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Glioblastomas on the move.
Journal article

Glioblastomas on the move.

  • Merlo A Department of Clinical-Biological Sciences, University Hospitals, University of Basel, Switzerland. amerlo@uhbs.ch
  • Bettler B
  • 2004-04-22
Published in:
  • Science's STKE : signal transduction knowledge environment. - 2004
Glioblastoma
Humans
Neoplasm Invasiveness
English The mechanism by which the tumor suppressor PTEN slows tumor cell migration is not well characterized. A recent study by Raftopoulou et al. shows that a lack of PTEN protein phosphatase activity accelerates the migration of glioblastoma cells. The protein phosphatase activity of PTEN is directly or indirectly responsible for dephosphorylating a PTEN residue, threonine-383, which is necessary for slowing cell migration. These findings have implications for the design of new therapies against glioblastomas and other highly invasive cancers.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/12084
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