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Peroxynitrous acid--where is the hydroxyl radical?
Journal article

Peroxynitrous acid--where is the hydroxyl radical?

  • 2004-01-09
Published in:
  • IUBMB life. - 2003
Dehydroascorbic Acid
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Hydroxyl Radical
Kinetics
Models, Chemical
Nitrates
Nitrites
Peroxynitrous Acid
Pressure
Time Factors
English Peroxynitrite is an inorganic toxin of physiological interest, formed from the diffusion-controlled reaction of superoxide and nitrogen monoxide with a rate constant of (1.6 +/- 0.3) x 10(10) M(-1) s(-1). On the basis of three experiments we conclude that homolysis of the O-O bond in peroxynitrous acid is unlikely: (1) the yield of nitrite from the decomposition of peroxynitrite shows a dependence on the peroxynitrite concentration and is lower than expected for homolysis; (2) the yield of [15N]nitrate from the reaction of [15N]nitrite with peroxynitrous acid predicted by homolysis does not correspond to that found experimentally, and (3) the reaction of peroxynitrous acid with monohydroascorbate does not yield ascorbyl radicals. Activation volumes determined from high-pressure kinetic studies are inconclusive.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/122514
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