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The Aurora kinase inhibitors in cancer research and therapy.
Journal article

The Aurora kinase inhibitors in cancer research and therapy.

  • Cicenas J CALIPHO Group, Swiss Institute of Bioinformatics, CMU-1, rue Michel Servet, 1211, Geneva 4, Switzerland. j.cicenas@mapkinases.eu.
  • 2016-03-03
Published in:
  • Journal of cancer research and clinical oncology. - 2016
Aurora kinases
Cancer
Cell cycle
Protein kinases
Small-molecule inhibitors
Animals
Aurora Kinases
Biomedical Research
Humans
Models, Molecular
Neoplasms
Protein Kinase Inhibitors
English Compounds that affect enzymatic function of kinases are valuable for the understanding of the complex biochemical processes in cells. Aurora kinases (AURKs) play a key role in the control of the mitosis. These kinases are frequently deregulated in different human cancers: overexpression, amplifications, translocations and deletions were reported in many cancer cell lines as well as patient tissues. These findings steered a rigorous hunt for small-molecule AURK inhibitors not only for research purposes as well as for therapeutic uses. In this review, we describe a number of AURK inhibitors and their use in cancer research and/or therapy. We hope to assist researchers and clinicians in deciding which inhibitor is most appropriate for their specific purpose. The review will also provide a broad overview of the clinical studies performed with some of these inhibitors (if such studies have been performed).
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/119934
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