Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

• Karlsson Linnér R Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands. r.karlssonlinner@vu.nl.
• Biroli P Department of Economics, University of Zurich, Zurich, Switzerland.
• Kong E Department of Economics, Harvard University, Cambridge, MA, USA.
• Meddens SFW Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Wedow R Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Fontana MA Center for the Advancement of Value in Musculoskeletal Care, Hospital for Special Surgery, New York, NY, USA.
• Lebreton M Amsterdam School of Economics, University of Amsterdam, Amsterdam, the Netherlands.
• Tino SP Department of Economics, University of Toronto, Toronto, Ontario, Canada.
• Abdellaoui A Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
• Hammerschlag AR Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Nivard MG Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
• Okbay A Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Rietveld CA Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
• Timshel PN Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
• Trzaskowski M Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
• Vlaming R Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Zünd CL Department of Economics, University of Zurich, Zurich, Switzerland.
• Bao Y Institute for Social and Economic Research, University of Essex, Colchester, UK.
• Buzdugan L Seminar for Statistics, Department of Mathematics, ETH Zurich, Zurich, Switzerland.
• Caplin AH Stuyvesant High School, New York, NY, USA.
• Chen CY Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Eibich P Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• Fontanillas P Research, 23andMe, Inc., Mountain View, CA, USA.
• Gonzalez JR Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
• Joshi PK Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
• Karhunen V Center for Life Course Health Research, University of Oulu, Oulu, Finland.
• Kleinman A Research, 23andMe, Inc., Mountain View, CA, USA.
• Levin RZ Department of Economics, University of California San Diego, La Jolla, CA, USA.
• Lill CM Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
• Meddens GA Team Loyalty BV, Hoofddorp, the Netherlands.
• Muntané G Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
• Sanchez-Roige S Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
• Rooij FJV Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
• Taskesen E Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Wu Y Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
• Zhang F Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
• Auton A Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
• Boardman JD Department of Economics, University of Konstanz, Konstanz, Germany.
• Clark DW Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
• Conlin A Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• Dolan CC Unit of Psychiatry Research, University of Fribourg, Fribourg, Switzerland.
• Fischbacher U Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
• Groenen PJF Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
• Harris KM Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
• Hasler G Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• Hofman A Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
• Ikram MA SURFsara, Amsterdam, the Netherlands.
• Jain S Peter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
• Karlsson R Center for Life Course Health Research, University of Oulu, Oulu, Finland.
• Kessler RC Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
• Kooyman M Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
• MacKillop J Department of Economics, University of Munich, Munich, Germany.
• Männikkö M Institute for Social and Economic Research, University of Essex, Colchester, UK.
• Morcillo-Suarez C Department of Economics, University of Cologne, Cologne, Germany.
• McQueen MB Erasmus University Rotterdam Institute for Behavior and Biology, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
• Schmidt KM Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, the Netherlands.
• Smart MC UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK.
• Sutter M Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
• Thurik AR Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
• Uitterlinden AG Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
• White J Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
• Wit H Estonian Genome Center, University of Tartu, Tartu, Estonia.
• Yang J Department of Economics, University of Zurich, Zurich, Switzerland.
• Bertram L Research, 23andMe, Inc., Mountain View, CA, USA.
• Boomsma DI Department of Economics, Stockholm School of Economics, Stockholm, Sweden.
• Esko T Institute for Social and Economic Research, University of Essex, Colchester, UK.
• Fehr E Department of Economics, Harvard University, Cambridge, MA, USA.
• Hinds DA Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• Johannesson M Center for Translational Bioethics and Health Care Policy, Geisinger Health System, Danville, PA, USA.
• Kumari M Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.
• Laibson D Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
• Magnusson PKE Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
• Meyer MN Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Navarro A Department of Economics, Johannes Gutenberg University, Mainz, Germany.
• Palmer AA Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
• Pers TH Department of Economics and Finance, Oulu Business School, University of Oulu, Oulu, Finland.
• Posthuma D Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
• Schunk D Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
• Stein MB Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Svento R Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• Tiemeier H Socio-Economic Panel Study, DIW Berlin, Berlin, Germany.
• Timmers PRHJ Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
• Turley P Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
• Ursano RJ Department of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
• Wagner GG Department of Economics, New York University, New York, NY, USA.
• Wilson JF Behavioral and Health Genomics Center, Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
• Gratten J Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands.
• Lee JJ Department of Economics, University of Toronto, Toronto, Ontario, Canada. jonathan.pierre.beauchamp@gmail.com.
• Cesarini D
• Benjamin DJ
• Koellinger PD
• Beauchamp JP

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Behavior

Case-Control Studies

Female

Genetic Loci

Genetic Predisposition to Disease

Genetics, Behavioral

Genome-Wide Association Study

Genotype

Humans

Male

Polymorphism, Single Nucleotide