Journal article
Trifluoromethylation of ketones and aldehydes with Bu₃SnCF₃.
- Sanhueza IA Laboratory for Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
- Bonney KJ
- Nielsen MC
- Schoenebeck F
- 2013-07-10
Published in:
- The Journal of organic chemistry. - 2013
English
The (trifluoromethyl)stannane reagent, Bu3SnCF3, was found to react under CsF activation with ketones and aldehydes to the corresponding trifluoromethylated stannane ether intermediates at room temperature in high yield. Only a mildly acidic extraction (aqueous NH4Cl) is required to release the corresponding trifluoromethyl alcohol products. The protocol is compatible with acid-sensitive functional groups.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/jo401099e
- PMID 23834264
- Persistent URL
- https://sonar.ch/global/documents/112912
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