Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.

• Hou L Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
• Heilbronner U Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
• Degenhardt F Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
• Adli M Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany; Fliedner Klinik Berlin, Center for Psychiatry, Psychotherapy and Psychosomatic Medicine, Berlin, Germany.
• Akiyama K Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.
• Akula N Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
• Ardau R Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
• Arias B Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.
• Backlund L Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
• Banzato CEM Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.
• Benabarre A Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
• Bengesser S Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.
• Bhattacharjee AK Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
• Biernacka JM Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
• Birner A Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.
• Brichant-Petitjean C INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.
• Bui ET Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
• Cervantes P The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.
• Chen GB The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.
• Chen HC Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
• Chillotti C Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
• Cichon S Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
• Clark SR Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
• Colom F Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
• Cousins DA Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
• Cruceanu C Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
• Czerski PM Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
• Dantas CR Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.
• Dayer A Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.
• Étain B Inserm U955, Psychiatrie Translationnelle, Créteil, France.
• Falkai P Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
• Forstner AJ Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
• Frisén L Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Child and Adolescent Psychiatry Research Center, Stockholm, Sweden.
• Fullerton JM Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
• Gard S Pôle de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France.
• Garnham JS Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.
• Goes FS Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
• Grof P Mood Disorders Center of Ottawa, Ottawa, ON, Canada.
• Gruber O Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
• Hashimoto R Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
• Hauser J Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
• Herms S Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
• Hoffmann P Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
• Hofmann A Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
• Jamain S Inserm U955, Psychiatrie Translationnelle, Créteil, France.
• Jiménez E Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
• Kahn JP Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Laxou-Université de Lorraine, Nancy, France.
• Kassem L Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
• Kittel-Schneider S Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
• Kliwicki S Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
• König B Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
• Kusumi I Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
• Lackner N Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.
• Laje G Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
• Landén M Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• Lavebratt C Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
• Leboyer M Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.
• Leckband SG Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.
• Jaramillo CAL Department of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia.
• MacQueen G Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
• Manchia M Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
• Martinsson L Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
• Mattheisen M Department of Biomedicine, Aarhus University, Aarhus, Denmark.
• McCarthy MJ Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.
• McElroy SL Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, OH, USA.
• Mitjans M Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.
• Mondimore FM Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
• Monteleone P Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy; Department of Psychiatry, University of Naples SUN, Naples, Italy.
• Nievergelt CM Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
• Nöthen MM Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
• Ösby U Department of Neurobiology, Care sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
• Ozaki N Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
• Perlis RH Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• Pfennig A Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
• Reich-Erkelenz D Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.
• Rouleau GA Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
• Schofield PR Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
• Schubert KO Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
• Schweizer BW Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
• Seemüller F Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
• Severino G Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
• Shekhtman T Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
• Shilling PD Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
• Shimoda K Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.
• Simhandl C Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria.
• Slaney CM Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.
• Smoller JW Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• Squassina A Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
• Stamm T Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
• Stopkova P National Institute of Mental Health, Klecany, Czech Republic.
• Tighe SK Department of Psychiatry, University of Iowa, Iowa City, IA, USA; University of Iowa Carver College of Medicine and University of Iowa College of Public Health, VA Quality Scholars Program, Iowa City VA Hospital, Iowa City, IA, USA.
• Tortorella A Department of Psychiatry, University of Naples SUN, Naples, Italy.
• Turecki G Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
• Volkert J Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
• Witt S Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
• Wright A School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
• Young LT Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
• Zandi PP Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
• Potash JB Department of Psychiatry, University of Iowa, Iowa City, IA, USA.
• DePaulo JR Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
• Bauer M Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
• Reininghaus EZ Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.
• Novák T National Institute of Mental Health, Klecany, Czech Republic.
• Aubry JM Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.
• Maj M Department of Psychiatry, University of Naples SUN, Naples, Italy.
• Baune BT Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
• Mitchell PB School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
• Vieta E Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
• Frye MA Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
• Rybakowski JK Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
• Kuo PH Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
• Kato T Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.
• Grigoroiu-Serbanescu M Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania.
• Reif A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
• Del Zompo M Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
• Bellivier F INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.
• Schalling M Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
• Wray NR The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.
• Kelsoe JR Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
• Alda M Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada; National Institute of Mental Health, Klecany, Czech Republic.
• Rietschel M Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
• McMahon FJ Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA. Electronic address: mcmahonf@mail.nih.gov.
• Schulze TG Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA; Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: thomas.schulze@med.uni-muenchen.de.

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Bipolar Disorder

Female

Genetic Variation

Genome-Wide Association Study

Genotype

Glial Cell Line-Derived Neurotrophic Factor Receptors

Humans

Lithium Compounds

Male

Middle Aged

Phenotype

Polymorphism, Single Nucleotide

Prospective Studies

Treatment Outcome