Journal article

Associations of autozygosity with a broad range of human phenotypes.

  • Clark DW Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Okada Y Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
  • Moore KHS deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Mason D Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, BD96RJ, UK.
  • Pirastu N Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Gandin I Research Unit, Area Science Park, Trieste, 34149, Italy.
  • Mattsson H Unit of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
  • Barnes CLK Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Lin K Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Zhao JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Deelen P Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
  • Rohde R Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • Schurmann C The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Guo X Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Giulianini F Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
  • Zhang W Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Medina-Gomez C Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Karlsson R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Bao Y Institute for Social and Economic Research, University of Essex, Colchester, CO4 3SQ, UK.
  • Bartz TM Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, 98101, USA.
  • Baumbach C Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Biino G Institute of Molecular Genetics, National Research Council of Italy, Pavia, 27100, Italy.
  • Bixley MJ Department of Biochemistry, University of Otago, Dunedin, 9054, New Zealand.
  • Brumat M Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Chai JF Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
  • Corre T Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.
  • Cousminer DL Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Dekker AM Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
  • Eccles DA Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, 4059, Australia.
  • van Eijk KR Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
  • Fuchsberger C Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
  • Gao H Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Germain M INSERM UMR_S 1166, Sorbonne Universités, Paris, 75013, France.
  • Gordon SD QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
  • de Haan HG Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
  • Harris SE Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Hofer E Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
  • Huerta-Chagoya A CONACyT, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 03940, México.
  • Igartua C Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
  • Jansen IE Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, 1081 HV, The Netherlands.
  • Jia Y Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Kacprowski T Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.
  • Karlsson T Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75108, Uppsala, Sweden.
  • Kleber ME Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Li SA Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Lab for Cancer Research, Frederick, MD, USA.
  • Li-Gao R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
  • Mahajan A Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
  • Matsuda K Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan.
  • Meidtner K Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Meng W Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, UK.
  • Montasser ME Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA.
  • van der Most PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Munz M Institute for Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany.
  • Nutile T Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR, Naples, 80131, Italy.
  • Palviainen T Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
  • Prasad G Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India.
  • Prasad RB Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Skåne University Hospital, Malmö, 20502, Sweden.
  • Priyanka TDS Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, 500007, India.
  • Rizzi F ePhood Scientific Unit, ePhood SRL, Bresso (Milano), 20091, Italy.
  • Salvi E Department of Health Sciences, University of Milano, Milano, 20139, Italy.
  • Sapkota BR Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
  • Shriner D Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Skotte L Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DK-2300, Denmark.
  • Smart MC Institute for Social and Economic Research, University of Essex, Colchester, CO4 3SQ, UK.
  • Smith AV Icelandic Heart Association, Kopavogur, 201, Iceland.
  • van der Spek A Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Spracklen CN Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Strawbridge RJ Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, UK.
  • Tajuddin SM Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
  • Trompet S Department of Cardiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.
  • Turman C Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
  • Verweij N University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands, Groningen, 9713 GZ, the Netherlands.
  • Viberti C Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
  • Wang L Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110-1093, USA.
  • Warren HR NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Wootton RE MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
  • Yanek LR Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Yao J Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Yousri NA Department of Genetic Medicine, Weill Cornell Medicine Qatar, Doha, Qatar.
  • Zhao W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Adeyemo AA Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Afaq S Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Aguilar-Salinas CA Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 14080, México.
  • Akiyama M Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
  • Albert ML Immunobiology of Dendritic Cells, Institut Pasteur, Paris, 75015, France.
  • Allison MA Division of Preventive Medicine, Department of Family Medicine and Public Health, UC San Diego School of Medicine, La Jolla, California, 92093, USA.
  • Alver M Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
  • Aung T Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Azizi F Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
  • Bentley AR Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Boeing H Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Boerwinkle E Health Science Center at Houston, UTHealth School of Public Health, University of Texas, Houston, TX, 77030, USA.
  • Borja JB USC-Office of Population Studies Foundation, Inc., Department of Nutrition and Dietetics, Talamban, University of San Carlos, Cebu City, 6000, Cebu, Philippines.
