Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).
Journal article

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

  • Scheer M Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany. monika.scheer@olgahospital-stuttgart.de.
  • Blank B Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
  • Bauer S Sarcoma Center, West German Cancer Center, University of Duisburg-Essen, Essen, Germany.
  • Vokuhl C Kiel Paediatric Tumor Registry, Department of Paediatric Pathology, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Stegmaier S Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
  • Feuchtgruber S Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
  • Henssen A Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Sparber-Sauer M Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
  • Eggert A Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Handgretinger R Department of Pediatric Hematology and Oncology, University Children's Hospital, University Hospital Tuebingen, Tuebingen, Germany.
  • Pekrun A Department of Pediatric Hematology and Oncology, Hospital Bremen-Mitte, Bremen, Germany.
  • Rossig C Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.
  • Rutkowski S Pediatric Hematology and Oncology, University Hamburg-Eppendorf, Hamburg, Germany.
  • Schlegel PG University Children's Hospital, Pediatric Oncology, Hematology, Stem Cell Transplantation, University of Wuerzburg, Wuerzburg, Germany.
  • Schrappe M Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
  • Simon T Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.
  • Kazanowska B Department of Pediatric Oncology, University of Wroclaw, Wrocław, Poland.
  • Niggli F Department of Pediatric Oncology, University of Zuerich, Zuerich, Switzerland.
  • Ladenstein R St. Anna Kinderspital and St. Anna Kinderkrebsforschung e.V., Vienna, Austria.
  • Ljungman G Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  • Jahnukainen K New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Fuchs J Department of Pediatric Surgery and Urology, University Children's Hospital, Tuebingen, Germany.
  • Bielack SS Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
  • Koscielniak E Klinikum Stuttgart, Olgahospital, Pediatrics 5 (Oncology, Hematology, Immunology), Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
  • Klingebiel T Hospital for Children and Adolescents, Goethe-University, Frankfurt (Main), Germany.
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  • 2020-01-15
Published in:
  • Journal of cancer research and clinical oncology. - 2020
English BACKGROUND
Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown.


METHODS
SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test.


RESULTS
The study population included 432 SS patients. Disease characteristics differed according to age groups of children (0-12 years, n = 176), adolescents (13-16 years, n = 178), and young adults (17-21 years, n = 78). The proportion of invasive tumors (T2) was significantly higher in older patients: children 33%, adolescents 39% and young adults 54%, p = 0.009805. Similarly, the proportion of tumors > 10 cm was higher (13%, 21%, 31%; p = 0.005657) whereas conversely, the proportion of small tumors < 3 cm was lower in older patients (29%, 24%, 6%; p = 0.000104). The presence of metastases at first diagnosis was also highest in older patients (6%, 10%, 21%, p = 0.000963). Notably, the proportion of thigh tumors was higher in older patients (p = 0.04173), whereas the proportion of head-neck tumors was lower in older patients (p = 0.08896).


CONCLUSIONS
The rates of large, invasive tumors and the presence of metastases are significantly associated with older patient age. Localization to the thigh is more frequent in older patients.


DISCUSSION
The causes for these variations require further exploration.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/11595
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