Journal article
Pediatric pulmonary hypertension.
- Ivy DD Pediatric Cardiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado. Electronic address: dunbar.ivy@childrenscolorado.org.
- Abman SH Pediatric Pulmonary Medicine, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
- Barst RJ Columbia University, College of Physicians and Surgeons, New York, New York.
- Berger RM Centre for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- Bonnet D Centre de Référence Malformations Cardiaques Congénitales Complexes, Necker Hospital for Sick Children, Assistance Publique des Hôpitaux de Paris, Pediatric Cardiology, University Paris Descartes, Paris, France.
- Fleming TR Department of Biostatistics, University of Washington, Seattle, Washington.
- Haworth SG Great Ormond Street Hospital, London, United Kingdom.
- Raj JU Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.
- Rosenzweig EB Columbia University, College of Physicians and Surgeons, New York, New York.
- Schulze Neick I Great Ormond Street Hospital, London, United Kingdom.
- Steinhorn RH Department of Pediatrics, University of California Davis Children's Hospital, Davis, California.
- Beghetti M Pediatric Cardiology Unit, University Hospital, Geneva, Switzerland.
- 2013-12-21
Published in:
- Journal of the American College of Cardiology. - 2013
APAH-CHD
AVT
CHD
HPAH
IPAH
PAPm
PH
PHVD
PPHN
PVR
SVR
acute vasodilator testing
congenital heart disease
hereditary pulmonary arterial hypertension
idiopathic pulmonary arterial hypertension
mean pulmonary artery pressure
pediatrics
persistent pulmonary hypertension of the newborn
pulmonary arterial hypertension associated with congenital heart disease
pulmonary hypertension
pulmonary hypertensive vascular disease
pulmonary vascular resistance
systemic vascular resistance
Age Factors
Animals
Child
Humans
Hypertension, Pulmonary
Incidence
Infant
Infant, Newborn
Netherlands
English
Pulmonary hypertension (PH) is a rare disease in newborns, infants, and children that is associated with significant morbidity and mortality. In the majority of pediatric patients, PH is idiopathic or associated with congenital heart disease and rarely is associated with other conditions such as connective tissue or thromboembolic disease. Incidence data from the Netherlands has revealed an annual incidence and point prevalence of 0.7 and 4.4 for idiopathic pulmonary arterial hypertension and 2.2 and 15.6 for pulmonary arterial hypertension, respectively, associated with congenital heart disease (CHD) cases per million children. The updated Nice classification for PH has been enhanced to include a greater depth of CHD and emphasizes persistent PH of the newborn and developmental lung diseases, such as bronchopulmonary dysplasia and congenital diaphragmatic hernia. The management of pediatric PH remains challenging because treatment decisions continue to depend largely on results from evidence-based adult studies and the clinical experience of pediatric experts.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.jacc.2013.10.028
- PMID 24355636
- Persistent URL
- https://sonar.ch/global/documents/118219
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