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Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation.
Journal article

Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation.

  • Meyer U Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland. Electronic address: urs.meyer@vetpharm.uzh.ch.
  • 2019-09-09
Published in:
  • Trends in neurosciences. - 2019
animal models
infection
inflammation
maternal immune activation
neurodevelopment
poly(I:C)
Animals
Female
Humans
Immune System
Neurodevelopmental Disorders
Pregnancy
Pregnancy Complications, Infectious
Prenatal Exposure Delayed Effects
English Maternal immune activation (MIA), be it triggered by infectious or noninfectious stimuli, is implicated in various psychiatric and neurological disorders with developmental etiologies. Its consequences on the offspring's mental health are heterogeneous and influenced by a number of factors shaping the specificity and/or severity of pathological outcomes. There is also a substantial degree of resilience to MIA, which determines the extent to which offspring are protected from developing neurodevelopmental sequelae. This review provides a synopsis of the plausible sources that account for the heterogeneous outcomes of MIA and discusses key factors that are critical for establishing neurodevelopmental resilience and susceptibility to this early-life adversity.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/122210
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