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Tissue microarrays in cancer diagnosis.
Journal article

Tissue microarrays in cancer diagnosis.

  • Simon R Institute of Pathology, Division of Molecular Pathology, University of Basel, Switzerland. Ronald.Simon@unibas.ch
  • Mirlacher M
  • Sauter G
  • 2003-07-25
Published in:
  • Expert review of molecular diagnostics. - 2003
Histocytological Preparation Techniques
Humans
Molecular Diagnostic Techniques
Neoplasms
Oligonucleotide Array Sequence Analysis
Prognosis
Protein Array Analysis
Survival Rate
English New molecular techniques such as cDNA, protein or antibody arrays allow for high-throughput identification of thousands of potentially disease-related markers on the genome, transcriptome and proteome level. Major disadvantages of such studies are the enormous costs and the need for unfixed tissues, disallowing comprehensive large-scale studies. Consequently, validation studies including large sets of clinically well-defined tissue samples are now necessary to identify those genes or proteins with true impact on the course of disease which will eventually lead to therapeutic applications. Tissue microarray technology overcomes the bottleneck of traditional tissue analysis and allows it to catch up with the rapid advances in lead discovery. Current applications and the future potential of tissue microarray technology in cancer research and diagnosis are discussed.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/12256
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