Convergent genomic signatures of domestication in sheep and goats.

Alberto FJ; Boyer F; Orozco-terWengel P; Streeter I; Servin B; de Villemereuil P; Benjelloun B; Librado P; Biscarini F; Colli L; Barbato M; Zamani W; Alberti A; Engelen S; Stella A; Joost S; Ajmone-Marsan P; Negrini R; Orlando L; Rezaei HR; Naderi S; Clarke L; Flicek P; Wincker P; Coissac E; Kijas J; Tosser-Klopp G; Chikhi A; Bruford MW; Taberlet P; Pompanon F

doi:10.1038/s41467-018-03206-y

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Convergent genomic signatures of domestication in sheep and goats.

Alberto FJ Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Boyer F Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Orozco-terWengel P School of Biosciences, Cardiff University, Museum Avenue, CF10 3AX, Cardiff, Wales, UK.
Streeter I European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Servin B GenPhySE, INRA, INPT, ENVT, Université de Toulouse, 31326, Castanet-Tolosan, France.
de Villemereuil P Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Benjelloun B Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Librado P Centre for GeoGenetics, Natural History Museum of Denmark, Øster Voldade 5-7, 1350K, Copenhagen, Denmark.
Biscarini F PTP Science Park, Bioinformatics Unit, Via Einstein-Loc. Cascina Codazza, 26900, Lodi, Italy.
Colli L Istituto di Zootecnica, Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del S. Cuore, via Emilia Parmense n. 84, 29122, Piacenza (PC), Italy.
Barbato M School of Biosciences, Cardiff University, Museum Avenue, CF10 3AX, Cardiff, Wales, UK.
Zamani W Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Alberti A CEA - Institut de biologie François-Jacob, Genoscope, 2 rue Gaston Crémieux, 91057, Evry, France.
Engelen S CEA - Institut de biologie François-Jacob, Genoscope, 2 rue Gaston Crémieux, 91057, Evry, France.
Stella A PTP Science Park, Bioinformatics Unit, Via Einstein-Loc. Cascina Codazza, 26900, Lodi, Italy.
Joost S Laboratory of Geographic Information Systems (LASIG), School of Architecture, Civil and Environmental Engineering (ENAC), Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.
Ajmone-Marsan P Istituto di Zootecnica, Facoltà di Scienze Agrarie, Alimentari e Ambientali, Università Cattolica del S. Cuore, via Emilia Parmense n. 84, 29122, Piacenza (PC), Italy.
Negrini R BioDNA - Centro di Ricerca sulla Biodiversità e DNA Antico, Facoltà di Scienze Agrarie, Alimentarie e Ambientali, Università Cattolica del S. Cuore, via Emilia Parmense n. 84, 29122, Piacenza (PC), Italy.
Orlando L Centre for GeoGenetics, Natural History Museum of Denmark, Øster Voldade 5-7, 1350K, Copenhagen, Denmark.
Rezaei HR Department of Environmental Sci, Gorgan University of Agricultural Sciences & Natural Resources, 41996-13776, Gorgan, Iran.
Naderi S Environmental Sciences Department, Natural Resources Faculty, University of Guilan, 49138-15749, Guilan, Iran.
Clarke L European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Flicek P European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
Wincker P CEA - Institut de biologie François-Jacob, Genoscope, 2 rue Gaston Crémieux, 91057, Evry, France.
Coissac E Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Kijas J CSIRO Agriculture, 306 Carmody Road, St. Lucia, QLD, 4067, Australia.
Tosser-Klopp G GenPhySE, INRA, INPT, ENVT, Université de Toulouse, 31326, Castanet-Tolosan, France.
Chikhi A Institut National de la Recherche Agronomique Maroc (INRA-Maroc), Centre Régional d'Errachidia, Errachidia, 52000, Morocco.
Bruford MW School of Biosciences, Cardiff University, Museum Avenue, CF10 3AX, Cardiff, Wales, UK.
Taberlet P Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France.
Pompanon F Univ. Grenoble Alpes, Univ. Savoie Mont Blanc, CNRS, LECA, F-38000, Grenoble, France. francois.pompanon@univ-grenoble-alpes.fr.

2018-03-08

Published in:

Nature communications. - 2018

English The evolutionary basis of domestication has been a longstanding question and its genetic architecture is becoming more tractable as more domestic species become genome-enabled. Before becoming established worldwide, sheep and goats were domesticated in the fertile crescent 10,500 years before present (YBP) where their wild relatives remain. Here we sequence the genomes of wild Asiatic mouflon and Bezoar ibex in the sheep and goat domestication center and compare their genomes with that of domestics from local, traditional, and improved breeds. Among the genomic regions carrying selective sweeps differentiating domestic breeds from wild populations, which are associated among others to genes involved in nervous system, immunity and productivity traits, 20 are common to Capra and Ovis. The patterns of selection vary between species, suggesting that while common targets of selection related to domestication and improvement exist, different solutions have arisen to achieve similar phenotypic end-points within these closely related livestock species.

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