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Journal article

FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans.

  • 2011-08-09
Published in:
  • The EMBO journal. - 2011
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Cycle
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor Proteins
Gene Expression Regulation
RNA-Binding Proteins
Stem Cells
English Although the decision between stem cell self-renewal and differentiation has been linked to cell-cycle modifications, our understanding of cell-cycle regulation in stem cells is very limited. Here, we report that FBF/Pumilio, a conserved RNA-binding protein, promotes self-renewal of germline stem cells by repressing CKI-2(Cip/Kip), a Cyclin E/Cdk2 inhibitor. We have previously shown that repression of CYE-1 (Cyclin E) by another RNA-binding protein, GLD-1/Quaking, promotes germ cell differentiation. Together, these findings suggest that a post-transcriptional regulatory circuit involving FBF and GLD-1 controls the self-renewal versus differentiation decision in the germline by promoting high CYE-1/CDK-2 activity in stem cells, and inhibiting CYE-1/CDK-2 activity in differentiating cells.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/114595
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