Glioblastomas on the move.

Merlo A; Bettler B

doi:10.1126/stke.2292004pe18

Back

Journal article

Glioblastomas on the move.

Merlo A Department of Clinical-Biological Sciences, University Hospitals, University of Basel, Switzerland. amerlo@uhbs.ch
Bettler B

2004-04-22

Published in:

Science's STKE : signal transduction knowledge environment. - 2004

English The mechanism by which the tumor suppressor PTEN slows tumor cell migration is not well characterized. A recent study by Raftopoulou et al. shows that a lack of PTEN protein phosphatase activity accelerates the migration of glioblastoma cells. The protein phosphatase activity of PTEN is directly or indirectly responsible for dephosphorylating a PTEN residue, threonine-383, which is necessary for slowing cell migration. These findings have implications for the design of new therapies against glioblastomas and other highly invasive cancers.

Language