Do women have impaired regional systolic function in hypertensive heart disease? A 3-dimensional echocardiography study.
- Frielingsdorf J Heart Center, City Hospital Triemli, Birmensdorferstrasse 497, 8063 Zürich, and Cardiology, University Hospital, Bern, Switzerland. juergen.frielingsdorf@triemli.stzh.ch
- Genoni M
- Hess OM
- Flachskampf FA
- 2006-03-21
Published in:
- European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology. - 2007
Female
Heart Ventricles
Humans
Hypertension
Hypertrophy, Left Ventricular
Male
Middle Aged
Prospective Studies
Sex Factors
Stroke Volume
Systole
Ultrasonography
English
AIMS
In pressure overload left ventricular (LV) hypertrophy, gender-related differences in global LV systolic function have been previously reported. The goal of this study was to determine regional systolic function of the left ventricle in male and female patients with hypertensive heart disease.
METHODS AND RESULTS
Regional LV function was analyzed from multiplane transesophageal echocardiography with three-dimensional (3D) reconstruction of the left ventricle. In 24 patients (13 males and 11 females), four parallel (2 basal and 2 apical) equidistant short axis cross-sections from base to apex were obtained from the reconstructed LV. In each short axis 24 wall-thickness measurements were carried out at 15 degrees intervals at end-diastole and end-systole. Thus, a total of 192 measurements were obtained in each patient. Wall thickening was calculated as difference of end-diastolic and end-systolic wall thickness, and fractional thickening as thickening divided by end-diastolic thickness. Fractional thickening and wall stress were inversely related to end-diastolic wall thickness in both, males and females. Females showed less LV systolic function when compared to males (p<0.001). However, when corrected for wall stress, which was higher in females, there was no gender difference in systolic function.
CONCLUSION
There are regional differences in LV systolic function in females and males which are directly related to differences in wall stress. Thus, gender-related differences in LV regional function are load-dependent and not due to structural differences.
In pressure overload left ventricular (LV) hypertrophy, gender-related differences in global LV systolic function have been previously reported. The goal of this study was to determine regional systolic function of the left ventricle in male and female patients with hypertensive heart disease.
METHODS AND RESULTS
Regional LV function was analyzed from multiplane transesophageal echocardiography with three-dimensional (3D) reconstruction of the left ventricle. In 24 patients (13 males and 11 females), four parallel (2 basal and 2 apical) equidistant short axis cross-sections from base to apex were obtained from the reconstructed LV. In each short axis 24 wall-thickness measurements were carried out at 15 degrees intervals at end-diastole and end-systole. Thus, a total of 192 measurements were obtained in each patient. Wall thickening was calculated as difference of end-diastolic and end-systolic wall thickness, and fractional thickening as thickening divided by end-diastolic thickness. Fractional thickening and wall stress were inversely related to end-diastolic wall thickness in both, males and females. Females showed less LV systolic function when compared to males (p<0.001). However, when corrected for wall stress, which was higher in females, there was no gender difference in systolic function.
CONCLUSION
There are regional differences in LV systolic function in females and males which are directly related to differences in wall stress. Thus, gender-related differences in LV regional function are load-dependent and not due to structural differences.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.euje.2006.02.001
- PMID 16545984
- Persistent URL
- https://sonar.ch/global/documents/1114
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