  • de Borst GJ Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
  • Bottinger EP The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Broer L Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Campbell H Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Chanock S Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Chee ML Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Chen G Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Chen YI Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Chen Z Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Chiu YF Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan, Taiwan.
  • Cocca M Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 34137, Italy.
  • Collins FS National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.
  • Concas MP Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 34137, Italy.
  • Corley J Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Cugliari G Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
  • van Dam RM Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
  • Damulina A Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
  • Daneshpour MS Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
  • Day FR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Delgado GE Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Dhana K Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Doney ASF MEMO Research, Molecular and Clinical Medicine, University of Dundee, Dundee, DD19SY, UK.
  • Dörr M Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany.
  • Doumatey AP Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Dzimiri N Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, KSA, 12713, Saudi Arabia.
  • Ebenesersdóttir SS deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Elliott J Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Elliott P Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Ewert R Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany.
  • Felix JF Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Fischer K Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
  • Freedman BI Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27101, US.
  • Girotto G Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Goel A Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
  • Gögele M Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
  • Goodarzi MO Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
  • Graff M Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • Granot-Hershkovitz E Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
  • Grodstein F Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
  • Guarrera S Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
  • Gudbjartsson DF deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Guity K Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
  • Gunnarsson B deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Guo Y Chinese Academy of Medical Sciences, Beijing, 100730, China.
  • Hagenaars SP Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Haiman CA Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, 90089, USA.
  • Halevy A Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
  • Harris TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
  • Hedayati M Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
  • van Heel DA Blizard Institute, Queen Mary University of London, London, E1 2AT, UK.
  • Hirata M Laboratory of Genome Technology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
  • Höfer I Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
  • Hsiung CA Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan, Taiwan.
  • Huang J Shanghai Institute of Hematology, State Key Laboratory Of Medical Genomics, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 200025, China.
  • Hung YJ Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan branch, Taipei, Taiwan, Taiwan.
  • Ikram MA Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Jagadeesan A deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Jousilahti P Unit of Public Health Promotion, National Institute for Health and Welfare, Helsinki, Finland.
  • Kamatani Y Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
  • Kanai M Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.
  • Kerrison ND MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Kessler T Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, 80636, Germany.
  • Khaw KT Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.
  • Khor CC Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • de Kleijn DPV Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
  • Koh WP Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
  • Kolcic I Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.
  • Kraft P Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, 02115, USA.
  • Krämer BK Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Kutalik Z Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
  • Kuusisto J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
  • Langenberg C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Launer LJ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
  • Lawlor DA MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
  • Lee IT Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan.
  • Lee WJ Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan.
  • Lerch MM Department of Internal Medicine A, University Medicine Greifswald, Greifswald, 17475, Germany.
  • Li L Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, 100191, China.
  • Liu J Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, SG, Singapore.
  • Loh M Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • London SJ National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, 27709, USA.
  • Loomis S Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
  • Lu Y The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Luan J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Mägi R Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
  • Manichaikul AW Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
  • Manunta P Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Università Vita Salute San Raffaele, Milano, 20132, Italy.
  • Másson G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Matoba N Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
  • Mei XW Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Meisinger C Helmholtz Zentrum München, Independent Research Group Clinical Epidemiology, Neuherberg, 85764, Germany.
  • Meitinger T Institute of Human Genetics, Helmholtz Zentrum Muenchen, Neuherberg, 85764, Germany.
  • Mezzavilla M Medical Genetics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
  • Milani L Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
  • Millwood IY Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Momozawa Y Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
  • Moore A Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Morange PE Laboratory of Haematology, La Timone Hospital, Marseille, France.
  • Moreno-Macías H Departamento de Economía, Universidad Autónoma Metropolitana, Mexico, 09340, México.
  • Mori TA Medical School, The University of Western Australia, Perth, Western Australia/Australia, 6009, Australia.
  • Morrison AC The University of Texas Health Science Center at Houston, School of Public Health, Department of Epidemiology, Human Genetics and Environmental Sciences, Houston, Texas, 77030, USA.
