Journal article
Bovine Staphylococcus aureus: association of virulence genes, genotypes and clinical outcome.
- Fournier C Department of Clinical Veterinary Medicine, Vetsuisse-Faculty, University of Berne, 3001 Berne, Switzerland.
- Kuhnert P
- Frey J
- Miserez R
- Kirchhofer M
- Kaufmann T
- Steiner A
- Graber HU
- 2008-03-25
Published in:
- Research in veterinary science. - 2008
Animals
Bacterial Proteins
Cattle
Cattle Diseases
DNA Primers
DNA, Bacterial
Genotype
Polymerase Chain Reaction
RNA, Bacterial
Staphylococcal Infections
Staphylococcus aureus
Virulence
English
Based on our clinical experience on bovine mastitis, we hypothesized that subtypes of Staphylococcus aureus (S. aureus) exist which differ in their contagious and pathogenic properties. In order to investigate this hypothesis, we analyzed strains of S. aureus isolated from spontaneous intramammary infection (IMI) with their virulence gene patterns and genotypes obtained by PCR amplification of the 16S-23S rRNA intergenic spacer (RS-PCR). The genotypes were then associated with epidemiological and clinical data including 26 herds. The results demonstrated a high association between genotypes and virulence gene patterns as well as between epidemiological and pathogenic properties of S. aureus. In particular, genotype B was related to high contagiosity and increased pathogenicity whereas the other types (C, OG) were found with infection of single cows. Because of the high clinical relevance, our results indicate the need to subtype the IMI-associated strains of S. aureus in the future.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.rvsc.2008.01.010
- PMID 18358507
- Persistent URL
- https://sonar.ch/global/documents/115915
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