Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.

• Ganesh SK Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sganesh@umich.edu.
• Chasman DI Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston MA, 02115, USA.
• Larson MG Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Department of Mathematics, Boston University, Boston, MA 02215, USA.
• Guo X Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
• Verwoert G Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Bis JC Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
• Gu X Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
• Smith AV Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
• Yang ML Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
• Zhang Y Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
• Ehret G Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns-Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.
• Rose LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
• Hwang SJ Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
• Papanicolau GJ Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
• Sijbrands EJ Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Rice K Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
• Eiriksdottir G Icelandic Heart Association, 201 Kopavogur, Iceland.
• Pihur V Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns-Hopkins University School of Medicine, Baltimore, MD 21205, USA.
• Ridker PM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston MA, 02115, USA.
• Vasan RS Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School for Medicine, Boston, MA 02118, USA.
• Newton-Cheh C Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.
• Raffel LJ Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Amin N Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
• Rotter JI Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
• Liu K Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD 20892, USA.
• Launer LJ Department of Cardiology, Peking University Third Hospital, Beijing 100191, China.
• Xu M Clinical Pharmacology and the Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
• Caulfield M Human Genetics Center, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
• Morrison AC Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 02892, USA.
• Johnson AD Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
• Vaidya D Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Dehghan A Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
• Li G Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
• Bouchard C Laboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD 20892, USA.
• Harris TB Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
• Zhang H Human Genetics Center, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
• Boerwinkle E Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA.
• Siscovick DS Department of Cardiology, Peking University Third Hospital, Beijing 100191, China.
• Gao W Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, 2593 the Hague, the Netherlands.
• Uitterlinden AG Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Rivadeneira F Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Hofman A Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
• Willer CJ Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Franco OH Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
• Huo Y Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
• Witteman JC Clinical Pharmacology and the Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
• Munroe PB Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
• Gudnason V Department of Medicine, Columbia University, New York, NY 10032, USA.
• Palmas W Department of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, 2593 the Hague, the Netherlands; Centre for Medical Systems Biology, Netherlands Genomics Initiative, 2593 the Hague, the Netherlands.
• van Duijn C Research Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
• Fornage M Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA; Boston University School of Medicine, Boston, MA 02118, USA.
• Levy D Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.
• Psaty BM Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns-Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aravinda@jhmi.edu.
• Chakravarti A

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Blood Pressure

Genome-Wide Association Study

Humans

Longitudinal Studies

Phenotype

Polymorphism, Single Nucleotide

Quantitative Trait Loci