  • Muka T Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Murakami Y Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
  • Murray AD The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, AB25 2ZD, UK.
  • de Mutsert R Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
  • Mychaleckyj JC Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
  • Nalls MA Laboratory of Neurogenetics, Bethesda, MD, 20892, USA.
  • Nauck M DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
  • Neville MJ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Headington, Oxford, OX3 7LJ, UK.
  • Nolte IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Ong KK MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Orozco L Instituto Nacional de Medicina Genómica, Mexico, 14610, México.
  • Padmanabhan S Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
  • Pálsson G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Pankow JS Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
  • Pattaro C Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
  • Pattie A Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Polasek O Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia.
  • Poulter N International Centre for Circulatory Health, Imperial College London, London, W2 1PG, UK.
  • Pramstaller PP Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
  • Quintana-Murci L Human Evolutionary Genetics Unit, Institut Pasteur, Paris, 75015, France.
  • Räikkönen K Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, University of Helsinki, Helsinki, 00014, Finland.
  • Ralhan S Hero Heart Institute and Dyanand Medical College and Hospital, Ludhiana, Punjab, India.
  • Rao DC Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • van Rheenen W Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
  • Rich SS Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
  • Ridker PM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
  • Rietveld CA Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.
  • Robino A Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 34137, Italy.
  • van Rooij FJA Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Ruggiero D Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR, Naples, 80131, Italy.
  • Saba Y Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry, Medical University of Graz, 8010, Graz, Austria.
  • Sabanayagam C Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Sabater-Lleal M Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, 171 76, Sweden.
  • Sala CF San Raffaele Research Institute, Milano, Italy.
  • Salomaa V Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
  • Sandow K Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Schmidt H Gottfried Schatz Research Center (for Cell Signaling, Metabolism and Aging), Division of Molecular Biology and Biochemistry, Medical University of Graz, 8010, Graz, Austria.
  • Scott LJ Department of Biostatistics, and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, 48109, USA.
  • Scott WR Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Sedaghati-Khayat B Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran.
  • Sennblad B Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, 171 76, Sweden.
  • van Setten J Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3485 CX, Netherlands.
  • Sever PJ International Centre for Circulatory Health, Imperial College London, London, W2 1PG, UK.
  • Sheu WH School of Medicine, National Defense Medical Center, Taipei, Taiwan, Taiwan.
  • Shi Y Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Shrestha S Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, 500007, India.
  • Shukla SR Diabetes Unit, KEM Hospital and Research Centre, Pune, Maharashtra, 411101, India.
  • Sigurdsson JK deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Sikka TT Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
  • Singh JR Panjab University, Chandigarh, India.
  • Smith BH Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
  • Stančáková A Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
  • Stanton A RCSI Molecular & Cellular Therapeutics (MCT), Royal College of Surgeons in Ireland, RCSI Education & Research Centre, Beaumont Hospital, Dublin 9, Ireland.
  • Starr JM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Stefansdottir L deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Straker L School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Western Australia/Australia, 6102, Australia.
  • Sulem P deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Sveinbjornsson G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Swertz MA Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
  • Taylor AM Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
  • Taylor KD Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Terzikhan N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Tham YC Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Thorleifsson G deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Thorsteinsdottir U deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Tillander A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Tracy RP Department of Pathology, University of Vermont, Colchester, VT, 05446, USA.
  • Tusié-Luna T Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Mexico, 04510, México.
  • Tzoulaki I Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Vaccargiu S Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Rome, Italy.
  • Vangipurapu J Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
  • Veldink JH Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
  • Vitart V MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, Scotland.
  • Völker U Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.
  • Vuoksimaa E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
  • Wakil SM Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, KSA, 12713, Saudi Arabia.
  • Waldenberger M Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Wander GS Department of Cardiology, Hero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, Punjab, 141001, India.
  • Wang YX Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China, 100005, China.
  • Wareham NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Wild S Centre for Population Health Sciences, Usher Institute of Population Health and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Yajnik CS Diabetes Unit, K.E.M. Hospital Research Centre, Pune, MAH, 411011, India.
