The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules.
Journal article

The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules.

  • Sá J Department of Chemistry, Ångström Laboratory, Uppsala University, Sweden; Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland. Electronic address: jacinto.sa@kemi.uu.se.
  • Czapla-Masztafiak J Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Krakow, Poland; Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland.
  • Lipiec E Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Krakow, Poland.
  • Kayser Y Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland.
  • Kwiatek W Institute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Krakow, Poland.
  • Wood B Centre for Biospectroscopy, School of Chemistry, Monash University, 3800 Victoria, Australia.
  • Deacon GB School of Chemistry, Faculty of Science, Monash University, 3800 Victoria, Australia.
  • Berger G Laboratoire de Chimie Pharmaceutique Organique, Campus Plaine CP205/5, Université Libre de Bruxelles, Bd du Triomphe, B1050 Brussels, Belgium.
  • Dufrasne F Laboratoire de Chimie Pharmaceutique Organique, Campus Plaine CP205/5, Université Libre de Bruxelles, Bd du Triomphe, B1050 Brussels, Belgium.
  • Fernandes DL Department of Chemistry, Ångström Laboratory, Uppsala University, Sweden.
  • Szlachetko J Paul Scherrer Institute (PSI), 5232 Villigen, Switzerland; Institute of Physics, Jan Kochanowski University in Kielce, 25-406 Kielce, Poland. Electronic address: jakub.szlachetko@psi.ch.
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  • 2015-11-09
Published in:
  • Drug discovery today. Technologies. - 2015
English This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum in situ and in vivo. The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells.
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  • English
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closed
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https://sonar.ch/global/documents/115713
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