
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Tam C
Peter MacCallum Cancer Centre and University of Melbourne, Victoria, Australia.
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Zdrenghea M
Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy and Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania.
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Coscia M
University Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
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Stamatopoulos K
Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. kostas.stamatopoulos@certh.gr.
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Rossi G
S.C. Ematologia, ASST Spedali Civili, Brescia, Italy.
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Rambaldi A
USC Ematologia, ASST PAPA GIOVANNI XXIII, Bergamo, Italy.
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Montserrat E
Dept. of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain.
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Foà R
Hematology, Department of Translational and Precision Medicine, Sapienza University, Policlinico Umberto I, Rome, Italy.
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Cuneo A
Hematology Section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
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Ghia P
Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy. ghia.paolo@hsr.it.
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English
Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (≥65 years) (odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (≤12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. Of 151 patients with severe disease, 55 (36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency.
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bronze
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https://sonar.ch/global/documents/111354
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