  • Yuan JM Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Zeng L Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, 80636, Germany.
  • Zhang L Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Zhou J Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Amin N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Asselbergs FW Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
  • Bakker SJL Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9713GZ, The Netherlands.
  • Becker DM Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
  • Lehne B Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Bennett DA Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
  • van den Berg LH Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht University, Utrecht, 3584 CX, The Netherlands.
  • Berndt SI Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Bharadwaj D Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India.
  • Bielak LF Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Bochud M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
  • Boehnke M Department of Biostatistics, and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, 48109, USA.
  • Bouchard C Pennington Biomedical Research Center, Baton Rouge, Louisiane, 70808, USA.
  • Bradfield JP Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Brody JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
  • Campbell A Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
  • Carmi S Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
  • Caulfield MJ NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Cesarini D Center for Experimental Social Science, Department of Economics, New York University, New York, New York, 10012, USA.
  • Chambers JC Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Chandak GR Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, 500007, India.
  • Cheng CY Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Ciullo M Institute of Genetics and Biophysics A. Buzzati-Traverso - CNR, Naples, 80131, Italy.
  • Cornelis M Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
  • Cusi D Department of Health Sciences, University of Milano, Milano, 20139, Italy.
  • Smith GD MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
  • Deary IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Dorajoo R Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 138672, Singapore.
  • van Duijn CM Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Ellinghaus D Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany.
  • Erdmann J Institute for Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany.
  • Eriksson JG Department of General Practice and Primary health Care, University of Helsinki, Tukholmankatu 8 B, Helsinki, 00014, Finland.
  • Evangelou E Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
  • Evans MK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
  • Faul JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
  • Feenstra B Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DK-2300, Denmark.
  • Feitosa M Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Saint Louis, MO, 63110-1093, USA.
  • Foisy S Montreal Heart Institute, Montreal, QC, Canada.
  • Franke A Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105, Kiel, Germany.
  • Friedlander Y Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
  • Gasparini P Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
  • Gieger C Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Gonzalez C Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, 01120, México.
  • Goyette P Montreal Heart Institute, Montreal, QC, Canada.
  • Grant SFA Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Griffiths LR Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, 4059, Australia.
  • Groop L Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
  • Gudnason V Icelandic Heart Association, Kopavogur, 201, Iceland.
  • Gyllensten U Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75108, Uppsala, Sweden.
  • Hakonarson H Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Hamsten A Cardiovascular Medicine Unit, Department of Medicine Solna, Centre for Molecular Medicine, Stockholm, 171 76, Sweden.
  • van der Harst P University of Groningen, University Medical Center Groningen, Department of Cardiology, Ther Netherlands, Groningen, 9713 GZ, the Netherlands.
  • Heng CK Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Hicks AA Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, 39100, Italy.
  • Hochner H Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
  • Huikuri H Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, 90014, Finland.
  • Hunt SC Department of Genetic Medicine, Weill Cornell Medicine Qatar, Doha, Qatar.
  • Jaddoe VWV Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • De Jager PL Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 650 West 168th street, PH19-311, Newyork, NY, 10032, USA.
  • Johannesson M Department of Economics, Stockholm School of Economics, Stockholm, SE-113 83, Sweden.
  • Johansson Å Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75108, Uppsala, Sweden.
  • Jonas JB Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China, 100005, China.
  • Jukema JW Department of Cardiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.
  • Junttila J Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, 90014, Finland.
  • Kaprio J Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.
  • Kardia SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Karpe F Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Headington, Oxford, OX3 7LJ, UK.
  • Kumari M Institute for Social and Economic Research, University of Essex, Colchester, CO4 3SQ, UK.
  • Laakso M Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
  • van der Laan SW Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, 3584 CX, Netherlands.
  • Lahti J Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, University of Helsinki, Helsinki, 00014, Finland.
  • Laudes M University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Kiel, 24105, Germany.
  • Lea RA Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, 4059, Australia.
  • Lieb W Institute of Epidemiology and PopGen Biobank, University of Kiel, Kiel, Schleswig Holstein, 24105, Germany.
  • Lumley T Department of Statistics, University of Auckland, Auckland, New Zealand.
  • Martin NG QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
  • März W Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, 68167, Germany.
  • Matullo G Italian Institute for Genomic Medicine (IIGM) and Dept. Medical Sciences, University of Turin, Italy, Turin, 10126, Italy.
  • McCarthy MI Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
  • Medland SE QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
  • Merriman TR Department of Biochemistry, University of Otago, Dunedin, 9054, New Zealand.
  • Metspalu A Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
  • Meyer BF Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.
  • Mohlke KL Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Montgomery GW QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
  • Mook-Kanamori D Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
  • Munroe PB NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • North KE Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • Nyholt DR QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
  • O'connell JR Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA.
  • Ober C Department of Human Genetics, University of Chicago, Chicago, IL, 60637, USA.
  • Oldehinkel AJ Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
  • Palmas W Department of Medicine, Columbia University Medical Center, New York, New York, USA.
  • Palmer C Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, The School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.
  • Pasterkamp GG Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
  • Patin E Human Evolutionary Genetics Unit, Institut Pasteur, Paris, 75015, France.
  • Pennell CE School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.
  • Perusse L Department of kinesiology, Laval University, Quebec, QC, G1V 0A6, Canada.
  • Peyser PA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Pirastu M Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
  • Polderman TJC Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, 1081 HV, The Netherlands.
  • Porteous DJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
  • Posthuma D Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, 1081 HV, The Netherlands.
  • Psaty BM Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, 98101, USA.
  • Rioux JD Montreal Heart Institute, Montreal, QC, Canada.
  • Rivadeneira F Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Rotimi C Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-5635, USA.
  • Rotter JI Division of Genomic Outcomes, Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, 90502, USA.
  • Rudan I Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Den Ruijter HM Laboratory of Experimental Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, Utrecht, 3584 CX, Netherlands.
  • Sanghera DK Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
  • Sattar N Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
  • Schmidt R Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
  • Schulze MB Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Schunkert H Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, 80636, Germany.
  • Scott RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Shuldiner AR Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, 21201, USA.
  • Sim X Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
  • Small N Faculty of Health Studies, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK.
  • Smith JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Sotoodehnia N Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, 98101, USA.
  • Tai ES Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, 117549, Singapore.
  • Teumer A DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
  • Timpson NJ MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
  • Toniolo D San Raffaele Research Institute, Milano, Italy.
  • Tregouet DA INSERM UMR_S 1166, Sorbonne Universités, Paris, 75013, France.
  • Tuomi T Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  • Vollenweider P Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
  • Wang CA School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.
  • Weir DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
  • Whitfield JB QIMR Berghofer Institute of Medical Research, Brisbane, Australia.
  • Wijmenga C Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
  • Wong TY Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, 169856, Singapore.
  • Wright J Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Trust, Bradford, BD96RJ, UK.
  • Yang J Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Yu L Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Zemel BS Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Zonderman AB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, Maryland, 21224, USA.
  • Perola M Unit of Genomics and Biomarkers, National Institute for Health and Welfare, Helsinki, 00271, Finland.
  • Magnusson PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Uitterlinden AG Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
  • Kooner JS Department of Cardiology, Ealing Hospital, Middlesex, Middlesex, UB1 3HW, UK.
  • Chasman DI Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
  • Loos RJF The Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Franceschini N Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
  • Franke L Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands, Groningen, Groningen, 9700 RB, The Netherlands.
  • Haley CS MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, Scotland.
  • Hayward C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, Scotland.
  • Walters RG Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
  • Perry JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
  • Esko T Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
  • Helgason A deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Stefansson K deCODE genetics/Amgen Inc., Reykjavik 101, Iceland.
  • Joshi PK Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.
  • Kubo M Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
  • Wilson JF Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland. jim.wilson@ed.ac.uk.
Show more…
  • 2019-11-02
Published in:
  • Nature communications. - 2019
English In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/115625
Statistics

Document views: 131 File downloads:
  • Full-text: 0