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Common traits between the beige fat-inducing stimuli.
Journal article

Common traits between the beige fat-inducing stimuli.

  • Stojanović O University of Geneva, Faculty of Medicine, Department of Cell Physiology and Metabolism, Centre Médical Universitaire, 1211 Geneva, Switzerland; University of Geneva, Diabetes Centre, Faculty of Medicine, 1211 Geneva, Switzerland.
  • Kieser S University of Geneva, Faculty of Medicine, Department of Cell Physiology and Metabolism, Centre Médical Universitaire, 1211 Geneva, Switzerland; University of Geneva, Diabetes Centre, Faculty of Medicine, 1211 Geneva, Switzerland.
  • Trajkovski M University of Geneva, Faculty of Medicine, Department of Cell Physiology and Metabolism, Centre Médical Universitaire, 1211 Geneva, Switzerland; University of Geneva, Diabetes Centre, Faculty of Medicine, 1211 Geneva, Switzerland; Institute for Genetics and Genomics in Geneva, University of Geneva, 1211 Geneva, Switzerland. Electronic address: Mirko.Trajkovski@unige.ch.
  • 2018-07-15
Published in:
  • Current opinion in cell biology. - 2018
Adipose Tissue, Beige
Adipose Tissue, Brown
Energy Metabolism
Gastrointestinal Microbiome
Humans
Quantitative Trait, Heritable
English Adipose tissues play an essential role in regulating the metabolic homeostasis and can be found in almost all parts of the body. Excessive adiposity leads to obesity and can contribute to metabolic and other disorders. Adipocytes show remarkable plasticity in their function, which can be pushed toward energy storage, or energy expenditure-a `browning' of fat. Browning is controlled by the cellular milieu of the adipose tissue, with sympathetic innervation and by immune responses as key integrators of the signals that promote browning. Here, we describe the latest contributions to our understanding of how different metabolic stimuli can shape the adipocyte function. We especially focus on the role of the gut microbiota and the negative energy balance in regulating the browning.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/116477
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