Effects of N-glycosylation of the human cation channel TRPA1 on agonist-sensitivity
- Egan, Timothy J. Numab AG, 8820-Wädenswil, Switzerland
- Acuña, Mario A. Institute of Pharmacology & Toxicology, University of Zurich (UZH), 8057-Zurich, Switzerland
- Zenobi-Wong, Marcy Cartilage Engineering & Regeneration Lab, the Department of Health, Science & Technology, The Swiss Federal Institute of Technology (ETH), 8049-Zurich, Switzerland
- Zeilhofer, Hanns Ulrich Institute of Pharmacology & Toxicology, University of Zurich (UZH), 8057-Zurich, Switzerland
- Urech, David Numab AG, 8820-Wädenswil, Switzerland
- 2016-10-6
Published in:
- Bioscience Reports. - Portland Press Ltd.. - 2016, vol. 36, no. 5
English
Our experiments confirm N-glycosylation of the human cation channel TRPA1 and suggest a role of the N-glycan at position Asn747 in determining channel sensitivity to various agonists. Further, the activity-modulating effects of TRPA1 N-glycans are evidently influenced by temperature.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1042/bsr20160149
- ISSN 0144-8463
- Persistent URL
- https://sonar.ch/global/documents/121701
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