Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.
Journal article

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.

  • Nagornov KO Spectroswiss Sàrl, EPFL Innovation Park, 1015, Lausanne, Switzerland.
  • Kozhinov AN Spectroswiss Sàrl, EPFL Innovation Park, 1015, Lausanne, Switzerland.
  • Tsybin YO Spectroswiss Sàrl, EPFL Innovation Park, 1015, Lausanne, Switzerland. tsybin@spectroswiss.ch.
  • 2017-02-19
Published in:
  • Journal of the American Society for Mass Spectrometry. - 2017
English The phenomenon of ion cyclotron resonance allows for determining mass-to-charge ratio, m/z, of an ensemble of ions by means of measurements of their cyclotron frequency, ω c . In Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), the ω c quantity is usually unavailable for direct measurements: the resonant state is located close to the reduced cyclotron frequency (ω+), whereas the ω c and the corresponding m/z values may be calculated via theoretical derivation from an experimental estimate of the ω+ quantity. Here, we describe an experimental observation of a new resonant state, which is located close to the ω c frequency and is established because of azimuthally-dependent trapping electric fields of the recently developed ICR cells with narrow aperture detection electrodes. We show that in mass spectra, peaks close to ω+ frequencies can be reduced to negligible levels relative to peaks close to ω c frequencies. Due to reduced errors with which the ω c quantity is obtained, the new resonance provides a means of cyclotron frequency measurements with precision greater than that achieved when ω+ frequency peaks are employed. The described phenomenon may be considered for a development into an FT-ICR MS technology with increased mass accuracy for applications in basic research, life, and environmental sciences. Graphical Abstract ᅟ.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/112006
Statistics

Document views: 52 File downloads: